High self-esteem, hardiness and affective stability are associated with higher basal pituitary-adrenal hormone levels.


:Whereas much is known about the function of the hypothalamic-pituitary-adrenal (HPA) axis during environmental stress and in psychiatric disorders, little is known about the relation of individual differences in basal HPA-functioning to individual differences in healthy psychological functioning. In the present study, we recruited 37 healthy young men and examined the relations of hardiness, self-esteem and hypomanic personality--dispositions that moderate the effects of psychosocial stress on depressive reactions and health--to circulating levels of cortisol and beta-endorphin at rest. High self-esteem, hardiness and affective stability were associated with higher plasma cortisol levels and less psychological distress. Additionally, affective stability was associated with higher levels of beta-endorphin. The present findings suggest that individual differences in basal HPA-function are associated with individual differences in psychological functioning following stress.




Zorrilla EP,DeRubeis RJ,Redei E




Has Abstract


1995-01-01 00:00:00














  • Omega-3 and omega-6 fatty acid levels in depressive and anxiety disorders.

    abstract:BACKGROUND:Blood levels of polyunsaturated fatty acids (PUFAs) have been associated to current depression. However, it is unclear whether this association extends to remitted depression and to anxiety disorders. This study examined the relationship of PUFAs with the presence and clinical characteristics of depressive a...


    pub_type: 杂志文章


    authors: Thesing CS,Bot M,Milaneschi Y,Giltay EJ,Penninx BWJH

    更新日期:2018-01-01 00:00:00

  • Activation of the kynurenine pathway is associated with striatal volume in major depressive disorder.

    abstract::Inflammation, which may be present in a subgroup of individuals with major depressive disorder (MDD), activates the kynurenine metabolic pathway to produce kynurenine metabolites kynurenic acid (KynA) and quinolinic acid (QA). We have previously reported an association between the ratio of KynA to QA and hippocampal v...


    pub_type: 杂志文章


    authors: Savitz J,Dantzer R,Meier TB,Wurfel BE,Victor TA,McIntosh SA,Ford BN,Morris HM,Bodurka J,Teague TK,Drevets WC

    更新日期:2015-12-01 00:00:00

  • Early adverse experience alters dendritic spine density and gene expression in prefrontal cortex and hippocampus in lambs.

    abstract::In the laboratory, prenatal stress produces alterations in the structure and function of corticolimbic neurons. Here we report changes in gene expression and corticolimbic dendritic spine morphology in the offspring of pregnant ewes subjected to aversive interactions with human handlers during the last five weeks of p...


    pub_type: 杂志文章


    authors: Coulon M,Wellman CL,Marjara IS,Janczak AM,Zanella AJ

    更新日期:2013-07-01 00:00:00

  • Plasma corticosterone, dexamethasone (DEX) suppression and DEX/CRH tests in a rat model of genetic vulnerability to depression.

    abstract::The hypothalamo-pituitary-adrenal (HPA) axis is hyperactive in major depressive disorder (MDD), and baseline cortisol levels are usually elevated in MDD patients, with alterations of the circadian hormone secretion pattern. The dexamethasone (DEX) suppression test (DST) has been extensively applied to diagnose a dysre...


    pub_type: 杂志文章


    authors: Steimer T,Python A,Schulz PE,Aubry JM

    更新日期:2007-06-01 00:00:00

  • Methylation of HPA axis related genes in men with hypersexual disorder.

    abstract::Hypersexual Disorder (HD) defined as non-paraphilic sexual desire disorder with components of compulsivity, impulsivity and behavioral addiction, and proposed as a diagnosis in the DSM 5, shares some overlapping features with substance use disorder including common neurotransmitter systems and dysregulated hypothalami...


    pub_type: 杂志文章


    authors: Jokinen J,Boström AE,Chatzittofis A,Ciuculete DM,Öberg KG,Flanagan JN,Arver S,Schiöth HB

    更新日期:2017-06-01 00:00:00

  • The cortisol awakening response in relation to objective and subjective measures of waking in the morning.

    abstract::Studies of the salivary cortisol awakening response (CAR) may be confounded by delays between waking in the morning and obtaining the 'waking' salivary sample. We used wrist actigraphy to provide objective information about waking time, and studied the influence of delays in taking the waking sample on the CAR. Eighty...


    pub_type: 杂志文章,多中心研究


    authors: Dockray S,Bhattacharyya MR,Molloy GJ,Steptoe A

    更新日期:2008-01-01 00:00:00

  • Diurnal profiles of salivary cortisol and alpha-amylase change across the adult lifespan: evidence from repeated daily life assessments.

    abstract::Salivary cortisol and alpha-amylase are known to have distinctive diurnal profiles. However, little is known about systematic changes in these biomarkers across the adult lifespan. In a study of 185 participants (aged 20-81 years), time-stamped salivary cortisol and alpha-amylase were collected 7 times/day over 10 day...


    pub_type: 杂志文章


    authors: Nater UM,Hoppmann CA,Scott SB

    更新日期:2013-12-01 00:00:00

  • A human chemosignal modulates frontolimbic activity and connectivity in response to emotional stimuli.

    abstract::Evidence suggests the putative human pheromone Δ4,16-androstadien-3-one (androstadienone), a natural component of human sweat, increases attention to emotional information when passively inhaled, even in minute amounts. However, the neural mechanisms underlying androstadienone's impact on the perception of emotional s...


    pub_type: 杂志文章


    authors: Hummer TA,Phan KL,Kern DW,McClintock MK

    更新日期:2017-01-01 00:00:00

  • Hippocampal insulin resistance links maternal obesity with impaired neuronal plasticity in adult offspring.

    abstract:OBJECTIVE:Maternal obesity and a disturbed metabolic environment during pregnancy and lactation have been shown to result in many long-term health consequences for the offspring. Among them, impairments in neurocognitive development and performance belong to the most dreaded ones. So far, very few mechanistic approache...


    pub_type: 杂志文章


    authors: Schmitz L,Kuglin R,Bae-Gartz I,Janoschek R,Appel S,Mesaros A,Jakovcevski I,Vohlen C,Handwerk M,Ensenauer R,Dötsch J,Hucklenbruch-Rother E

    更新日期:2018-03-01 00:00:00

  • Postnatal behavioral and inflammatory alterations in female pups prenatally exposed to valproic acid.

    abstract::In Autism Spectrum Disorders (ASD), a bias to a higher incidence in boys than in girls has been reported. With the aim to identify biological mechanisms acting in female animals that could underlie this bias, we used an extensively validated mouse model of ASD: the prenatal exposure to valproic acid (VPA). We found po...


    pub_type: 杂志文章


    authors: Kazlauskas N,Campolongo M,Lucchina L,Zappala C,Depino AM

    更新日期:2016-10-01 00:00:00

  • Psychosocial factors, respiratory viruses and exacerbation of asthma.

    abstract::The aim of this research was study the role of psychosocial factors in exacerbations of asthma in adults induced by upper respiratory tract infections (URTIs). It involved a longitudinal study (one year) of 92 adults with asthma. The volunteers were 27 men and 65 women 19-46 years of age with a mean duration of wheeze...


    pub_type: 杂志文章


    authors: Smith A,Nicholson K

    更新日期:2001-05-01 00:00:00

  • Latent trait cortisol (LTC) during pregnancy: Composition, continuity, change, and concomitants.

    abstract::Individual differences in the activity of the hypothalamic pituitary adrenal (HPA) axis are often operationalized using summary measures of cortisol that are taken to represent stable individual differences. Here we extend our understanding of a novel latent variable approach to latent trait cortisol (LTC) as a measur...


    pub_type: 杂志文章


    authors: Giesbrecht GF,Bryce CI,Letourneau N,Granger DA,APrON study Team.

    更新日期:2015-12-01 00:00:00

  • Testosterone shifts the balance between sensitivity for punishment and reward in healthy young women.

    abstract::Animal research has demonstrated reductions in punishment sensitivity and enhanced reward dependency after testosterone administration. In humans, elevated levels of testosterone have been associated with violent and antisocial behavior. Interestingly, extreme forms of violent and antisocial behavior can be observed i...


    pub_type: 临床试验,杂志文章


    authors: van Honk J,Schutter DJ,Hermans EJ,Putman P,Tuiten A,Koppeschaar H

    更新日期:2004-08-01 00:00:00

  • Diurnal salivary cortisol and nativity/duration of residence in Latinos: The Multi-Ethnic Study of Atherosclerosis.

    abstract::Latino immigrants have lower prevalence of depression, obesity and cardiovascular disease than US-born Latinos when they are recently arrived in the US, but this health advantage erodes with increasing duration of US residence. Cumulative exposure to psychosocial stress and its physiological sequelae may mediate the r...


    pub_type: 杂志文章


    authors: Novak NL,Wang X,Clarke PJ,Hajat A,Needham BL,Sánchez BN,Rodriguez CJ,Seeman TE,Castro-Diehl C,Golden SH,Diez Roux AV

    更新日期:2017-11-01 00:00:00

  • Histories of abuse predict stronger within-person covariation of ovarian steroids and mood symptoms in women with menstrually related mood disorder.

    abstract:OBJECTIVE:Individual differences in sensitivity to cyclical changes in ovarian steroids estradiol (E2) and progesterone (P4) have been implicated in the pathophysiology of menstrually related mood disorder (MRMD). However, no prospective studies have investigated psychosocial risk factors for sensitivity to hormone eff...


    pub_type: 杂志文章


    authors: Eisenlohr-Moul TA,Rubinow DR,Schiller CE,Johnson JL,Leserman J,Girdler SS

    更新日期:2016-05-01 00:00:00

  • Psychological stress and cortisol during pregnancy: An ecological momentary assessment (EMA)-Based within- and between-person analysis.

    abstract:BACKGROUND:Although the linkage between psychological stress and cortisol is believed to mediate the association of stress with health outcomes, several studies have been unable to demonstrate this association. We suggest this inability may be a consequence of limitations in the measurement approach and/or reliance on ...


    pub_type: 杂志文章


    authors: Lazarides C,Ward EB,Buss C,Chen WP,Voelkle MC,Gillen DL,Wadhwa PD,Entringer S

    更新日期:2020-11-01 00:00:00

  • Exogenous testosterone increases status-seeking motivation in men with unstable low social status.

    abstract::Testosterone is associated with status-seeking behaviors such as competition, which may depend on whether one wins or loses status, but also on the stability of one's status. We examined (1) to what extent testosterone administration affects competition behavior in repeated social contests in men with high or low rank...


    pub_type: 杂志文章


    authors: Losecaat Vermeer AB,Krol I,Gausterer C,Wagner B,Eisenegger C,Lamm C

    更新日期:2020-03-01 00:00:00

  • Cortisol increase in empathic stress is modulated by emotional closeness and observation modality.

    abstract::Stress disorders are among the most commonly occurring of all mental disorders. In this context, the question arises whether the stress inevitably unfolding around us has the potential to "contaminate" and compromise us. In the current multi-center study, we investigate the existence of such empathic stress (defined a...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Engert V,Plessow F,Miller R,Kirschbaum C,Singer T

    更新日期:2014-07-01 00:00:00

  • Taiji practice attenuates psychobiological stress reactivity--a randomized controlled trial in healthy subjects.

    abstract:BACKGROUND:Stress reducing effects of Taiji, a mindful and gentle form of body movement, have been reported in previous studies, but standardized and controlled experimental studies are scarce. The present study investigates the effect of regular Taiji practice on psychobiological stress response in healthy men and wom...


    pub_type: 杂志文章,随机对照试验


    authors: Nedeljkovic M,Ausfeld-Hafter B,Streitberger K,Seiler R,Wirtz PH

    更新日期:2012-08-01 00:00:00

  • Oxytocin improves mentalizing - pronounced effects for individuals with attenuated ability to empathize.

    abstract::The ability to predict the behavior of others based on their mental states is crucial for social functioning. Previous studies have provided evidence for the role of Oxytocin (OXT) in enhancing the ability to mentalize. It has also been demonstrated that the effect of OXT seems to strongly depend on socio-cognitive sk...


    pub_type: 杂志文章


    authors: Feeser M,Fan Y,Weigand A,Hahn A,Gärtner M,Böker H,Grimm S,Bajbouj M

    更新日期:2015-03-01 00:00:00

  • Pain exposure associates with telomere length erosion in very preterm infants.

    abstract::Very preterm (VPT) infants (gestational age < 32 weeks) require long-lasting hospitalization in the Neonatal Intensive Care Unit (NICU), even in absence of severe morbidities. During NICU stay, life-saving interventions occur and include invasive and painful skin-breaking procedures (NICU-related stress), which consti...


    pub_type: 杂志文章


    authors: Provenzi L,Giorda R,Fumagalli M,Pozzoli U,Morandi F,Scotto di Minico G,Mosca F,Borgatti R,Montirosso R

    更新日期:2018-03-01 00:00:00

  • Cultures under stress: A cross-national meta-analysis of cortisol responses to the Trier Social Stress Test and their association with anxiety-related value orientations and internalizing mental disorders.

    abstract::Acute cortisol changes are physiological indicators (i.e., biomarkers) of psychosocial stress that have been repeatedly assessed using standardized laboratory protocols like the Trier Social Stress Test (TSST). Despite this methodological standardization, however, cortisol stress responses vary considerably across dif...


    pub_type: 杂志文章,meta分析,评审


    authors: Miller R,Kirschbaum C

    更新日期:2019-07-01 00:00:00

  • Parental adiposity and cortisol awakening responses in young men and women.

    abstract::A heightened cortisol awakening response (CAR) is associated with adiposity in middle-aged men, but the causal significance of this effect is not known. We hypothesised that if disturbance in cortisol secretion is involved in the development of overweight and obesity, then it might be present in normal weight adults a...


    pub_type: 杂志文章


    authors: Steptoe A,Wright CE,O'Donnell K,Brydon L,Wardle J

    更新日期:2006-10-01 00:00:00

  • Processing of food stimuli is selectively enhanced during insulin-induced hypoglycemia in healthy men.

    abstract::Recently it has been reported that during insulin-induced hypoglycemia selective attention is directed to food stimuli suggesting an adaptive cognitive strategy to escape from this potentially dangerous metabolic state. Here, we tested this hypothesis using a short-term memory task. We also aimed to define a hypoglyce...


    pub_type: 临床试验,杂志文章


    authors: Schultes B,Peters A,Kern W,Gais S,Oltmanns KM,Fehm HL,Born J

    更新日期:2005-06-01 00:00:00

  • Comparison of growth hormone stimulation induced by desimipramine, diazepam and metaclazepam in man.

    abstract::A comparison of the effect on growth hormone (GH) stimulation in men (n = 6) of desimipramine (DMI), a tricyclic antidepressant, and of the benzodiazepine derivatives diazepam and metaclazepam with that of a placebo, showed that only DMI caused a significant (p less than 0.01) GH stimulation. After DMI, all six subjec...


    pub_type: 临床试验,杂志文章


    authors: Laakmann G,Treusch J,Schmauss M,Schmitt E,Treusch U

    更新日期:1982-01-01 00:00:00

  • Lasting Impact of Chronic Adolescent Stress and Glucocorticoid Receptor Selective Modulation in Male and Female Rats.

    abstract::Adolescent animals are vulnerable to the effects of stress on brain development. We hypothesized that long-term effects of adolescent chronic stress are mediated by glucocorticoid receptor (GR) signaling. We used a specific GR modulator (CORT108297) to pharmacologically disrupt GR signaling in adolescent rats during e...


    pub_type: 杂志文章


    authors: Cotella EM,Morano RL,Wulsin AC,Martelle SM,Lemen P,Fitzgerald M,Packard BA,Moloney RD,Herman JP

    更新日期:2020-02-01 00:00:00

  • Functional alterations of the nigrostriatal dopamine system in estrogen receptor-alpha knockout (ERKO) mice.

    abstract::Estrogen represents an important factor for the development and function of the nigrostriatal dopamine system. Estrogen also controls sex-specific differentiation and activity of the nigrostriatal dopaminergic system. We used an estrogen receptor-alpha knockout (-/-) model (ERKO) to study the influence of this particu...


    pub_type: 杂志文章


    authors: Küppers E,Krust A,Chambon P,Beyer C

    更新日期:2008-07-01 00:00:00

  • No major month to month variation in free testosterone levels in aging males. Minor impact on the biological diagnosis of 'andropause'.

    abstract:BACKGROUND:The measurement of bioavailable testosterone (BT) or free testosterone (FT) levels is currently considered the gold standard for the diagnosis of androgen deficiency in elderly men. While the impact of age on circulating testosterone levels (total, bioavailable and free) has been strongly documented, the exi...


    pub_type: 杂志文章


    authors: Tancredi A,Reginster JY,Luyckx F,Legros JJ

    更新日期:2005-08-01 00:00:00

  • Physical activity and cortisol in anorexia nervosa.

    abstract::Elevated physical activity is commonly observed among patients with Anorexia Nervosa (AN) and can manifest in several forms. While elevated physical activity may play a key role in the pathophysiology of this disorder, much remains unknown about it, including the relationship among its various manifestations, and thei...


    pub_type: 杂志文章


    authors: Klein DA,Mayer LE,Schebendach JE,Walsh BT

    更新日期:2007-06-01 00:00:00

  • High-dose naloxone (1.0 mg/kg): psychological and endocrine effects in normal male subjects pretreated with one milligram of dexamethasone.

    abstract::The possible participation of the endogenous opioid system (EOS) in the negative feedback of the hypothalamic-pituitary-adrenal axis (HPA-a) activated by low doses (1 mg) of dexamethasone (Dex) was investigated. Ten male healthy subjects (mean age 31.5 +/- 1.9 SEM) were studied on 2 separate days, in a double-blind, c...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Martín-Del-Campo AF,Cortés-Sotres J,Herrera-Ferrá K,Ulloa-Aguirre A

    更新日期:1998-05-01 00:00:00