Abstract：
BACKGROUND:Little is known of the association between thyroid hormones in the central nervous system and Alzheimer's disease (AD). We determined thyroid hormone levels in serum and cerebrospinal fluid (CSF) in a well-defined homogeneous mono-center population. METHODS:Fifty-nine consecutive patients under primary evaluation for cognitive impairment were recruited. The participants included patients with AD or mild cognitive impairment (MCI) diagnosed with AD upon follow-up (n=31), patients with stable MCI (SMCI, n=13), patients with other dementias (n=15), and healthy controls (n=19). Thyroid hormones in serum and CSF and AD biomarkers in CSF were analyzed using established immunochemical assays. Cognitive impairment was estimated using mini-mental state examination (MMSE). RESULTS:Serum levels of free and total thyroxine (T4) and triiodothyronine (T3) were similar in all groups whereas a marginal increase in serum thyroid-stimulating hormone (TSH) level was observed in the AD patients. The CSF level of total T4 was decreased in patients with AD and other dementias compared to SMCI (both P=0.01) and healthy controls (both P=0.001), whereas CSF levels of TSH and total T3 were unchanged. In the total study population, CSF total T4 level correlated positively with MMSE score (r=0.26, P<0.05) and negatively with CSF total-tau (T-Tau) level (r=-0.23, P<0.05). CONCLUSION:Patients with AD as well as other dementias had signs of mild brain hypothyroidism, which could only to a small extent be detected in serum values.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Johansson P,Almqvist EG,Johansson JO,Mattsson N,Hansson O,Wallin A,Blennow K,Zetterberg H,Svensson Jdoi
10.1016/j.psyneuen.2012.10.012subject
Has Abstractpub_date
2013-07-01 00:00:00pages
1058-66issue
7eissn
0306-4530issn
1873-3360pii
S0306-4530(12)00347-2journal_volume
38pub_type
杂志文章abstract：:The translocator protein 18 kDa (TSPO), initially characterized as peripheral benzodiazepine receptor, is a conserved outer mitochondrial membrane protein, implicated in cholesterol transport thereby affecting steroid hormone biosynthesis, as well as in general mitochondrial function related to bioenergetics, oxidativ...
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pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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