Abstract：
:Exposure to chronic stress is thought to play an important role in the etiology of depression. In this disorder, a disrupted negative feedback response to exogenous glucocorticoids on cortisol secretion has been indicated. However, the regulation of glucocorticoid negative feedback by chronic stress is not fully understood. In the present study, we investigated the effects of chronic stress administered by water immersion and restraint (2 h/day) for four weeks on the glucocorticoid feedback in rats. In the acutely (one-time) stressed rats, the basal plasma corticosterone (CORT) level was markedly elevated, remained at high levels for 5 h after the termination of stress, and then decreased. In the chronically stressed rats, the CORT level was initially elevated similarly, but rapidly decreased at 2 h. In the dexamethasone (DEX) suppression test, the peak CORT level in response to stress was not suppressed by DEX in the acutely stressed rats, but was significantly suppressed in the chronically stressed rats. In contrast, the suppressive effects of DEX on the basal CORT secretion in naive rats were attenuated in the chronically stressed rats. In the chronically stressed hippocampus, which plays an important role in the regulation of the glucocorticoid feedback response, the binding of [3H]DEX was decreased and the increased response of activator protein-1 induced by acute stress was abolished. These results suggest that chronic stress induces a hypersuppressive state for induced CORT secretion in response to acute stress, which is caused by partial habituation, coping, and adaptation to the stressor, whereas it induces a hyposuppressive state for the basal CORT secretion, which is caused by glucocorticoid receptor downregulation. These mechanisms may be involved in the stress-induced neural abnormalities observed in depression.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Mizoguchi K,Yuzurihara M,Ishige A,Sasaki H,Chui DH,Tabira Tdoi
10.1016/s0306-4530(01)00004-xkeywords:
subject
Has Abstractpub_date
2001-07-01 00:00:00pages
443-59issue
5eissn
0306-4530issn
1873-3360pii
S0306-4530(01)00004-Xjournal_volume
26pub_type
杂志文章abstract：:Chronic stress contributes to many neuropsychiatric disorders in which the HPA axis, cognition and neuro-immune activity are dysregulated. Patients with major depression, or healthy individuals subjected to acute stress, present elevated levels of circulating pro-inflammatory markers. Acute stress also activates pro-i...
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pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章,随机对照试验
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2016.02.010
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2012.01.001
更新日期：2012-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2010-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2015.12.021
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pub_type： 临床试验,杂志文章
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更新日期：2005-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2016.10.017
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2013.02.004
更新日期：2013-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2011.02.018
更新日期：2011-10-01 00:00:00
abstract：:Recent evidence suggests that testosterone is negatively correlated with empathic processes in both men and women. Also, administration of testosterone to young women impairs socio-cognitive performance as assessed using the "Reading the Mind in the Eyes Task", especially among those exposed to elevated testosterone c...
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pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
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pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
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更新日期：2003-05-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2001-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2009.05.012
更新日期：2009-12-01 00:00:00
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更新日期：2016-06-01 00:00:00
