Abstract:
BACKGROUND:Hair cortisol concentrations (HCC) are increasingly used as a biomarker of stress, however limited research exists regarding the relationship between HCC and protective factors, such as resilience. Additionally, studies measuring HCC need to account for possible confounders, and these factors have not been examined in sufficiently diverse settings. OBJECTIVES:Our objectives were to identify determinants of HCC in a sample of mixed ancestry adults and investigate the association of HCC with measures of self-perceived stress and resilience. METHODS:Our sample comprised 164 females (mean age 46.5 years, SD = 15.0), self-identifying as mixed ancestry, who were control participants in a case-control study (SHARED ROOTS), conducted in Cape Town, South Africa from May 2014 until June 2017. We examined which socio-demographic, hair related, clinical and behavioural factors were associated with HCC in both unadjusted and adjusted linear regression models. Furthermore, the relationship of HCC with self-perceived stress and resilience scores were also examined. RESULTS:HCC (Mdn 4.4 pg/ml; IQR 2.8; 11.4) were significantly positively associated with hair product use and breastfeeding, and significantly negatively associated with age, level of education, duration of sun exposure, duration of storage, and demonstrated a trend towards significance with frequency of hair washing, in adjusted models. HCC were inversely associated with CD-RISC scores (adj β = -0.179, p = 0.012) but were not significantly associated with PSS scores (adj β = -0.001, p = 0.989). CONCLUSIONS:We identified specific determinants of HCC in our sample, including the first indication that sun exposure has an effect on HCC under naturalistic conditions. These potential confounders need to be controlled for in the design and analysis of future studies. HCC may be a biomarker of resilience to stress, rather than perceived stress. Further research measuring HCC in more diverse settings and populations and including constructs related to resilience are needed.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
van den Heuvel LL,Acker D,du Plessis S,Stalder T,Suliman S,Thorne MY,Kirschbaum C,Seedat Sdoi
10.1016/j.psyneuen.2019.104543subject
Has Abstractpub_date
2020-03-01 00:00:00pages
104543eissn
0306-4530issn
1873-3360pii
S0306-4530(19)31284-3journal_volume
113pub_type
杂志文章abstract:INTRODUCTION:Bipolar disorder (BD) and schizophrenia (SCZ) are psychiatric disorders with shared and distinct clinical and genetic features. In both disorders, stress increases the risk for onset or relapse and dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis has been reported. The latter is frequently in...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2016.03.010
更新日期:2016-07-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
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abstract:BACKGROUND:Past studies investigating the link between mindfulness and stress responding (i.e., emotional, psychological, and physiological responses to perceived threat or challenge) have focused on mindfulness training and on adult populations. In addition, research has not directly examined whether high mindfulness ...
journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
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abstract::Cognitive impairment has long been recognized as central to the abnormalities that occur in schizophrenia, since neurocognitive deficits are predictive of a number of outcome indices, and they pose a significant obstacle to any attempts at social rehabilitation. This raises the possibility that treatments producing im...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
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abstract::Recent evidence suggests that poor sleep is a potential pathway underlying the association between stressful experiences and the diurnal cortisol profile. However, existing findings are largely limited to adults. The present study examines whether poor sleep (duration, quality) mediates the relation between stressful ...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2015.03.006
更新日期:2015-07-01 00:00:00
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.06.006
更新日期:2019-10-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2011.03.006
更新日期:2011-10-01 00:00:00
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journal_title:Psychoneuroendocrinology
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更新日期:1995-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2020.104657
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2017.01.023
更新日期:2017-04-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2012.10.018
更新日期:2013-07-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2020.104777
更新日期:2020-10-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
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更新日期:2017-03-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.03.030
更新日期:2019-08-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2018.09.038
更新日期:2019-02-01 00:00:00
abstract::Recent studies indicate the presence of adenosine binding sites in rat pinealocytes and an effect of their activation on pineal serotonin metabolism. However, controversial data exist, and reports suggest that the role of adenosine in pineal physiology is complex. On this basis, we evaluated the effects of an adenosin...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(92)90064-e
更新日期:1992-05-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.psyneuen.2013.02.010
更新日期:2013-07-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2017.03.010
更新日期:2017-06-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2017.09.011
更新日期:2017-12-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(89)90033-4
更新日期:1989-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2018.10.017
更新日期:2019-03-01 00:00:00
abstract::ACTH secretion is primarily controlled by hypothalamic secretion of corticotropin releasing factor (CRF) into pituitary portal blood. However arginine vasopressin (AVP) and oxytocin (OT) can modulate the actions of CRF and at times may be important mediators of stress-induced ACTH secretion. The relative contributions...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/0306-4530(86)90048-x
更新日期:1986-01-01 00:00:00
abstract::Previous research links contemplative practices, such as meditation, with stress reduction. However, little is known about the psychological mechanisms underlying this relationship. This study compares the physiological stress response (reactivity and recovery) measured by changes in salivary cortisol, heart rate, hea...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.02.026
更新日期:2019-06-01 00:00:00
abstract::The hypothalamic hormone oxytocin (OXT) plays an important role in a range of physiological processes and social-emotional functioning in both sexes. In women, physiological stimuli, such as suckling and parturition, result in pulsatile release of OXT into the peripheral circulation via the posterior pituitary gland. ...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2017.07.486
更新日期:2017-11-01 00:00:00
abstract::The peptide hormone oxytocin (OT) plays an important role in social behaviors, including social bond formation. In different contexts, however, OT is also associated with aggression, social selectivity, and reduced affiliation. Female meadow voles form social preferences for familiar same-sex peers under short, winter...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2016.02.025
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Hypothalamus-Pituitary-Adrenal (HPA) axis dysregulation is often seen in major depression, and is thought to represent a trait vulnerability - rather than merely an illness marker - for depressive disorder and possibly anxiety disorder. Vulnerability traits associated with stress-related disorders might refl...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2010.07.014
更新日期:2011-02-01 00:00:00
abstract::Previous studies have shown that 17beta-estradiol (E2) induces antidepressant-like actions per se and potentiates those produced by fluoxetine (FLX) in the forced swimming test (FST). The aim of the present work was to explore the participation of serotonin 1A receptors (5-HT1A) and estrogen receptors (ERs) in the ant...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2006.05.001
更新日期:2006-09-01 00:00:00
abstract::Heightened cortisol levels due to stress or acute administration seem to enhance memory for emotional material, independently of emotional valence. An arousal-driven neurobiological mechanism involving the amygdala has been proposed. The relation between pre-task salivary measures of cortisol (by convention named 'bas...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/s0306-4530(02)00116-6
更新日期:2003-10-01 00:00:00