Abstract:
:In psychiatry, neuroendocrine techniques were initially considered a potential "window into the brain" by indirectly marking central nervous system limbic dysfunction. At present this conception has evolved, owing to significant progress over the last decades demonstrating direct involvement of neuropeptides and neurohormones in psychiatric diseases. In a synchronic perspective, neuroendocrine investigations evaluate a functional status at a given moment in the evolution of the disease, which results from both etiopathogenic processes and compensatory homeostatic mechanisms. These vital physiological changes appear to be potential targets for novel hormonally based pharmacotherapies. However, in the past few years, the interest for the study of neuroendocrine dysregulations in psychiatric patients has declined. In order to better understand this relative disinterest, this article will attempt to shed light on strengths and limitations of the neuroendocrine approaches in psychiatry. It is necessary to bear in mind that the usefulness of these techniques in the clinical, pathophysiological and therapeutic fields depends largely on the selectivity of stimuli and the appropriateness of the methodologies used. Owing to the complexity of the clinical phenomena, multifactorial approaches (combining several neuroendocrine challenge tests to imaging, immunological, neurophysiological, neurochemical and/or genetic techniques) are to be privileged in psychiatric investigations. Despite the inherent limitations of these approaches, due to their technical and ethical constraints, the neuroendocrine strategy can inform modern clinical practice and lead to new breakthroughs in future science and practice.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Duval F,Mokrani MC,Crocq MAdoi
10.1016/j.psyneuen.2013.04.012subject
Has Abstractpub_date
2013-08-01 00:00:00pages
1213-9issue
8eissn
0306-4530issn
1873-3360pii
S0306-4530(13)00150-9journal_volume
38pub_type
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,随机对照试验
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更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2007.11.016
更新日期:2008-04-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00