Abstract：
OBJECTIVE:Posttraumatic stress symptoms (PTSS) are commonly associated with impairments in extinguishing fear to signals previously associated with danger, and also with inhibiting fear to safety signals. Previous studies indicate that PTSS are associated with low cortisol activity, and cortisol is shown to facilitate fear extinction. Few studies have examined the influence of cortisol reactivity on fear extinction in PTSS. METHOD:We used a standardized fear conditioning and extinction paradigm to investigate the relationship between fear extinction and endogenous salivary cortisol activity in participants with high PTSS (n=18), trauma-exposed controls (n=33), and non-trauma-exposed controls (n=27). Skin conductance response (SCR) was used as an index of conditioned responding. Saliva samples were collected at baseline, and 20min post-fear acquisition for basal and reactive cortisol levels, respectively. RESULTS:PTSS participants demonstrated a slower rate of extinction learning during the early extinction phase. A moderation analysis revealed that cortisol reactivity was a significant moderator between fear inhibition to the safety signal (CS-) during early extinction and PTSS, but not to the threat signal (CS+). Specifically, this interaction was significant in two ways: (1) participants with elevated cortisol reactivity showed lower PTSS as fear inhibition improved; and (2) participants with low cortisol reactivity showed higher PTSS as fear inhibition improved. CONCLUSION:The findings of the present study show that the relationship between fear inhibition and cortisol reactivity is complex, and suggest that cortisol reactivity shapes safety signal learning in PTSS.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Zuj DV,Palmer MA,Malhi GS,Bryant RA,Felmingham KLdoi
10.1016/j.psyneuen.2017.01.012subject
Has Abstractpub_date
2017-04-01 00:00:00pages
14-21eissn
0306-4530issn
1873-3360pii
S0306-4530(16)30764-8journal_volume
78pub_type
杂志文章abstract：:We have studied the effects of ketanserin, a specific 5-HT2 antagonist, and zimelidine, a selective inhibitor of 5-HT re-uptake into central nervous system presynaptic terminals, upon basal and TRH stimulated serum TSH and prolactin levels in euthyroid individuals. Ten normal volunteers were studied (five male and fiv...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(84)90017-9
更新日期：1984-01-01 00:00:00
abstract：BACKGROUND:Childhood adversity is a robust predictor of poor health outcomes in adulthood and hypothalamic-pituitary-adrenocortical (HPA) axis dysfunction may be a key mechanism explaining this association. However, little is known about the influence childhood adversity may exhibit on adult HPA axis habituation (i.e.,...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2020.105118
更新日期：2020-12-24 00:00:00
abstract：:Central dopaminergic dysfunction has been suggested to be involved in the pathogenesis of obsessive compulsive disorder (OCD). In 15 patients with OCD and in 15 age-sex matched controls we evaluated the dopamine (DA) function by measuring the cortisol (CORT) responses to stimulation with the DA agonist apomorphine (AP...
journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/s0306-4530(99)00061-x
更新日期：2000-04-01 00:00:00
abstract：:For the measurement of salivary alpha-amylase (sAA) activity, saliva samples first have to be diluted. There is some evidence for instability, that is, a decline of sAA activity in diluted samples. It is not clear which factors during dilution may contribute to this phenomenon and how quickly this decline of sAA activ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2020.104847
更新日期：2020-11-01 00:00:00
abstract：:Using the learned helplessness model of depression in rats, the present study undertook to investigate the possibility of an impaired response to antidepressant drugs in diabetic animals. Experimental diabetes was induced by three intraperitoneal (IP) injections of streptozotocin (37.5, 37.5, 50 mg/kg, three days apar...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(89)90064-4
更新日期：1989-01-01 00:00:00
abstract：:Cognitive decline in old age is not universal or inevitable. Associations have been observed with neuroendocrine function, but the relevance of other physiological processes is unclear. We predicted that impairment of memory in an ageing population would be related to the dysregulation of neuroendocrine and cardiovasc...
journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/j.psyneuen.2005.04.001
更新日期：2005-10-01 00:00:00
abstract：OBJECTIVE:To investigate the neuroendocrinological stress response to acute psychosocial stress in a clinical sample of female adolescents engaging in nonsuicidal self-injury (NSSI). METHODS:The Trier Social Stress Test (TSST), a standardized psychosocial stress protocol, was performed in 14 female patients who engage...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2011.05.009
更新日期：2012-01-01 00:00:00
abstract：:The current study investigated the associations between thyroid stimulating hormone (TSH), free thyroxine (T(4)) and cognitive ability (general ability, memory and processing speed), in a large age homogenous sample (n=659) of generally healthy euthyroid older adults. Associations were considered both at baseline (mea...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2012.07.018
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Subliminal intragastric fatty acid infusion attenuates subjective and brain responses to negative emotion induction. However, the underlying gut-brain signaling mechanisms remain unclear, and it is unknown whether such effect equally applies to positive emotion. OBJECTIVE:We aimed to investigate the interac...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2019.06.010
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:A proportion of patients with panic disorder (PD) fail to show a remission after psychotherapy. Biological correlates of psychotherapy non-response have rarely been described in the literature. The aim of the present study was to research the relationship between the cortisol stress response and the psychoth...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2016.11.030
更新日期：2017-03-01 00:00:00
abstract：:Estrogen-induced synaptic plasticity was frequently shown by an increase of spines at apical dendrites of CA1 pyramidal neurons after systemic application of estradiol to ovariectomized rats. Surprisingly, exogenous application of estradiol to hippocampal cultures had no effect on spines and on spine synapses, althoug...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.psyneuen.2009.08.013
更新日期：2009-12-01 00:00:00
abstract：:The science of neuroimmunopsychiatry has evolved rapidly in the last few years with the hope of tackling the unmet need in mood disorders. This article focuses on an inflammatory pathway, highly conserved in myeloid cells that may play a role in neuroinflammatory disorders including depression. Within the brain tissue...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.psyneuen.2018.08.015
更新日期：2018-12-01 00:00:00
abstract：:Swim stress regulates forebrain 5-hydroxytryptamine (5-HT) release in a complex manner and its effects are initiated in the serotonergic dorsal raphe nucleus (DRN). The purpose of this study was to examine the effects of swim stress on the physiology of DRN neurons in conjunction with 5-HT immunohistochemistry. Basic ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2007.05.001
更新日期：2007-07-01 00:00:00
abstract：:Psychosocial stress is a potent activator of the hypothalamus-pituitary-adrenal (HPA) axis. While the physiological mechanisms of HPA axis responses to stress as well as its short and long-term consequences have been extensively examined, less is known why someone elicits an acute neuroendocrine stress response, i.e. ...
journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/j.psyneuen.2005.02.001
更新日期：2005-07-01 00:00:00
abstract：:The endocannabinoid system has been implicated in the regulation of the stress response, fear memory formation, and inflammatory processes. Posttraumatic stress disorder (PTSD) can result from exposure to extreme stress and is characterized by strong, associative memories for the traumatic events experienced. Furtherm...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2016.02.010
更新日期：2016-05-01 00:00:00
abstract：CONTEXT:The rise of cortisol concentrations after awakening is well documented in adults and children and commonly used as easily accessible marker of hypothalamic-pituitary-adrenal (HPA) reactivity. OBJECTIVE:The purpose of this study was to demonstrate the existence of a salivary cortisol awakening response (CAR) in...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2012.08.002
更新日期：2013-05-01 00:00:00
abstract：:Disturbances of volume regulating peptides like vasopressin and atrial natriuretic peptide (ANP) have been described in early abstinent patients. Aim of the present study was to evaluate possible alterations of the promoter-related DNA methylation of the ANP and vasopressin precursor genes and the related mRNA-express...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2008.10.019
更新日期：2009-05-01 00:00:00
abstract：:Nesfatin-1 has been discovered a decade ago and since then drawn a lot of attention. The initially proposed anorexigenic effect was followed by the description of several other involvements such as a role in gastrointestinal motility, glucose homeostasis, cardiovascular functions and thermoregulation giving rise to a ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.psyneuen.2018.09.037
更新日期：2019-02-01 00:00:00
abstract：:The normal diurnal cortisol cycle has a peak in the morning, decreasing rapidly over the day, with low levels during the night, then rising rapidly again to the morning peak. A pattern of flatter daytime slopes has been associated with more rapid cancer progression in both animals and humans. We studied the relationsh...
journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/j.psyneuen.2006.09.004
更新日期：2006-11-01 00:00:00
abstract：:Depression is a common problem in multiple sclerosis (MS) and affects about 50% of MS patients. Since a dysregulation of cytokine levels has been implicated in the pathogenesis of MS and alterations in cytokine serum levels have been found in depressive illness, we examined the relationship between depressive symptoms...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/s0306-4530(01)00068-3
更新日期：2002-08-01 00:00:00
abstract：OBJECTIVES:Exposure to adversity has been linked to accelerated biological aging, which in turn has been shown to predict numerous physical and mental health problems. In recent years, measures of DNA methylation-based epigenetic age--known as "epigenetic clocks"--have been used to estimate accelerated epigenetic aging...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2019.104484
更新日期：2020-03-01 00:00:00
abstract：:The relationships between positive emotional style and acute salivary cortisol and cardiovascular responses to laboratory stress tasks were examined in 40 young women (mean age=28.8 years). Positive emotional style (PES) was measured by aggregating daily positive mood rating scales over one week. Negative affect was a...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2011.02.009
更新日期：2011-09-01 00:00:00
abstract：:Corticosteroids from the adrenal cortex influence a variety of behaviours including cognition, learning and memory. These hormones act via two intracellular receptors, the mineralo-corticoid receptor (MR) and the glucocorticoid receptor (GR). These two receptor types display a high concentration and distinct distribut...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/s0306-4530(97)00091-7
更新日期：1998-01-01 00:00:00
abstract：:Interpersonal touch is frequently used for communicating emotions, strengthen social bonds and to give others pleasure. The neuropeptide oxytocin increases social interest, improves recognition of others' emotions, and it is released during touch. Here, we investigated how oxytocin and gentle human touch affect social...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2013.09.017
更新日期：2014-01-01 00:00:00
abstract：:Despite the high prevalence of neural and immune disorders, their etiology and molecular mechanisms remain poorly understood. As the zebrafish (Danio rerio) is increasingly utilized as a powerful model organism in biomedical research, mounting evidence suggests these fish as a useful tool to study neural and immune me...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.psyneuen.2018.03.014
更新日期：2018-06-01 00:00:00
abstract：:Previous studies with prairie voles suggest that the hormone oxytocin is crucial for bond formation - indicated when a partner preference is formed towards the target vole. In this study, we conduct the first empirical test of whether oxytocin likewise promotes partner preferences in humans. Seventy-six undergraduate ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2012.07.009
更新日期：2013-04-01 00:00:00
abstract：:Neurobehavioral symptoms are frequently reported in patients with diabetes. Nevertheless, the characterization of the specific symptom dimensions that develop in diabetic patients with respect to disease phenotype and treatment status remains obscure. This study comparatively assessed fatigue symptoms and cognitive pe...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2012.01.016
更新日期：2012-09-01 00:00:00
abstract：:It is widely assumed that learning and memory processes play an important role in the pathogenesis, expression, maintenance and therapy of anxiety disorders, such as phobias or post-traumatic stress disorder (PTSD). Memory retrieval is involved in symptom expression and maintenance of these disorders, while memory ext...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2012.12.018
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Flibanserin, a novel serotonin (5-HT)(1A) agonist and 5-HT(2A) antagonist, has been shown to increase sexual desire and reduce distress in women with Hypoactive Sexual Desire Disorder (HSDD). In marmoset monkeys, flibanserin has demonstrated pro-social effects on male-female pairmates, while the classic 5-HT...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2012.05.011
更新日期：2013-01-01 00:00:00
abstract：:The possible participation of the endogenous opioid system (EOS) in the negative feedback of the hypothalamic-pituitary-adrenal axis (HPA-a) activated by low doses (1 mg) of dexamethasone (Dex) was investigated. Ten male healthy subjects (mean age 31.5 +/- 1.9 SEM) were studied on 2 separate days, in a double-blind, c...
journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0306-4530(98)00002-x
更新日期：1998-05-01 00:00:00
