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Steroid-induced elevation of glucose in Alzheimer's disease: relationship to gender, apolipoprotein E genotype and cognition.

Abstract：

:Glucose and insulin may play an important role in the pathophysiology and symptomatology of Alzheimers disease (AD), and prior studies suggest interactions among glucose, insulin, gender and apolipoprotein E genotype. We analyzed the relationship between steroid-induced glucose elevation and gender, presence of the apolipoprotein E epsilon 4 (APOE-4) allele and cognition using data from a multicenter trial of prednisone therapy in AD. The low-dose prednisone regimen (initial dose: 20 mg/day, maintenance dose: 10 mg/day) caused a moderate increase in random blood glucose (mean post-baseline glucose 115 mg/dl). There was a significant interaction between rise in glucose, gender and presence of the APOE-4 allele. There was no important relationship between glucose and cognitive function at baseline or with prednisone treatment. Meta-analysis including data from three other AD trials showed a small influence of random blood glucose on cognitive scores. These results support a relationship between gender, apolipoprotein E genotype and glucose metabolism, but do not indicate that mild changes in glucose have an important impact on cognitive function.

journal_name

Psychoneuroendocrinology

journal_title

Psychoneuroendocrinology

authors

Aisen PS,Berg JD,Craft S,Peskind ER,Sano M,Teri L,Mulnard RA,Thomas RG,Thal LJ

doi

10.1016/s0306-4530(02)00015-x

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

113-20

issue

1

eissn

0306-4530

issn

1873-3360

pii

S030645300200015X

journal_volume

28

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

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