Abstract：
:Possible sex differences in the balance between dopaminergic and cholinergic activity in the rat striatum were investigated. Female rat show a greater vulnerability to neuroleptic-induced catalepsy compared to male rats. This vulnerability to neuroleptics has a human counterpart in that women show an increased frequency of neuroleptic-induced extrapyramidal syndrome (EPS) compared to men. In humans, EPS can be alleviated by increasing dopaminergic activity or by decreasing cholinergic activity. Conversely, EPS can be precipitated by decreasing dopaminergic activity with neuroleptics, and pre-existing EPS can be made worse with cholinergic agonists. Thus, the presence of EPS in humans or catalepsy in animals, as a result of neuroleptic agents, appears to be related to low dopaminergic and/or high cholinergic activity. In the present studies of sex differences it was found that: (1) cycling female rats had fewer striatal dopamine receptors than did male rats. Estradiol treatment significantly reduced the number in males and also reduced the number, although not significantly in ovariectomized (OVX) rats; (2) cycling female rats had lower apomorphine-induced stereotypy during phases with high estrogen levels as compared to phases with low estrogen levels. Estrogen treatment of male or OVX rats resulted in attenuation of induced stereotypy compared to untreated male or OVX rats; (3) female rats had a significantly higher affinity of striatal cholinergic receptors of 3H-QNB than did males and also had higher choline acetyltransfease activity than male rats. The data from these experiments provide the first direct evidence that estrogen plays a role in shifting the balance toward cholinergic predominance in the striatum, a state that favors the development of cataleposy in female rats and EPS in women.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Miller JCdoi
10.1016/0306-4530(83)90059-8subject
Has Abstractpub_date
1983-01-01 00:00:00pages
225-36issue
2eissn
0306-4530issn
1873-3360journal_volume
8pub_type
杂志文章,评审abstract：:The role of corticosteroids in brain aging remains a controversial issue. Conceivably, if corticosteroids levels are increased in the aged brain, neuronal function might be altered. For instance, GABA-mediated synaptic events, spike accommodation and afterhyperpolarizing potentials (AHPs) might be modified. Our electr...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/s0306-4530(97)00008-5
更新日期：1997-01-01 00:00:00
abstract：OBJECTIVE:There is evidence that microRNA-195 (miR-195) is associated with schizophrenia (SZ) and cognition, but the relationship between miR-195 and cognitive impairment in SZ is still unknown. Sex differences in both microRNA (miRNA) expression and cognition were found in SZ. We aim to investigate whether sex moderat...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2020.104748
更新日期：2020-09-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2007.09.002
更新日期：2007-09-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2018.06.020
更新日期：2018-10-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(88)90058-3
更新日期：1988-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2016.09.008
更新日期：2016-12-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2013.09.011
更新日期：2013-12-01 00:00:00
abstract：:The effects of corticosteroids on memory performance have been the subject of some controversy. Whilst many studies have shown that high levels of corticosteroids can impair memory performance, others have shown they can facilitate it. One explanation for these discrepant effects arises from the differential activatio...
journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/S0306-4530(03)00103-3
更新日期：2004-07-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2017.08.005
更新日期：2017-11-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2010.05.011
更新日期：2010-11-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/j.psyneuen.2004.06.004
更新日期：2005-02-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/j.psyneuen.2011.03.009
更新日期：2011-10-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2018.11.007
更新日期：2019-03-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2015.12.021
更新日期：2016-04-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2018.07.013
更新日期：2018-11-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2010.12.002
更新日期：2011-07-01 00:00:00
abstract：:In a controlled cross-over design study performed with 14 female subjects, serum hormone levels, the EEG and a number of performance tests were recorded during spontaneous and oral contraceptive-controlled menstrual cycles. The mean alpha-frequency showed cyclic changes, i.e. slower alpha-waves during the follicular p...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(82)90057-9
更新日期：1982-01-01 00:00:00
abstract：:A number of studies have now examined the association between smoking and the magnitude of physiological reactions to acute psychological stress. However, no large-scale study has demonstrated this association incorporating neuroendocrine in addition to cardiovascular reactions to stress. The present study compared ne...
journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/j.psyneuen.2014.05.023
更新日期：2014-10-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
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更新日期：2004-08-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2020.105124
更新日期：2020-12-29 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2017.01.022
更新日期：2017-04-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2018.11.040
更新日期：2019-04-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2014.12.020
更新日期：2015-03-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2019.06.009
更新日期：2019-10-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2012.05.015
更新日期：2013-01-01 00:00:00
abstract：:Orexigenic hormones are a group of hormones that can up-regulate appetite. Current studies have shown that orexigenic hormones also play important roles in stress responses and may be implicated in regulation of fear memory. However, these conclusions lack evidence from human studies. In this study, we examined associ...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2018.09.042
更新日期：2019-02-01 00:00:00
abstract：:This study was designed to investigate the relationship between selective attention to social threat and neuroendocrine activity. Selective attention to social threat was measured using a supraliminal (unmasked) and a subliminal (masked) version of a pictorial emotional Stroop task, comparing color-naming latencies of...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/s0306-4530(00)00011-1
更新日期：2000-08-01 00:00:00
abstract：:Attachment-based parenting interventions have shown positive effects on early cortisol regulation, a key biomarker. Evaluations to date have focused on diurnal cortisol production in high-risk infants. It is important to understand whether attachment-based intervention may also improve stress-induced cortisol producti...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2019.01.005
更新日期：2019-05-01 00:00:00
abstract：:Hyperactivity of the hypothalamic-pituitary-adrenal axis (HPAA) resulting from fetal programming may play a role in the development of high blood pressure (BP) in black people. We assessed the diurnal salivary cortisol profile in children with and without increased BP and evaluated their mother's HPAA. In a cross-sect...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2008.12.005
更新日期：2009-06-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2016.04.021
更新日期：2016-08-01 00:00:00
