Abstract:
BACKGROUND:Nightmares and insomnia in PTSD are hallmark symptoms, yet poorly understood in comparison to the advances toward a biological framework for the disorder. According to polysomnography (PSG), only minor changes in sleep architecture were described. This warrants alternative methods for assessing sleep regulation in PTSD. METHODS:After screening for obstructive sleep apnea and period limb movement disorder, veterans with PTSD (n=13), trauma controls (TCs, n=17) and healthy controls (HCs, n=15) slept in our sleep laboratory on two consecutive nights with an IV catheter out of which blood was sampled every 20min from 22:00h to 08:00h. Nocturnal levels of plasma adrenocorticotropic hormone (ACTH), cortisol, melatonin were assessed in conjunction with PSG registration, as well as subjective sleep parameters. RESULTS:PTSD patients showed a significant increase in awakenings during sleep in comparison to both control groups. These awakenings were correlated with ACTH levels during the night, and with the subjective perception of sleep depth. Also, heart rate (HR) was significantly increased in PTSD patients as compared with both control groups. The diurnal regulation of ACTH, cortisol and melatonin appeared undisturbed. PTSD patients exhibited lower cortisol levels at borderline significance (p=0.056) during the first half of the night. ACTH levels and cortisol levels during the first half of the night were inversely related to slow wave sleep (SWS). CONCLUSION:This study suggests that hypothalamo-pituitary-adrenal (HPA) axis activity is related to sleep fragmentation in PTSD. Also, activity of the sympathetic nervous system (SNS) is increased during sleep in PTSD. Further research is necessary to explore the potential causal relationship between sleep problems and the activity of the HPA-axis and SNS in PTSD.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
van Liempt S,Arends J,Cluitmans PJ,Westenberg HG,Kahn RS,Vermetten Edoi
10.1016/j.psyneuen.2012.05.015subject
Has Abstractpub_date
2013-01-01 00:00:00pages
155-65issue
1eissn
0306-4530issn
1873-3360pii
S0306-4530(12)00192-8journal_volume
38pub_type
杂志文章abstract::The two objectives of this study were: (1) to examine the impact of social interaction variables (e.g., friendship, time working together, and activity) on the occurrence of menstrual synchrony; (2) to examine the menstrual synchrony of women who work together in an office. The sample consisted of 72 women soldiers in...
journal_title:Psychoneuroendocrinology
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doi:10.1016/0306-4530(94)e0004-s
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abstract::Multiple lines of evidence indicate that patients with chronic schizophrenia (SCZ) display executive dysfunction across the illness course. However, the potential molecular pathophysiologic mechanisms remain poorly elucidated. Neurodevelopmental changes caused by alterations of inflammatory mediators and neurotrophins...
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2008.08.016
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abstract:OBJECTIVE:Major Depression (MD) results from a complex interplay between environmental stressors and biological factors. Previous studies in adults have shown that adverse life events interact with genetic variation in FKBP5, a gene implicated in the stress-response system, to predict depressive symptoms and MD. This i...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.03.025
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abstract::Sumoylation is a recently described post-translational modification and only a few sumoylated neurotransmitter receptors are known. Through the present studies, we discovered that serotonin1A receptors (5-HT1A-Rs) can be sumoylated by SUMO1 (small-ubiquitin-related modifier 1) protein. The SUMO1-5-HT1A-R is ∼55kDa, is...
journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(92)90050-h
更新日期:1992-05-01 00:00:00
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.03.010
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,meta分析
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2015.08.009
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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doi:10.1016/j.psyneuen.2016.03.018
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journal_title:Psychoneuroendocrinology
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pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.psyneuen.2015.10.011
更新日期:2016-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/0306-4530(91)90079-9
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2012.01.009
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
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更新日期:1997-08-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2018.09.015
更新日期:2019-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.psyneuen.2007.10.001
更新日期:2008-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,meta分析,评审
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更新日期:2014-04-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
doi:10.1016/j.psyneuen.2011.11.011
更新日期:2012-07-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
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更新日期:2002-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2011.04.001
更新日期:2011-11-01 00:00:00