Abstract:
:Cocaine stimulates the release of adrenocorticotropin hormone (ACTH) and cortisol in both clinical and preclinical studies, but the temporal sequence of cocaine-induced changes in other hormones and affective states is unclear. The purpose of this study was to analyze the pattern and temporal concordance of cocaine-induced changes in ACTH, cortisol, dihydroepiandrosterone (DHEA), epinephrine, heart rate and subjective reports of euphoria. Six healthy men who met Diagnostic and Statistical Manual-IV (DSM-IV) criteria for cocaine abuse provided informed consent for participation. Cocaine (0.4 mg/kg) or saline placebo was infused intravenously over 1 min under double-blind conditions. Euphoria, ACTH, epinephrine and heart rate increased significantly within 8 to 12 min after i.v. cocaine administration in all subjects (P<0.01-0.001). Moreover, the increases in euphoria, ACTH, epinephrine and heart rate each were significantly correlated with increases in plasma cocaine levels (P<0.001). Euphoria increased significantly within 2 min after i.v. cocaine injection, as plasma cocaine levels were increasing, and peak euphoria was reported at 10 min (P<0.001). Peak ACTH values were measured at 8.7 (+/-0.8) min after cocaine injection (P<0.01). Peak levels of epinephrine were measured at 10 (+/-1) min after cocaine injection (P<0.05). Peak increases in heart rate occurred at 11.7 (+/-1.1) min after cocaine injection (P<0.05). Peak levels of cortisol and DHEA were measured at 36 (+/-4.0) and 28.7 (+/-4.3) min after cocaine injection (P<0.01 and P<0.01). The temporal concordance between cocaine-induced stimulation of ACTH, epinephrine and subjective euphoria suggests that these hormonal changes are significant concomitants of the abuse-related effects of cocaine. The similarities between these hormonal profiles, the subjective effects of cocaine and the effects of "stress" are discussed.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Mendelson JH,Mello NK,Sholar MB,Siegel AJ,Mutschler N,Halpern Jdoi
10.1016/s0306-4530(01)00036-1keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
71-82issue
1-2eissn
0306-4530issn
1873-3360pii
S0306453001000361journal_volume
27pub_type
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,随机对照试验
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-11-01 00:00:00
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pub_type: 杂志文章
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