当前位置： SCI文献检索 > PSYCHONEUROENDOCRINOLOGY期刊下所有文献 > The effects of two different doses of hydrocortisone on cognition in patients with secondary adrenal insufficiency--results from a randomized controlled trial.

The effects of two different doses of hydrocortisone on cognition in patients with secondary adrenal insufficiency--results from a randomized controlled trial.

Abstract：

CONTEXT:A wide variety in hydrocortisone (HC) substitution dose-regimens are considered physiological for patients with secondary adrenal insufficiency (SAI). However, it is likely that cognition is negatively influenced by higher cortisol exposure to the brain. OBJECTIVE:To examine the effects of a high physiological HC dose in comparison to a low physiological HC dose on cognition. DESIGN AND SETTING:This study was a randomized double blind cross-over study at the University Medical Center Groningen. This study is registered with ClinicalTrials.gov, number NCT01546922. PATIENTS:Forty-seven patients (29 males, 18 females; mean [SD] age, 51 [14] years, range 19-73) with SAI participated. INTERVENTION(S):Patients randomly received first a low dose of HC (0.2-0.3 mg/kg body weight/day) during 10 weeks followed by a high dose (0.4-0.6 mg/kg body weight/day) for another 10 weeks, or vice versa. HC substitution was given in three divided doses with the highest dose in the morning. MAIN OUTCOME MEASURE(S):Cognitive performance (memory, attention, executive functioning and social cognition) of patients was measured at baseline and after each treatment period using a battery of 12 standardized cognitive tests. RESULTS:The higher dose of HC resulted in significantly higher systemic cortisol exposure for example measured at 1h after first dose ingestion (mean [SD], low dose: 653 [281] nmol/L; high dose: 930 [148] nmol/L; P<0.001). No differences in cognitive performance were found between the two dose regimens. CONCLUSIONS:No negative influence on memory, attention, executive functioning and social cognition was observed after 10 weeks of treatment with a higher physiological dose of HC in patients with SAI when compared to a lower dose.

journal_name

Psychoneuroendocrinology

journal_title

Psychoneuroendocrinology

authors

Werumeus Buning J,Brummelman P,Koerts J,Dullaart RP,van den Berg G,van der Klauw MM,Tucha O,Wolffenbuttel BH,van Beek AP

doi

10.1016/j.psyneuen.2015.02.001

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

36-47

eissn

0306-4530

issn

1873-3360

pii

S0306-4530(15)00051-7

journal_volume

55

pub_type

杂志文章,随机对照试验

相关文献

PSYCHONEUROENDOCRINOLOGY文献大全
  • PUFA induce antidepressant-like effects in parallel to structural and molecular changes in the hippocampus.

    abstract：:Epidemiological data suggest that omega-3 polyunsaturated fatty acids (PUFA) consumption may be inversely correlated to the prevalence and severity of depression but little is known about the underlying mechanisms. In this study, we experimentally investigated whether a chronic supplementation with PUFA may induce ant...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2008.08.025

    authors： Venna VR,Deplanque D,Allet C,Belarbi K,Hamdane M,Bordet R

    更新日期：2009-02-01 00:00:00

  • Changes in physiological, EEG and psychological parameters in women during the spontaneous menstrual cycle and following oral contraceptives.

    abstract：:In a controlled cross-over design study performed with 14 female subjects, serum hormone levels, the EEG and a number of performance tests were recorded during spontaneous and oral contraceptive-controlled menstrual cycles. The mean alpha-frequency showed cyclic changes, i.e. slower alpha-waves during the follicular p...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/0306-4530(82)90057-9

    authors： Becker D,Creutzfeldt OD,Schwibbe M,Wuttke W

    更新日期：1982-01-01 00:00:00

  • Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children.

    abstract：OBJECTIVES:Exposure to adversity has been linked to accelerated biological aging, which in turn has been shown to predict numerous physical and mental health problems. In recent years, measures of DNA methylation-based epigenetic age--known as "epigenetic clocks"--have been used to estimate accelerated epigenetic aging...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2019.104484

    authors： Marini S,Davis KA,Soare TW,Zhu Y,Suderman MJ,Simpkin AJ,Smith ADAC,Wolf EJ,Relton CL,Dunn EC

    更新日期：2020-03-01 00:00:00

  • Immobilization-induced stress decreases lipogenesis in sebaceous glands as well as plasma testosterone levels in male Syrian hamsters.

    abstract：:The effects of immobilization-induced stress on plasma testosterone levels and lipogenesis in the sebaceous gland were examined in male Syrian hamsters. To induce immobilization stress, the animals were placed in the prone position and wrapped with flexible steel wire gauze at room temperature. Plasma testosterone lev...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/0306-4530(94)00055-f

    authors： Tsuchiya T,Horii I

    更新日期：1995-01-01 00:00:00

  • Brain sensitization to external and internal stimuli.

    abstract：:Sensitization is defined as a non-associative learning process occurring when repeated administrations of a stimulus result in a progressive amplification of a response (Shettleworth, 2010). The purpose of this review paper is to discuss whether brain sensitization is helpful in common health problems in man. The pape...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.psyneuen.2014.01.008

    authors： Ursin H

    更新日期：2014-04-01 00:00:00

  • Frontal brain asymmetry, childhood maltreatment, and low-grade inflammation at midlife.

    abstract：:Frontal EEG asymmetry is thought to reflect variations in affective style, such that greater relative right frontal activity at rest predicts enhanced emotional responding to threatening or negative stimuli, and risk of depression and anxiety disorders. A diathesis-stress model has been proposed to explain how this ne...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2016.10.026

    authors： Hostinar CE,Davidson RJ,Graham EK,Mroczek DK,Lachman ME,Seeman TE,van Reekum CM,Miller GE

    更新日期：2017-01-01 00:00:00

  • Disgust affects TNF-alpha, IL-6 and noradrenalin levels in patients with obsessive-compulsive disorder.

    abstract：:Neurobiological research of obsessive-compulsive disorder (OCD) has rarely taken in account the context dependent evocation of obsessive-compulsive symptoms. To bypass this obstacle, this study investigated neurobiological parameters during a standardized disgust provocation paradigm in patients with OCD and healthy c...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2009.12.005

    authors： Fluitman SB,Denys DA,Heijnen CJ,Westenberg HG

    更新日期：2010-07-01 00:00:00

  • Reduced dopamine function in depressed patients is related to suicidal behavior but not its lethality.

    abstract：:Several lines of evidence suggest a role for dopamine in the control of suicidal behaviour. Previously, we suggested an involvement of D2-dopaminergic function in the biology of suicide by demonstrating a smaller growth hormone (GH) response to apomorphine, a dopaminergic agonist, in depressed patients who later died ...

    journal_title：Psychoneuroendocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0306-4530(01)00021-x

    authors： Pitchot W,Hansenne M,Gonzalez Moreno A,Pinto E,Reggers J,Fuchs S,Pirard S,Ansseau M

    更新日期：2001-10-01 00:00:00

  • Interleukin-1 receptor type 1-deficient mice fail to develop social stress-associated glucocorticoid resistance in the spleen.

    abstract：:Frequent or chronic stress as a result of repeated or persistent exposure to social challenges has been shown to affect the glucocorticoid (GC) responsiveness of immune cells in mice. Lipopolysaccharide-stimulated splenocytes of mice that were repeatedly subjected to social disruption were less sensitive to the anti-i...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2007.10.007

    authors： Engler H,Bailey MT,Engler A,Stiner-Jones LM,Quan N,Sheridan JF

    更新日期：2008-01-01 00:00:00

  • Effect of codeine and oxazepam on afternoon cortisol secretion in men.

    abstract：:The objective of this study was to investigate the effects of oral codeine and oxazepam on afternoon cortisol secretion. Nine subjects received either oxazepam (30 mg) or codeine (30 mg) or placebo at 1700h on separate days in a counterbalanced design; the subjects were not aware of the sequence. Blood samples were co...

    journal_title：Psychoneuroendocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0306-4530(89)90009-7

    authors： Garland EJ,Zis AP

    更新日期：1989-01-01 00:00:00

  • The social curse: Evidence for a moderating effect of shared social identity on contagious stress reactions.

    abstract：:Contagious stress describes the transmission of a stress response from a distressed individual (target) to an uninvolved observer. Building on social identity theory, we hypothesize that a shared social identity between the observer and the target as compared to a personal identity increases the likelihood of contagio...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2020.104896

    authors： Schury VA,Nater UM,Häusser JA

    更新日期：2020-12-01 00:00:00

  • Hypertonic saline infusion increases plasma norepinephrine concentrations in normal men.

    abstract：:We recently demonstrated in patients with panic disorder that hypertonic saline infusion induces acute panic with the same frequency and intensity as the standard hypertonic sodium lactate infusion. We now report the effects in normal men of hypertonic saline infusion on neuroendocrine systems possibly relevant to pan...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/0306-4530(93)90061-o

    authors： Peskind ER,Radant A,Dobie DJ,Hughes J,Wilkinson CW,Sikkema C,Veith RC,Dorsa DM,Raskind MA

    更新日期：1993-01-01 00:00:00

  • Flattened cortisol rhythms in metastatic breast cancer patients.

    abstract：:Allostatic load, the physiological accumulation of the effects of chronic stressors, has been associated with multiple adverse health outcomes. Flattened diurnal cortisol rhythmicity is one of the prototypes of allostatic load, and has been shown to predict shorter survival among women with metastatic breast cancer. T...

    journal_title：Psychoneuroendocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.psyneuen.2003.11.003

    authors： Abercrombie HC,Giese-Davis J,Sephton S,Epel ES,Turner-Cobb JM,Spiegel D

    更新日期：2004-09-01 00:00:00

  • The fountain of mental youth. Search for homeostatic and adaptational hormonal processes.

    abstract：:Successful mental aging may be defined as maintenance of youthful attitudes, cognitive and adaptational processes despite advanced age. Maintenance of homeostasis and efficient adaptational processes are of utmost importance. It is suggested that multiple hormonal systems and processes are involved in the multidimensi...

    journal_title：Psychoneuroendocrinology

    pub_type：

    doi：10.1016/s0306-4530(03)00130-6

    authors： Halbreich U

    更新日期：2004-07-01 00:00:00

  • Dipeptidyl peptidase- IV inhibitor alogliptin improves stress-induced insulin resistance and prothrombotic state in a murine model.

    abstract：BACKGROUND:Stress evokes lipolytic release of free fatty acid (FFA) and low-grade inflammation in visceral adipose tissue, mediated by increased adipokine secretion, and contributes to glucose metabolism disorder and prothrombotic state. We tested the hypothesis that alogliptin, a dipeptidyl peptidase-4 inhibitor, can ...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2016.08.004

    authors： Yisireyili M,Takeshita K,Hayashi M,Wu H,Uchida Y,Yamamoto K,Kikuchi R,Hao CN,Nakayama T,Cheng XW,Matsushita T,Nakamura S,Murohara T

    更新日期：2016-11-01 00:00:00

  • The effect of a low dose of alcohol on allopregnanolone serum concentrations across the menstrual cycle in women with severe premenstrual syndrome and controls.

    abstract：BACKGROUND:Neurosteroids have been proposed to play an important role in the interaction between alcohol and GABA(A) receptors and for the symptomatology of premenstrual dysphoric disorder (PMDD). The primary aim of this study was to investigate possible alcohol-induced changes in allopregnanolone serum concentrations ...

    journal_title：Psychoneuroendocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.psyneuen.2005.04.016

    authors： Nyberg S,Andersson A,Zingmark E,Wahlström G,Bäckström T,Sundström-Poromaa I

    更新日期：2005-10-01 00:00:00

  • Pain exposure associates with telomere length erosion in very preterm infants.

    abstract：:Very preterm (VPT) infants (gestational age < 32 weeks) require long-lasting hospitalization in the Neonatal Intensive Care Unit (NICU), even in absence of severe morbidities. During NICU stay, life-saving interventions occur and include invasive and painful skin-breaking procedures (NICU-related stress), which consti...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2018.01.009

    authors： Provenzi L,Giorda R,Fumagalli M,Pozzoli U,Morandi F,Scotto di Minico G,Mosca F,Borgatti R,Montirosso R

    更新日期：2018-03-01 00:00:00

  • Mental health and its associations with glucose-lowering medication in women with gestational diabetes mellitus. A prospective clinical cohort study.

    abstract：AIMS:Mental health symptoms are frequent in women with gestational diabetes mellitus (GDM) and may influence glycemic control. We therefore investigated if mental health symptoms (high depression and low well-being scores) predicted a need for glucose-lowering medication and if this use of medication influenced the tra...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2020.105095

    authors： Gilbert L,Nikolaou A,Quansah DY,Rossel JB,Horsch A,Puder JJ

    更新日期：2020-12-01 00:00:00

  • Chronic intermittent stress does not differentially alter brain corticosteroid receptor densities in rats prenatally exposed to ethanol.

    abstract：:Prenatal ethanol exposure produces hypothalamic-pituitary-adrenal (HPA) hyperresponsiveness to stressors. The present study tested the hypothesis that decreased corticosteroid receptor densities at HPA feedback sites may play a role in deficient feedback inhibition and the resultant HPA hyperresponsiveness that is obs...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/s0306-4530(99)00015-3

    authors： Kim CK,Yu W,Edin G,Ellis L,Osborn JA,Weinberg J

    更新日期：1999-08-01 00:00:00

  • Maternal cortisol output in pregnancy and newborn telomere length: Evidence for sex-specific effects.

    abstract：:Newborn telomere length is a potential biomarker of the effects of maternal-fetal processes on offspring long-term health. A number of maternal psychosocial and environmental factors in pregnancy (e.g., stress, health, socioeconomic status) have been associated with shortened telomere length at birth. The physiologica...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2018.12.222

    authors： Bosquet Enlow M,Sideridis G,Bollati V,Hoxha M,Hacker MR,Wright RJ

    更新日期：2019-04-01 00:00:00

  • Stress selectively and lastingly promotes learning of context-related high arousing information.

    abstract：:The secretion of adrenal stress hormones in response to acute stress is known to affect learning and memory, particularly for emotionally arousing memory material. Here, we investigated whether stress-induced modulation of learning and memory performance depends on (i) the conceptual relatedness between the material t...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2009.03.001

    authors： Smeets T,Wolf OT,Giesbrecht T,Sijstermans K,Telgen S,Joëls M

    更新日期：2009-09-01 00:00:00

  • The serum glucose response to acute stress is sensitive to the intensity of the stressor and to habituation.

    abstract：:The reliability of serum glucose concentrations as an index of habituation to chronic stress was evaluated in adult male rats. The glucose response to immobilization was attenuated by six days of previous chronic exposure to the same stressor, the degree of reduction being related to the duration (15 min, 1 hr or 4 hr...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/0306-4530(90)90059-i

    authors： Armario A,Marti J,Gil M

    更新日期：1990-01-01 00:00:00

  • Experienced discrimination and racial differences in leukocyte gene expression.

    abstract：:Racial disparities in health outcomes between African Americans and European Americans have been well-documented, but not fully understood. Chronic inflammation contributes to several of the diseases showing racial disparities (e.g., Human Immunodeficiency Virus [HIV]), and racial differences in stress exposure (e.g.,...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2019.04.016

    authors： Thames AD,Irwin MR,Breen EC,Cole SW

    更新日期：2019-08-01 00:00:00

  • The preliminary investigation of orexigenic hormone gene polymorphisms on posttraumatic stress disorder symptoms.

    abstract：:Orexigenic hormones are a group of hormones that can up-regulate appetite. Current studies have shown that orexigenic hormones also play important roles in stress responses and may be implicated in regulation of fear memory. However, these conclusions lack evidence from human studies. In this study, we examined associ...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2018.09.042

    authors： Li G,Zhang K,Wang L,Cao C,Fang R,Liu P,Luo S,Liberzon I

    更新日期：2019-02-01 00:00:00

  • Association between sleep duration and executive function differs between diabetic and non-diabetic middle-aged and older adults.

    abstract：:Executive function is defined as a set of cognitive skills that are necessary to plan, monitor, and execute a sequence of goal-directed complex actions. Executive function is influenced by a variety of factors, including habitual sleep duration and diabetes. In the present study, we investigated in 18,769 Swedish adul...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2019.104472

    authors： Titova OE,Lindberg E,Tan X,Elmståhl S,Lind L,Schiöth HB,Benedict C

    更新日期：2020-01-01 00:00:00

  • Effects of buprenorphine on responses to social stimuli in healthy adults.

    abstract：:In addition to its classical role in mediating responses to pain, the opioid system is strongly implicated in the regulation of social behavior. In young laboratory animals, low doses of opioid analgesic drugs reduce responses to isolation distress and increase play behavior. However, little is known about how opioid ...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2015.09.011

    authors： Bershad AK,Seiden JA,de Wit H

    更新日期：2016-01-01 00:00:00

  • Testosterone across successive competitions: evidence for a 'winner effect' in humans?

    abstract：:In many species testosterone fluctuates in concert with outcome-dependent changes in social status, such that winning a competition leads to an increase in circulating testosterone (i.e., competition effect). Although this phenomenon has been well studied in humans, the cumulative endocrine impact of multiple successi...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.psyneuen.2014.05.001

    authors： Zilioli S,Watson NV

    更新日期：2014-09-01 00:00:00

  • Use of an estradiol-based combined oral contraceptives has no influence on attentional bias or depressive symptoms in healthy women.

    abstract：:Combined oral contraceptive (COC) use is associated with small, albeit significant, increases in mental symptom scores, predominantly irritability, depressed mood, and anxiety. Yet, randomized prospective trials are needed to better characterize the women at risk for COC-induced negative mood change. Thus, the primary...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.psyneuen.2019.104544

    authors： Scheuringer A,Lundin C,Derntl B,Pletzer B,Sundström Poromaa I

    更新日期：2020-03-01 00:00:00

  • Oxytocin receptor gene polymorphisms exert a modulating effect on the onset age in patients with obsessive-compulsive disorder.

    abstract：:The oxytocin receptor (OXTR) is a potential candidate in the pathophysiology of obsessive-compulsive disorder (OCD). The present study investigated the association between common single-nucleotide polymorphism (SNPs) of the OXTR gene and the affected status of OCD or distinct clinical subtypes of OCD including the age...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2017.09.011

    authors： Kang JI,Kim HW,Kim CH,Hwang EH,Kim SJ

    更新日期：2017-12-01 00:00:00

  • Good stress, bad stress and oxidative stress: insights from anticipatory cortisol reactivity.

    abstract：:Chronic psychological stress appears to accelerate biological aging, and oxidative damage is an important potential mediator of this process. However, the mechanisms by which psychological stress promotes oxidative damage are poorly understood. This study investigates the theory that cortisol increases in response to ...

    journal_title：Psychoneuroendocrinology

    pub_type： 杂志文章

    doi：10.1016/j.psyneuen.2013.02.004

    authors： Aschbacher K,O'Donovan A,Wolkowitz OM,Dhabhar FS,Su Y,Epel E

    更新日期：2013-09-01 00:00:00