Abstract：
AIMS:Mental health symptoms are frequent in women with gestational diabetes mellitus (GDM) and may influence glycemic control. We therefore investigated if mental health symptoms (high depression and low well-being scores) predicted a need for glucose-lowering medication and if this use of medication influenced the trajectory of mental health during pregnancy and in the postpartum period. METHODS:We included 341 pregnant women from a cohort of GDM women in a Swiss University Hospital. The World Health Organization Well-being Index-Five was collected at the first and last GDM and at the postpartum clinical visits and the Edinburgh Postnatal Depression Scale at the first GDM and the postpartum clinical visits. Medication intake was extracted from participants' medical records. We conducted linear and logistic regressions with depression as an interaction factor. RESULTS:Mental health symptoms did not predict a need for medication (all p ≥ 0.29). Mental health improved over time (both p ≤ 0.001) and use of medication did not predict this change (all p ≥ 0.40). In women with symptoms of depression, medication was associated with less improvement in well-being at the postpartum clinical visit (p for interaction=0.013). CONCLUSIONS:Mental health and glucose-lowering medication did not influence each other in an unfavourable way in this cohort of women with GDM.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Gilbert L,Nikolaou A,Quansah DY,Rossel JB,Horsch A,Puder JJdoi
10.1016/j.psyneuen.2020.105095subject
Has Abstractpub_date
2020-12-01 00:00:00pages
105095eissn
0306-4530issn
1873-3360pii
S0306-4530(20)30518-7journal_volume
124pub_type
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