Abstract：
BACKGROUND:Autism is a severe neurodevelopmental disorder characterized by impairment in communication, social interaction, repetitive behaviors and difficulty adapting to novel experiences. The Hypothalamic-Pituitary-Adrenocortical (HPA) system responds consistently to perceived novel or unfamiliar situations and can serve as an important biomarker of the response to a variety of different stimuli. Previous research has suggested that children with autism may exhibit dysfunction of the HPA system, but it is not clear whether altered neuroendrocrine regulation or altered responsiveness underlies the differences between children with and without autism. In order to provide preliminary data concerning HPA regulation and responsiveness, we compared circadian rhythms and response to a non-social, environmental stressor in children with and without autism. METHODS:Circadian rhythms of cortisol were estimated in children with (N=12) and without (N=10) autism via analysis of salivary samples collected in the morning, afternoon and evening on 2 consecutive days. HPA responsiveness was assessed by examining the time course of changes in salivary cortisol in response to a mock MRI. RESULTS:Both groups showed expected circadian variation with higher cortisol concentration in morning than in the evening samples. The children with autism, but not typical children, showed a more variable circadian rhythm as well as statistically significant elevations in cortisol following exposure to a novel, nonsocial stimulus. CONCLUSIONS:The results suggest that children with autism process and respond idiosyncratically to novel and threatening events resulting in an exaggerated cortisol response.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Corbett BA,Mendoza S,Abdullah M,Wegelin JA,Levine Sdoi
10.1016/j.psyneuen.2005.05.011keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
59-68issue
1eissn
0306-4530issn
1873-3360pii
S0306-4530(05)00127-7journal_volume
31pub_type
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
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abstract：PURPOSE:The aim of the present study was to investigate the differences in the topological organization of functional brain networks between children with growth hormone deficiency (GHD) and those with idiopathic short stature (ISS). METHODS:Thirty-one children with GHD and fifty-three children with ISS were recruited...
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pub_type： 杂志文章,随机对照试验
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2007.05.001
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,评审
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更新日期：1983-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/s0306-4530(98)00044-4
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journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2015.08.011
更新日期：2015-12-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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更新日期：2008-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2015.09.011
更新日期：2016-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-06-01 00:00:00
abstract：:Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis influences the risk for developing stress-related disorders. Sex-dependent differences in the HPA axis stress response are believed to contribute to the different prevalence rates of stress-related disorders found in men and women. However, studies examini...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2015.12.021
更新日期：2016-04-01 00:00:00
abstract：CONTEXT:A wide variety in hydrocortisone (HC) substitution dose-regimens are considered physiological for patients with secondary adrenal insufficiency (SAI). However, it is likely that cognition is negatively influenced by higher cortisol exposure to the brain. OBJECTIVE:To examine the effects of a high physiological...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psyneuen.2015.02.001
更新日期：2015-05-01 00:00:00
