Abstract：
:A comparison of the effect on growth hormone (GH) stimulation in men (n = 6) of desimipramine (DMI), a tricyclic antidepressant, and of the benzodiazepine derivatives diazepam and metaclazepam with that of a placebo, showed that only DMI caused a significant (p less than 0.01) GH stimulation. After DMI, all six subjects showed a GH stimulation greater than 7.5 ng/ml, whereas after diazepam or metaclazepam, only three of the six subjects showed GH stimulation greater than 7.5 ng/ml, and the other three showed only a very small change, or no change at all in GH secretion. Higher GH stimulation occurred after diazepam (10 mg i.v.) than after diazepam (10 mg p.o.). No dose-dependent difference in GH stimulation after metaclazepam (10 and 30 mg p.o.) was apparent. No side effects appeared after administration of DMI during the test period (180 min); however, after administration of the benzodiazepine derivatives, sedative effects were clearly noted. DMI thus causes reliable GH stimulation in healthy male subjects, whereas GH stimulation could only be measured in some of the subjects after diazepam and metaclazepam.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Laakmann G,Treusch J,Schmauss M,Schmitt E,Treusch Udoi
10.1016/0306-4530(82)90006-3subject
Has Abstractpub_date
1982-01-01 00:00:00pages
141-6issue
2-3eissn
0306-4530issn
1873-3360pii
0306-4530(82)90006-3journal_volume
7pub_type
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