Abstract：
:There is now an expanding volume of evidence to support the view that commensal organisms within the gut play a role in early programming and later responsivity of the stress system. The gut is inhabited by 10¹³-10¹⁴ micro-organisms, which is ten times the number of cells in the human body and contains 150 times as many genes as our genome. It has long been recognised that gut pathogens such as Escherichia coli, if they enter the gut can activate the HPA. However, animals raised in a germ-free environment show exaggerated HPA responses to psychological stress, which normalises with monocolonisation by certain bacterial species including Bifidobacterium infantis. Moreover, increased evidence suggests that animals treated with probiotics have a blunted HPA response. Stress induces increased permeability of the gut allowing bacteria and bacterial antigens to cross the epithelial barrier and activate a mucosal immune response, which in turn alters the composition of the microbiome and leads to enhanced HPA drive. Increasing data from patients with irritable bowel syndrome and major depression indicate that in these syndromes alteration of the HPA may be induced by increased gut permeability. In the case of irritable bowel syndrome the increased permeability can respond to probiotic therapy. Detailed prospective studies in patients with mood disorders examining the gut microbiota, immune parameters and HPA activity are required to throw further light on this emerging area. It is however clear that the gut microbiota must be taken into account when considering the factors regulating the HPA.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Dinan TG,Cryan JFdoi
10.1016/j.psyneuen.2012.03.007subject
Has Abstractpub_date
2012-09-01 00:00:00pages
1369-78issue
9eissn
0306-4530issn
1873-3360pii
S0306-4530(12)00093-5journal_volume
37pub_type
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,随机对照试验
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更新日期：2019-04-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1986-01-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2004-07-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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更新日期：2011-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2010-08-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
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更新日期：2011-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2017.11.004
更新日期：2018-02-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2014-06-01 00:00:00
