Abstract：
OBJECTIVE:Brain-derived neurotrophic factor (BDNF) supports neurogenesis, angiogenesis, and promotes the survival of various cell types in the brain and the coronary system. Moreover, BDNF is associated with both coronary heart disease (CHD) and depression. The current study aims to investigate whether serum BDNF levels are associated with the course of depressive symptoms in CHD patients. METHODS:At baseline, N=225 CHD patients were enrolled while hospitalized. Of these, N=190 (84%) could be followed up 6 months later. Depressive symptoms were assessed both at baseline and at the 6-months follow-up using the Patient Health Questionnaire (PHQ-9). Serum BDNF concentrations were measured using fluorometric Enzyme-linked immunosorbent assays (ELISA). RESULTS:Logistic regression models showed that lower BDNF levels were associated with persistent depressive symptoms, even after adjustment for age, sex, smoking and potential medical confounders. The incidence of depressive symptoms was not related to lower BDNF levels. However, somatic comorbidity (as measured by the Charlson Comorbidity Index) was significantly associated with the incidence of depressive symptoms. CONCLUSIONS:Our findings suggest a role of BDNF in the link between CHD and depressive symptoms. Particularly, low serum BDNF levels could be considered as a valuable biomarker for the persistence of depressive symptoms among depressed CHD patients.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Kuhlmann SL,Tschorn M,Arolt V,Beer K,Brandt J,Grosse L,Haverkamp W,Müller-Nordhorn J,Rieckmann N,Waltenberger J,Warnke K,Hellweg R,Ströhle Adoi
10.1016/j.psyneuen.2016.12.015subject
Has Abstractpub_date
2017-03-01 00:00:00pages
196-202eissn
0306-4530issn
1873-3360pii
S0306-4530(16)30712-0journal_volume
77pub_type
杂志文章abstract：:Recent breakthroughs in cannabinoid research, including the identification of two cannabinoid receptors (CB receptors) and a family of endogenous ligands, the anandamides, may shed new light on the sequelae of pre- and perinatal exposure to cannabinoid receptor ligands and enable the experimental manipulation of the e...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(95)00039-9
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abstract：:Antidepressants affect glucocorticoid receptor (GR) functioning partly through modulation of its phosphorylation but their effects on mitochondrial GR have remained undefined. We investigated the ability of chronic fluoxetine treatment to affect chronic stress-induced changes of mitochondrial GR and its phosphoisoform...
journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2013.07.019
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
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abstract：:Inflammation, which may be present in a subgroup of individuals with major depressive disorder (MDD), activates the kynurenine metabolic pathway to produce kynurenine metabolites kynurenic acid (KynA) and quinolinic acid (QA). We have previously reported an association between the ratio of KynA to QA and hippocampal v...
journal_title：Psychoneuroendocrinology
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pub_type： 杂志文章
doi：10.1016/0306-4530(87)90019-9
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
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abstract：:The peptide hormone oxytocin (OT) plays an important role in social behaviors, including social bond formation. In different contexts, however, OT is also associated with aggression, social selectivity, and reduced affiliation. Female meadow voles form social preferences for familiar same-sex peers under short, winter...
journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
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更新日期：1989-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(94)90057-4
更新日期：1994-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2010.02.006
更新日期：2010-09-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(90)90033-6
更新日期：1990-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1016/j.psyneuen.2009.07.006
更新日期：2010-04-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
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更新日期：2012-08-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,评审
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pub_type： 杂志文章,随机对照试验
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
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journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章,随机对照试验
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更新日期：2010-11-01 00:00:00
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journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
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更新日期：1985-01-01 00:00:00
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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更新日期：2020-02-01 00:00:00
