Abstract：
BACKGROUND:The crucial role of the hypothalamic-pituitary-adrenal axis (HPA) in stress-related homeostasis suggests dysregulated HPA involvement in the pathogenesis of post-traumatic stress disorder (PTSD), yet most studies examining linkages between HPA axis measures and PTSD have yielded null findings. One untested explanation for this inconsistency is a failure to account for simultaneous adrenal and gonadal influence. Here we tested the singular and interactive effects of cortisol (CR) and testosterone (TR) reactivity as moderators of war-zone stress evoked PTSD emergence in the war-zone. METHODS:U.S. soldiers (N=120) scheduled for deployment to Iraq completed pre-deployment measures of CR and TR stress reactivity to a CO2 inhalation challenge. Once deployed, monthly assessments of exposure to traumatic war-zone stressors and PTSD symptoms were collected via a web-based assessment system. RESULTS:Cortisol hypo-reactivity potentiated the pathogenic impact of war-zone stressors only in soldiers for whom the CO2 challenge did not elevate testosterone, suggesting that the dual hormone stress reactivity profile of blunted cortisol and testosterone may confer increased risk for PTSD emergence by potentiating the pathogenic effects of war-zone stressors. CONCLUSIONS:Findings underscore the utility of assessing both HPA and HPG stress reactivity when assessing PTSD vulnerability and may help inform efforts for enhanced soldier screening and inoculation to war-zone stressors.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Josephs RA,Cobb AR,Lancaster CL,Lee HJ,Telch MJdoi
10.1016/j.psyneuen.2017.01.013subject
Has Abstractpub_date
2017-04-01 00:00:00pages
76-84eissn
0306-4530issn
1873-3360pii
S0306-4530(16)30676-Xjournal_volume
78pub_type
杂志文章abstract：:Spouses share common risks for cardiometabolic diseases: a person's diabetes or hypertension raises the partner's odds of developing the same condition. The mechanisms responsible for this disease concordance remain poorly understood. To examine three factors that may modulate partners' cardiometabolic similarity-clos...
journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/0306-4530(95)00005-9
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journal_title：Psychoneuroendocrinology
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doi：10.1016/j.psyneuen.2009.01.018
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journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
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journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 杂志文章
doi：10.1016/j.psyneuen.2014.06.011
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pub_type： 杂志文章
doi：10.1016/j.psyneuen.2016.12.015
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pub_type： 杂志文章,随机对照试验
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更新日期：2011-09-01 00:00:00
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pub_type： 临床试验,杂志文章
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journal_title：Psychoneuroendocrinology
pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,评审
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journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
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journal_title：Psychoneuroendocrinology
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