Abstract:
:Binge eating is a behavior observed in a variety of human eating disorders. Ad libitum fed rodents daily and time-limited exposed to a high-fat diet (HFD) display robust binge eating events that gradually escalate over the initial accesses. Intake escalation is proposed to be part of the transition from a controlled to a compulsive or loss of control behavior. Here, we used a combination of behavioral and neuroanatomical studies in mice daily and time-limited exposed to HFD to determine the neuronal brain targets that are activated--as indicated by the marker of cellular activation c-Fos--under these circumstances. Also, we used pharmacologically or genetically manipulated mice to study the role of orexin or ghrelin signaling, respectively, in the modulation of this behavior. We found that four daily and time-limited accesses to HFD induce: (i) a robust hyperphagia with an escalating profile, (ii) an activation of different sub-populations of the ventral tegmental area dopamine neurons and accumbens neurons that is, in general, more pronounced than the activation observed after a single HFD consumption event, and (iii) an activation of the hypothalamic orexin neurons, although orexin signaling blockage fails to affect escalation of HFD intake. In addition, we found that ghrelin receptor-deficient mice fail to both escalate the HFD consumption over the successive days of exposure and fully induce activation of the mesolimbic pathway in response to HFD consumption. Current data suggest that the escalation in high fat intake during repeated accesses differentially engages dopamine neurons of the ventral tegmental area and requires ghrelin signaling.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Valdivia S,Cornejo MP,Reynaldo M,De Francesco PN,Perello Mdoi
10.1016/j.psyneuen.2015.06.018subject
Has Abstractpub_date
2015-10-01 00:00:00pages
206-16eissn
0306-4530issn
1873-3360pii
S0306-4530(15)00233-4journal_volume
60pub_type
杂志文章abstract::It has been proposed that aging occurs because of a failure of the pineal gland to produce melatonin from serotonin each day beginning at sunset and throughout the night. This lack leads to a nighttime deficiency of melatonin both absolutely and also relatively to serotonin. As melatonin has wide-spread integrative an...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/0306-4530(93)90025-g
更新日期:1993-01-01 00:00:00
abstract::In laboratory studies of individual differences in stress reactivity, cortisol responses are typically measured by comparing a prestress baseline with values obtained at the end of the stressor. In the present study, we measured cortisol in this manner on a stress day, but we also took samples on a second day when the...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2010.02.015
更新日期:2010-09-01 00:00:00
abstract::Chronic stress contributes to many neuropsychiatric disorders in which the HPA axis, cognition and neuro-immune activity are dysregulated. Patients with major depression, or healthy individuals subjected to acute stress, present elevated levels of circulating pro-inflammatory markers. Acute stress also activates pro-i...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2011.02.008
更新日期:2011-09-01 00:00:00
abstract::The translocator protein 18 kDa (TSPO), initially characterized as peripheral benzodiazepine receptor, is a conserved outer mitochondrial membrane protein, implicated in cholesterol transport thereby affecting steroid hormone biosynthesis, as well as in general mitochondrial function related to bioenergetics, oxidativ...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.03.029
更新日期:2019-08-01 00:00:00
abstract::Allergic rhinitis (AR) is the fifth most common chronic disease, and the association between allergic disorders and anxiety is well-documented. To investigate how anxiety and stressors modulate skin prick test (SPT) responses and associated inflammatory responses, 28 men and women with AR were selected by clinical his...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2008.11.010
更新日期:2009-06-01 00:00:00
abstract::Testosterone concentrations rise rapidly in the context of competitive interactions and remain elevated in winners relative to losers. Theoretical models suggest that this divergent neuroendocrine response serves to mediate future dominance behaviours. Although research in animal models provides compelling support for...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2013.03.008
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Hypothalamus-Pituitary-Adrenal (HPA) axis dysregulation is often seen in major depression, and is thought to represent a trait vulnerability - rather than merely an illness marker - for depressive disorder and possibly anxiety disorder. Vulnerability traits associated with stress-related disorders might refl...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2010.07.014
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:The aim of the present study was to investigate the differences in the topological organization of functional brain networks between children with growth hormone deficiency (GHD) and those with idiopathic short stature (ISS). METHODS:Thirty-one children with GHD and fifty-three children with ISS were recruited...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2018.12.229
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Lack of social support and social exclusion are associated with adverse effects for mental and physical health. Additionally, women appear to be more vulnerable to social triggers of health disturbances. Activity of the hypothalamus-pituitary-adrenal-axis (HPA-axis) might play a key role in this context as i...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2010.02.019
更新日期:2010-10-01 00:00:00
abstract::We have previously shown that serum gonadotropins, particularly LH, decline after acute exercise in male volunteers. The mechanism for this decline is unknown. Plasma leptin and IGF-I concentrations were measured in seven male volunteers after acute exercise to exhaustion using the Bruce protocol. Leptin concentration...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/s0306-4530(99)00070-0
更新日期:2000-07-01 00:00:00
abstract::Male and female rats were segregated from birth (sexually isolated animals). Additional litters containing both male and female pups were kept as controls (mixed-housed animals). beta-FNA (5 mg/kg) or water was administered SC at day 0 or day 7 to isolated and mixed-housed animals. The development of mu-opioid recepto...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(93)90016-e
更新日期:1993-01-01 00:00:00
abstract::The effects on retrieval of a one-trial learning inhibitory avoidance response of beta-endorphin, alpha-endorphin, and gamma-endorphin, given prior to test have been studied in rats. beta-Endorphin (beta-LPH 61-91) in a relatively low dose (1.56 micrograms sc. or 50 ng icv.) facilitated inhibitory avoidance behavior, ...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(83)90020-3
更新日期:1983-01-01 00:00:00
abstract::It is suggested that the symptoms of anorexia nervosa are physiological responses to starvation. There is no evidence of a neural or non-neural dysfunction that predisposes women for anorexia nervosa and the endocrine and psychological consequences of starvation are reversed once patients have re-learnt how to eat and...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.psyneuen.2006.09.006
更新日期:2006-11-01 00:00:00
abstract::The prolactin (PRL) and cortisol responses to oral D-fenfluramine (30 mg) and placebo were measured in seven healthy subjects (two women and five men) in the morning and in the afternoon. As compared to placebo, D-fenfluramine significantly increased plasma PRL levels in both the morning and the afternoon, with no sig...
journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0306-4530(96)00041-8
更新日期:1997-02-01 00:00:00
abstract::The acute phase response to infection is reliably accompanied by decreases in social investigation; however, social behavior is commonly assayed in inescapable environments using unfamiliar social stimuli. In this experiment, male Wistar rats were raised from weaning with 2 familiar, same-sex conspecifics. In adulthoo...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2011.11.008
更新日期:2012-07-01 00:00:00
abstract::This study aimed to examine how loneliness contributes to metabolic dysregulation among older adults with depression and determine the relative contribution of loneliness to the development of chronic diseases in late adulthood. Harmonised data from the Ageing Trajectories of Health: Longitudinal Opportunities and Syn...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2020.104918
更新日期:2021-01-01 00:00:00
abstract::Recent studies indicate the presence of adenosine binding sites in rat pinealocytes and an effect of their activation on pineal serotonin metabolism. However, controversial data exist, and reports suggest that the role of adenosine in pineal physiology is complex. On this basis, we evaluated the effects of an adenosin...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(92)90064-e
更新日期:1992-05-01 00:00:00
abstract::Brain oxytocin (OXT) plays an important role in short-term social memory in laboratory rodents. Here we monitored local release of OXT and its functional involvement in the maintenance and retrieval of social memory during the social discrimination test. We further assessed, if the local effects of OXT within the medi...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2012.09.018
更新日期:2013-06-01 00:00:00
abstract::Exposure to acute psychosocial stress has been shown to affect moral decision-making, though little is known about potential gender differences or effects of personality. In two within-subjects design studies, 179 healthy men and women (N = 99 in Study 1, N = 80 in Study 2) were exposed to the Trier Social Stress Test...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2020.105084
更新日期:2020-12-01 00:00:00
abstract::Sensitization is defined as a non-associative learning process occurring when repeated administrations of a stimulus result in a progressive amplification of a response (Shettleworth, 2010). The purpose of this review paper is to discuss whether brain sensitization is helpful in common health problems in man. The pape...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.psyneuen.2014.01.008
更新日期:2014-04-01 00:00:00
abstract::Significant emotional and physical symptoms have been linked to hormonal changes during the menstrual cycle. A critical evaluation of the available studies questions the commonly held belief in menstrual-cycle-related complaints in the majority of normal women. The present study investigated changes in mood, somatic c...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(90)90021-z
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Leptin (LEP) is a hormone central for energy homeostasis and has been implicated in neurodevelopment. This adipokine is produced by the placenta and is epigenetically regulated by promoter DNA methylation. Recent evidence has suggested a role for LEP in behavioral development. In this study, we investigated ...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2013.10.012
更新日期:2014-02-01 00:00:00
abstract::The cortisol rise after awakening (CAR) is a frequently applied measure of pituitary-adrenal activity. This measure seems to reflect the acrophase of the diurnal cycle and can easily be assessed in saliva samples, collected by the proband or patient under real life conditions. Since different state and trait factors a...
journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
doi:10.1016/j.psyneuen.2006.10.005
更新日期:2007-01-01 00:00:00
abstract::Latina mothers, who have the highest fertility rate among all ethnic groups in the US, are often exposed to discrimination. The epigenetic changes related to this discrimination are largely unknown. This study is the first to explore the relationship between discrimination and DNA methylation of stress regulatory gene...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2018.08.014
更新日期:2018-12-01 00:00:00
abstract::Prenatal maternal stress (PNMS) predicts psychosocial development in offspring. It has been hypothesized that during PNMS, glucocorticoids pass the placenta, reaching the foetus, leading to a long-term reprogramming and dysregulation of the foetal hypothalamic-pituitary-adrenal (HPA) axis. However, results are inconsi...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2015.02.015
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Flibanserin, a novel serotonin (5-HT)(1A) agonist and 5-HT(2A) antagonist, has been shown to increase sexual desire and reduce distress in women with Hypoactive Sexual Desire Disorder (HSDD). In marmoset monkeys, flibanserin has demonstrated pro-social effects on male-female pairmates, while the classic 5-HT...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2012.05.011
更新日期:2013-01-01 00:00:00
abstract::Since hypnosis was popularly recognized in the nineteenth century, the phenomenon of hypnotizability has remained poorly understood. The capacity to increase hypnotizability has important implications because it may increase the number of people who can benefit from hypnotic interventions for psychological and medical...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2011.05.010
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Disturbances in the hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-adrenal (HPA) axes have been frequently found in major depression. Given that glucocorticoids may inhibit thyrotropin (TSH) and thyrotropin-releasing hormone (TRH) secretion, it has been hypothesized that hypercortisolemia co...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2020.104831
更新日期:2020-12-01 00:00:00
abstract:CONTEXT:The rise of cortisol concentrations after awakening is well documented in adults and children and commonly used as easily accessible marker of hypothalamic-pituitary-adrenal (HPA) reactivity. OBJECTIVE:The purpose of this study was to demonstrate the existence of a salivary cortisol awakening response (CAR) in...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2012.08.002
更新日期:2013-05-01 00:00:00
abstract::Stress disorders are among the most commonly occurring of all mental disorders. In this context, the question arises whether the stress inevitably unfolding around us has the potential to "contaminate" and compromise us. In the current multi-center study, we investigate the existence of such empathic stress (defined a...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.psyneuen.2014.04.005
更新日期:2014-07-01 00:00:00