Abstract：
BACKGROUND:The present study reported a six-year follow up of patients with chronic myeloid leukemia who were on imatinib therapy. METHODS:We performed a retrospective study on a total of 417 patients diagnosed with chronic-phase, Philadelphia-positive (Ph+) chronic myeloid leukemia within six months before study entry. Patients were eligible for the study if they were between 18 and 70 years of age. Enrolled patients were treated at an initial dose of 400 mg of imatinib. RESULTS:The mean age of 417 patients was 40.9±14.5 years; 220 (52%) were men and 197 (47.2%) were women. Complete hematologic response at three months occurred in 99% of patients, 221 (53%) before four weeks and 196 (47%) after four weeks. Adverse events occurred in 17 (4.1%) of patients, relapse in 46 (11%) and death in 31 (7.4%) of our studied population. At 72 months, the estimated rate of overall survival rate was 89%. DISCUSSION:Our findings showed the efficacy and safety of imatinib mesylate among Iranian patients with chronic myeloid leukemia by hematological and molecular response.
journal_name
Arch Iran Medjournal_title
Archives of Iranian medicineauthors
Jalaeikhoo H,Ahmadzadeh A,Toogeh G,Haybar H,Valizadeh A,Charoosaei R,Yadollahzadeh M,Keyhani Mdoi
011146/AIM.004subject
Has Abstractpub_date
2011-11-01 00:00:00pages
378-80issue
6eissn
1029-2977issn
1735-3947pii
004journal_volume
14pub_type
杂志文章abstract：:Infection-associated hemophagocytic syndrome is a life-threatening condition characterized by prolonged fever, hepatosplenomegaly, and cytopenia-most commonly, thrombocytopenia and anemia. It is characterized by proliferation and activation of benign histiocytes, causing dysfunction of various organs. Herein, we repor...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND:HIV infection affects all body organs including kidney. Since the frequency of HIV-related renal disorders is unknown in Iran and the number of HIV-infected patients is increasing, this study was conducted for the first time in Iran to assess the frequency of electrolyte imbalance, renal failure, and protein...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：07103/AIM.0010
更新日期：2007-07-01 00:00:00
abstract：BACKGROUND:Recent evidence has indicated that polyunsaturated fatty acids (PUFA), such as omega-3 PUFA, have protective effects on a range of chronic inflammatory conditions, including obesity, and may play a role in the reversal of steatohepatitis. However, the effects of omega-3 PUFA on adipokine expression and hepat...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：014178/AIM.008
更新日期：2014-08-01 00:00:00
abstract：:As there is a significant number of Iranian immigrant and illegal refugees living in marginal areas of large cities that might induce immunization gap in these areas. The aim of this study was to provide reliable information on vaccination status of these people. A cross sectional study was conducted on children 24-4...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0141710/AIM.0011
更新日期：2014-10-01 00:00:00
abstract：INTRODUCTION:Recent advances in pharmacy practice have created serious ethical challenges for the pharmacists. Pursuing a new philosophy of practice is required to overcome these challenges and optimize the standard of care. In this regard, the current ethics guideline in the Pharmacy curriculum used in Tehran Universi...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0172001/AIM.009
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:Successful isolation of mesenchymal stem cells from waste tissues might be extremely promising for developing stem cell-based therapies. This study aimed to explore whether cells retrieved from teeth extracted due to advanced periodontal disease present mesenchymal stem cell-like properties. METHODS:Pulp ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：015184/AIM.004
更新日期：2015-04-01 00:00:00
abstract：:Evans syndrome is a rare syndrome associated with the simultaneous or sequential development of autoimmune hemolytic anemia (AIHA) and idiopathic thrombocytopenic purpura (ITP). Furthermore, acute kidney injury (AKI) is a syndrome characterized by the rapid loss of kidney excretory function and is most often secondary...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2019-06-01 00:00:00
abstract：:Hereditary spherocytosis (HS), a familial defect involving red blood cell (RBC) membrane proteins, is associated with reduced deformability, increased fragility, and progressive destruction of spherical cells. The present study focuses on three subjects of a family showing a history of repeated episodes of lethargy an...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2020-03-01 00:00:00
abstract：:Primitive neuroectodermal tumors (PNETs) are a family of highly malignant soft tissue neoplasms mostly occurring in children and young adults. PNETs usually develop in the thoracopulmonary region, abdomen, pelvis, and rarely in the head and neck region. Here, a case of PNET located in the parotid gland is reported. ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0151812/AIM.0012
更新日期：2015-12-01 00:00:00
abstract：:Heterotopic neuroglial tissue, composed of differentiated neuroectodermal tissue, represents developmental heterotopia of neuroglial tissue rather than true neoplasm. Herein, we present a patient with nasopharyngeal heterotopic neuroglial tissue who presented with respiratory distress and feeding difficulty in early d...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND:There is a lack of data regarding the incidence rate, etiology, risk factors, and natural course of thyroid disorders and their relationship with cardiovascular disease and mortality in populations undergoing nutrition transition. Therefore, we aimed to assess the natural course of thyroid disease in Tehrani...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：013167/AIM.0011
更新日期：2013-07-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：08111/AIM.009
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:In the present study, the effect of dextromethorphan on antinociception and tolerance induced by water swim-stress in the formalin test was investigated. METHODS:Swim-stress at 8 masculineC induces antinociception in both phases of the formalin test. Intraperitoneal administration of dextromethorphan (60 mg...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：08113/AIM.0010
更新日期：2008-05-01 00:00:00
abstract：: Intellectual Disability (ID, also known as mental retardation) is a debilitating neurodevelopmental disorder affecting nearly 1% of the general population worldwide. Occurrence of behavioral disorders in individuals with ID is four times higher than that in the general population. An increasing number of studies seek...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章,评审
doi：0161905/AIM.0012
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Advanced computed tomography (CT) scanners enable concurrent assessment of coronary artery anatomy and myocardial perfusion. The purpose of this study was to assess dual-energy CT images in a group of patients suspected for ischemic heart disease and to evaluate agreement of cardiac computed tomography perfu...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:Our aim was to determine the association between age at menarche (AAM) and breast cancer adjusted for recall bias (misclassification) in AAM. METHODS:We have used data provided from a case-control study conducted in Iran from 2005 to 2009. The cases and controls were frequency matched based on 5-year age gr...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Non-antifungal drugs appear promising in treatment of opportunistic infections of Candida spp. that are often resistant to current antifungals. METHODS:The broth macrodilution method (NCCLS M27-P document) was used to compare the antifungal activity of trifluoperazine, propranolol, and lansoprazole with tha...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：012151/AIM.009
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:The use of endoscopic surgery for nasal and sinus pathologies has revolutionized our approaches towards the diseases of these areas. OBJECTIVE:To report our experience with endoscopic surgery of benign tumors and tumor-like conditions of the nose and paranasal sinuses. METHODS:The medical records of 105 pa...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND:This study ascertained the effects of soy, in the forms of textured soy protein (TSP) and soy nuts, on lipid profiles, apolipoproteins, inflammatory and prothrombotic markers, and blood pressure in elderly women diagnosed with metabolic syndrome (MetS). METHODS:This was a 12-week parallel, randomized, contr...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章,随机对照试验
doi：012158/AIM.004
更新日期：2012-08-01 00:00:00
abstract：PURPOSE:To evaluate the outcome of laparoendoscopic single-site (LESS-A) through one transumbilical port vs. 3-port laparoscopic (3TA) appendectomy in children. METHODS:We reviewed the records of 309 children (65 LESS-A, 244 3TA) operated on between 2008 and 2012. One hundered forty-nine patients had acute catarrhalis...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0161901/AIM.0011
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Thalassemia major and its treatment by stem cell transplantation can have deleterious effects on bone integrity. This study assesses the adverse effects of transplantation on growing bones of pediatric thalassemic patients. METHODS:Bone mineral density (BMD) of 20 patients from three thalassemia classes who...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：013162/AIM.008
更新日期：2013-02-01 00:00:00
abstract：:Esophageal cancer (EC) is the 8th most common cancer and the 6th most frequent cause of cancer mortality worldwide. Esophageal squamous cell carcinoma (ESCC) is the most common type of EC. Exposure to polycyclic aromatic hydrocarbons (PAHs) has been suggested as a risk factor for developing ESCC. In this paper we will...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章,评审
doi：0121511/AIM.0013
更新日期：2012-11-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0141703/AIM.007
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Pancreatic cancer is the fourth most common cause of mortality due to cancer, globally. It has a poor prognosis and is usually diagnosed at later stages when tumor resection is not possible. Heritability for pancreatic cancer is relatively high and clinically significant. METHODS:A group of 24 pancreatic ca...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Dementia is a disabling syndrome, which generally affects aged population more than any other age groups. This syndrome has a growing prevalence and incidence worldwide. The prevalence and burden of this group of diseases in Iran have not been estimated in a community-based study yet. This paper aims to expl...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0141712/AIM.007
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:There is controversial data available regarding the impact of age at menarche on cardio-metabolic parameters. This community-based study aimed to assess this association among Iranian women. METHODS:We recruited 5,344 eligible women out of 7718, aged 10-50 years who participated in the Tehran lipid and gluc...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2019-09-01 00:00:00
abstract：:Chronic ulcers of the oral mucosa are the lesions which a physician comes across frequently. "Eosinophilic Ulcer" is a rare variety of that. Eosinophilic ulcer or traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a chronic benign lesion of the oral mucosa and is a relatively recent delineated entity....
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0141701/AIM.0015
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Functional foods are extensively studied for their cancer preventive effects. In the present study, we compared the anti-cancer activity of aqueous extracts of three species of mushrooms including: Pleurotus ostreatus (PAE), Auricularia polytricha (AAE) and Macrolepiota procera (MAE) on COLO-205 cells. METH...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0151805/AIM.006
更新日期：2015-05-01 00:00:00
abstract：:Several studies have shown that patients with acromegaly are at increased risk of developing colorectal polyps and cancer. The prevalence of polyp in colon of patients with acromegaly was variously reported between 23% and 53%. This study was conducted to determine the prevalence of polyp and cancer of colon in patien...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：07102/AIM.0019
更新日期：2007-04-01 00:00:00
abstract：:Adrenal cysts are rare lesions which are usually nonfunctional and asymptomatic. Adrenal pseudocysts do not have epithelial linings and account for about 40% of adrenal cysts. We report a case of giant adrenal pseudocyst in a 32 year old woman presenting with flank pain who had undergone surgical excision. ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0131612/AIM.0012
更新日期：2013-12-01 00:00:00
