Abstract：
BACKGROUND:Pancreatic cancer is the fourth most common cause of mortality due to cancer, globally. It has a poor prognosis and is usually diagnosed at later stages when tumor resection is not possible. Heritability for pancreatic cancer is relatively high and clinically significant. METHODS:A group of 24 pancreatic cancer patients with young age at onset, from a referral hospital in Tehran University of Medical Sciences were screened for mutations in 710 cancer relevant genes using next generation sequencing technology. RESULTS:Two patients had pathogenic mutations in known pancreatic cancer susceptibility genes, BRCA1/2. Two other patients also had potentially pathogenic mutations in 2 novel candidate genes including PARP4 and EXO1. CONCLUSION:BRCA1/2 genes are the most commonly mutated pancreatic cancer susceptibility genes that should be considered in all pancreatic cancer cases with young age at onset or a family history of cancer. PARP4 and EXO1 also are potential candidate genes for susceptibility to pancreatic cancer. Identifying the hereditary cases of pancreatic cancer will help to offer more targeted treatments to the patients and also to prevent cancer in family members who might be a mutation carrier.
journal_name
Arch Iran Medjournal_title
Archives of Iranian medicineauthors
Alimirzaie S,Mohamadkhani A,Masoudi S,Sellars E,Boffetta P,Malekzadeh R,Akbari MR,Pourshams Asubject
Has Abstractpub_date
2018-06-01 00:00:00pages
228-233issue
6eissn
1029-2977issn
1735-3947pii
S1029-2977-21(06)228-0journal_volume
21pub_type
杂志文章abstract：BACKGROUND:Preventing violence is important especially in the Middle East, where many countries are struggling with violence. Knowing the affecting factors could help public policy makers to decrease violence level. Thus, this study is aimed to analyze health and other socio-economic factors that could affect interpers...
journal_title：Archives of Iranian medicine
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doi：
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Because resistance to antifungal drugs is seen in patients, susceptibility testing of these drugs aids in choosing the appropriate drug and respective epidemiology. This study has investigated and compared susceptibility patterns of the Aspergillus species isolated from patients by the Clinical and Laborator...
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更新日期：2012-07-01 00:00:00
abstract：:On January 23, 2020, the Chinese government announced the city lockdown of Wuhan. Since then, there have been controversial debates among experts about the efficacy of mass quarantine, the oldest and probably one of the most effective methods for controlling infectious disease outbreaks. The impact of health policymak...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章,评审
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journal_title：Archives of Iranian medicine
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journal_title：Archives of Iranian medicine
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更新日期：2015-12-01 00:00:00
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journal_title：Archives of Iranian medicine
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更新日期：2009-09-01 00:00:00
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journal_title：Archives of Iranian medicine
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doi：
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2006-04-01 00:00:00
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journal_title：Archives of Iranian medicine
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doi：
更新日期：2006-10-01 00:00:00
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journal_title：Archives of Iranian medicine
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doi：0151810/AIM.008
更新日期：2015-10-01 00:00:00
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pub_type： 历史文章,杂志文章
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更新日期：2011-11-01 00:00:00
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更新日期：2013-03-01 00:00:00
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doi：
更新日期：2009-07-01 00:00:00
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journal_title：Archives of Iranian medicine
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doi：0011144/AIM.0015
更新日期：2011-07-01 00:00:00
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pub_type： 杂志文章,评审
doi：
更新日期：2009-09-01 00:00:00
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pub_type： 历史文章,杂志文章
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pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
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journal_title：Archives of Iranian medicine
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