Abstract：
BACKGROUND:Non-antifungal drugs appear promising in treatment of opportunistic infections of Candida spp. that are often resistant to current antifungals. METHODS:The broth macrodilution method (NCCLS M27-P document) was used to compare the antifungal activity of trifluoperazine, propranolol, and lansoprazole with that of ketoconazole and amphotericin B, using 50 yeast isolates from the GI tract. The minimum fungicidal concentrations (MFCs), resistance rates and the time required for fungicidal activity of the drugs (2 - 48 hours) were determined. RESULTS:The most effective antifungal activity was exhibited by trifluoperazine. Its MFC was 32 µg/mL for Candida albicans (3.3% resistance) and Candida spp. (0% resistance) yeasts, and 64 µg/mL for Candida tropicalis with 10% resistance. The MFC for C. albicans and Candida spp. was comparable to that of ketoconazole. However, the time required for the inhibitory effect (6 hr) was shorter than that of ketoconazole (48 hr) or amphotericin B (24 hr). The time required for the inhibitory activity on C. tropicalis was 24 hr, which was shorter than that of ketoconazole and amphotericin B (48 hr). A considerable number (40%) of Candida spp. showed resistance to ketoconazole, and 20% of C. tropicalis showed resistance to amphotericin B. Trifluoperazine, an antipsychotic drug, exhibited effective antifungal activity with the MFC, comparable to ketoconazole (32 µg/mL). Among the three yeast groups, C. tropicalis showed resistance to trifluoperazine and amphotericin B, and Candida spp. was considerably resistant to ketoconazole. CONCLUSION:Trifluoperazine could be considered as an alternative antifungal when encountering Candida spp. resistant to current antifungals.
journal_name
Arch Iran Medjournal_title
Archives of Iranian medicineauthors
Siavoshi F,Tavakolian A,Foroumadi A,Hosseini NM,Massarrat S,Pedramnia S,Saniee Pdoi
012151/AIM.009subject
Has Abstractpub_date
2012-01-01 00:00:00pages
27-31issue
1eissn
1029-2977issn
1735-3947pii
009journal_volume
15pub_type
杂志文章abstract：BACKGROUND:Functional foods are extensively studied for their cancer preventive effects. In the present study, we compared the anti-cancer activity of aqueous extracts of three species of mushrooms including: Pleurotus ostreatus (PAE), Auricularia polytricha (AAE) and Macrolepiota procera (MAE) on COLO-205 cells. METH...
journal_title：Archives of Iranian medicine
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abstract：BACKGROUND:Chorionic Villous Sampling (CVS) is a diagnostic method for determining genetic disorders. The present study aimed to determine the negative predictive value of the CVS in the diagnosis of major thalassemia in genetic laboratory of Dastgheib Hospital, Shiraz, Iran. METHODS:The present research was an evalua...
journal_title：Archives of Iranian medicine
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journal_title：Archives of Iranian medicine
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更新日期：2009-07-01 00:00:00
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journal_title：Archives of Iranian medicine
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journal_title：Archives of Iranian medicine
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journal_title：Archives of Iranian medicine
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pub_type： 杂志文章,随机对照试验
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更新日期：2012-08-01 00:00:00
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更新日期：2010-09-01 00:00:00
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更新日期：2015-04-01 00:00:00
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journal_title：Archives of Iranian medicine
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更新日期：2006-07-01 00:00:00
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journal_title：Archives of Iranian medicine
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journal_title：Archives of Iranian medicine
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更新日期：2017-11-01 00:00:00
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更新日期：2019-02-01 00:00:00
