Abstract:
BACKGROUND:Genetic and expression anomaly of HER-2 have been frequently observed in different cancers. However, an overall association of HER-2 polymorphism (Ile655Val) with available cancer studies has not yet been explored. In the present study, a probable correlation of HER-2 Ile655Val polymorphism with 6 major types of cancers including breast, lung, gastric, ovarian, thyroid and uterine has been collectively assessed. METHODOLOGY:Extensive data mining was performed using online available medical research databanks including Pubmed, Ovid, Medline and Embase. Research articles were retrieved based on common keywords "HER-2, polymorphism, (SNP) and cancer (including breast, gastric, lung, ovarian, thyroid and uterine). A database was maintained and updated for case control studies of HER-2 genotype Ile655Val (rs1136201) information until February 2015. Based on selection criteria, a total of 41 studies containing 37,111 subjects (17845 patients, 19266 controls) were selected for thorough insight about HER-2. RESULTS:A significant risk association of HER-2 Ile655Val polymorphism was observed in different types of cancer using various genetic models (co-dominant heterogeneous Ile/Val vs Ile/Ile; OR=1.1, 95% CI = 1.01-1.16, P = 0.01 and dominant; OR = 1.12, 95% CI = 1.03-1.20, P = 0.0003). Interestingly, a strong correlation of Ile655Val heterogeneity was seen in the stratified subgroup of different population including African-American (co-dominant homogenous Val/Val vs Ile/Ile; OR = 8.7, 95% CI = 2.5-30.4, P = 0.0001, dominant; OR = 1.3, 95% CI = 1.03-1.7, P = 0.003; recessive; OR = 8.3, 95% CI = 2.4-28, P = 0.0002), Caucasians (co-dominant heterogeneous Ile/Val vs Ile/Ile; OR = 1.1, 95% CI = 1.0 - 1.2, P = 0.03, dominant; OR = 1.12, 95% CI = 1.0-1.2, P = 0.01). However, in Asian ethnic group, Ile655Val polymorphism lacked a significant association with cancer. This may be attributed to limited studies explored so far. CONCLUSION:In summary, the current study reveals a significant association between cancer susceptibility and the HER-2 Ile655Val polymorphism in all genetic models.
journal_name
Arch Iran Medjournal_title
Archives of Iranian medicineauthors
Riaz SK,Rashid MM,Kayani MA,Arshad Malik MFdoi
0161906/AIM.0011subject
Has Abstractpub_date
2016-06-01 00:00:00pages
430-8issue
6eissn
1029-2977issn
1735-3947pii
0011journal_volume
19pub_type
杂志文章,meta分析,评审abstract::The coronavirus infection is an evolving pandemic with high morbidity and mortality, especially in people with comorbidities. The case fatality rate (CFR) is 9.2% in the presence of diabetes, while it is 1.4% in those without any comorbidity. Diabetes is a prevalent disease globally; hence, healthcare professionals ar...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:10.34172/aim.2020.61
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Alzheimer and Parkinson diseases (AD and PD) are the two most important neurodegenerative disorders. This paper aims to determine the possible molecular linkage between these two common neurodegenerative diseases by a combination of computational investigations. METHODS:According to our aim, common sets of ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0161902/AIM.007
更新日期:2016-02-01 00:00:00
abstract::Nationwide implementation of Family Physician (FP) program started in 2005 and targeted almost 25,000,000 citizens residing in rural areas and cities with less than 20,000 populations in Iran. Despite its blatant initiation that resulted in some modest achievements, the future of FP looks unclear in Iran. Thus far, no...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0141711/AIM.0012
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Polycystic ovary syndrome is not uncommon in women of reproductive age. We conducted this study to determine the clinical, hormonal, and biochemical effects of metformin therapy on girls with polycystic ovary syndrome. METHODS:In a self-controlled clinical trial conducted at the Gynecology Center of Yahyane...
journal_title:Archives of Iranian medicine
pub_type: 临床试验,杂志文章
doi:07102/AIM.0010
更新日期:2007-04-01 00:00:00
abstract:INTRODUCTION:This research aims to determine the mental health status of population aged 15 and over in the province of Razavi Khorasan in 2015. METHODS:The statistical population of this cross-sectional field survey consisted of residents of urban and rural areas of Razavi Khorasan in Iran. An estimated sample size o...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2017-11-01 00:00:00
abstract::This study assessed changes in global and regional systolic left ventricular function after successful percutaneous recanalization of coronary artery occlusions. A consecutive series of 110 patients with mean+/-SD age of 53.6+/-9.1 years, in whom a complete angiographic evaluation was available before angioplasty, und...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:07103/AIM.0020
更新日期:2007-07-01 00:00:00
abstract:INTRODUCTION:This research aims to determine the mental health status of population aged 15 and over in the province of Chaharmahal and Bakhtiari in 2015. METHODS:The statistical population of this cross-sectional field survey consisted of residents of urban and rural areas of Chaharmahal and Bakhtiari in Iran. An est...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Advanced computed tomography (CT) scanners enable concurrent assessment of coronary artery anatomy and myocardial perfusion. The purpose of this study was to assess dual-energy CT images in a group of patients suspected for ischemic heart disease and to evaluate agreement of cardiac computed tomography perfu...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2019-07-01 00:00:00
abstract::Actinomycotic infections are known to be associated with difficulties in making the diagnosis and treatment. Actinomycosis of the tongue is rare and of great importance, not only because it can mimic many other diseases, but also because the tongue itself has some histophysiologic features that make it resistant to in...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00
abstract:: Intellectual Disability (ID, also known as mental retardation) is a debilitating neurodevelopmental disorder affecting nearly 1% of the general population worldwide. Occurrence of behavioral disorders in individuals with ID is four times higher than that in the general population. An increasing number of studies seek...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,评审
doi:0161905/AIM.0012
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Suicide is among the top 20 leading causes of death globally in all age groups and it is still a significant social and public health problem. METHODS:Data on suicide deaths in 1987-2011 were extracted from the Turkish Statistical Institute mortality dataset based on ICD-9 and ICD-10 codes. The temporal tre...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:015186/AIM.006
更新日期:2015-06-01 00:00:00
abstract::As there is a significant number of Iranian immigrant and illegal refugees living in marginal areas of large cities that might induce immunization gap in these areas. The aim of this study was to provide reliable information on vaccination status of these people. A cross sectional study was conducted on children 24-4...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0141710/AIM.0011
更新日期:2014-10-01 00:00:00
abstract::Systemic therapy is one of the cornerstones of cancer treatment. In 1972, following representations by American Society of Clinical Oncology (ASCO), the American Board of Internal Medicine (ABIM) recognized medical oncology as a new subspecialty of internal medicine. Subspecialty of Hematology and Medical Oncology was...
journal_title:Archives of Iranian medicine
pub_type: 历史文章,杂志文章
doi:0151811/AIM.0013
更新日期:2015-11-01 00:00:00
abstract::The history of early attempts of blood transfusion in Iran traces back to the 1940s; however, around three decades later in 1974, the Iranian National Blood Transfusion Service (Sazeman-e Melli-e Enteqal-e Khun-e Iran) was founded by the outstanding hematologist, Professor Fereydoun Ala. The main goals of this central...
journal_title:Archives of Iranian medicine
pub_type: 传,历史文章,杂志文章
doi:015186/AIM.0016
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Cystic craniopharyngiomas are the most frequent intracranial neoplasm of nonglial origin in children. Follow-up data were analyzed to assess the value of intracavitary irradiation with stereotactically applied 32P radioisotopes for the treatment of patients with craniopharyngioma cysts admitted to Shohada Ta...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:08111/AIM.009
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Previous studies reported the association between dietary patterns and prevalence of diabetes, cardiovascular disease and other chronic disease. However, there are no studies reporting major dietary patterns in patients awaiting coronary artery bypass graft surgery (CABG). The aim of this study was to obtain...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0161907/AIM.005
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Glutaric Aciduria type 1 (GA1) is a metabolic inborn error and is characterized by increasing excursion of glutaric acid and its derivates, presented in microcephaly and dystonia. The disease is resulted from mutational inactivation in the GCDH gene encoding the glutaryl-CoA dehydrogenase. The defective enzy...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0141709/AIM.009
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:There is controversial data available regarding the impact of age at menarche on cardio-metabolic parameters. This community-based study aimed to assess this association among Iranian women. METHODS:We recruited 5,344 eligible women out of 7718, aged 10-50 years who participated in the Tehran lipid and gluc...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Physical inactivity is one of the leading causes of major chronic disease, which contributes substantially to the global burden of disease, death and disability. This study examined physical activity in a randomly selected sample of elderly people in Tehran, Iran. METHODS:A random sample of 400 elderly peop...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:010136/0014
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Wrong beliefs about risky actions such as sunbathing and tanning are common due to media advertisements or general lack of knowledge. This work has focused on the knowledge and attitude of a group of citizens in Tehran, Iran and the protective actions they take regarding undesirable effects of the sun. M...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:011142/AIM.0011
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:The need for mental health care among children and adolescents in Iran, as in other low and middle income countries (LAMIC) remains mostly unmet. In this paper, we sought to provide an overview of the extent of unmet need and mental health services in Iran. We also aimed to propose approaches to address this...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0161911/AIM.0010
更新日期:2016-11-01 00:00:00
abstract::Longitudinal studies are very common in medical, behavioral, and interventional sciences. One measure of effect of interest in longitudinal studies is risk ratio, naturally estimated by log-binomial regression which suffers from convergence problem. Odds ratio does not well approximate risk ratio when the outcome is c...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The threshold of thyroid-stimulating hormone (TSH) in current screening for congenital hypothyroidism (CH) from the heel prick test is 5 mU/l. This study uses cost-effective analysis to evaluate increasing the threshold to minimize false-positive results and recall rates. METHODS:Cost of screening, diagnosi...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:012153/AIM.006
更新日期:2012-03-01 00:00:00
abstract:INTRODUCTION:Recent advances in pharmacy practice have created serious ethical challenges for the pharmacists. Pursuing a new philosophy of practice is required to overcome these challenges and optimize the standard of care. In this regard, the current ethics guideline in the Pharmacy curriculum used in Tehran Universi...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0172001/AIM.009
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Platelet concentrates (PC) are used in thrombocytopenia and inherited or acquired platelet dysfunction disorders. Thus, retaining the platelets quality and function during storage will lead to desirable outcomes in treatment of such patients. METHODS: In this study, we evaluated 40 PC bags, ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:015182/AIM.0010
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:It is well known that inhalation of chemical warfare, mostly sulfur mustard, causes injury of the respiratory system. Chronic obstructive pulmonary disease is a common disease among these patients. Health-related quality of life is a common feature of studies in chronic obstructive pulmonary disease. The obj...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Estrogen is the major sex steroid affecting the growth, remodeling, and homeostasis of the female skeleton. Estrogen loss in postmenopausal women leads to osteoporosis. The aim of this study was to evaluate the early and long- term effects of estrogen loss on bones, tendons, muscles, and menisci in ovariecto...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:013165/AIM.006
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Because resistance to antifungal drugs is seen in patients, susceptibility testing of these drugs aids in choosing the appropriate drug and respective epidemiology. This study has investigated and compared susceptibility patterns of the Aspergillus species isolated from patients by the Clinical and Laborator...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:012157/AIM.0011
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:This study ascertained the effects of soy, in the forms of textured soy protein (TSP) and soy nuts, on lipid profiles, apolipoproteins, inflammatory and prothrombotic markers, and blood pressure in elderly women diagnosed with metabolic syndrome (MetS). METHODS:This was a 12-week parallel, randomized, contr...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,随机对照试验
doi:012158/AIM.004
更新日期:2012-08-01 00:00:00
abstract:UNLABELLED: BACKGROUND:Potato, a high- glycemic index (GI) food, is one of the most widely used starchy foods worldwide. Previous studies on the association of dietary intakes with stroke have mostly focused on the dietary GI and there is no information regarding the association between potato consumption and risk of...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:013163/AIM.009
更新日期:2013-03-01 00:00:00