Abstract：
BACKGROUND:Thalassemia major and its treatment by stem cell transplantation can have deleterious effects on bone integrity. This study assesses the adverse effects of transplantation on growing bones of pediatric thalassemic patients. METHODS:Bone mineral density (BMD) of 20 patients from three thalassemia classes whose mean (SD) age was 7.4 (3.8) years were tested with a Norland XR-46 device at baseline (before transplantation), 6 and 12 months after transplantation. RESULTS:At 6 and 12 months after transplantation we observed no significant changes in mean BMD. There were no Z-scores less than -2 among patients. Class 3 thalassemia did not negatively impact BMD. Calcium (Ca), phosphorous (P) and ferritin levels were not significantly related to patients' BMD scores. Transfusion duration and chelation therapy showed positive significant relationships to BMD (g/cm(2)), but no significant relation with the BMD Z-score. The deleterious relation between corticosteroid use and changes in BMD was not significant. In contrast, patients who developed acute graft versus host disease (aGVHD) after transplantation showed significant adverse effects on BMD of their femur (P = 0.020) and spine (P = 0.027). CONCLUSION:Stem cell transplantation in pediatric thalassemic patients who do not develop aGVHD does not appear to have any significant positive or negative effects on BMD.
journal_name
Arch Iran Medjournal_title
Archives of Iranian medicineauthors
Hamidieh AA,Hamidi Z,Nedaeifard L,Heshmat R,Alimoghaddam K,Larijani B,Ghavamzadeh A,Mohajeri-Tehrani MRdoi
013162/AIM.008subject
Has Abstractpub_date
2013-02-01 00:00:00pages
88-92issue
2eissn
1029-2977issn
1735-3947pii
008journal_volume
16pub_type
杂志文章abstract：BACKGROUND:Estrogen is the major sex steroid affecting the growth, remodeling, and homeostasis of the female skeleton. Estrogen loss in postmenopausal women leads to osteoporosis. The aim of this study was to evaluate the early and long- term effects of estrogen loss on bones, tendons, muscles, and menisci in ovariecto...
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更新日期：2013-05-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2012-09-01 00:00:00
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更新日期：2016-01-01 00:00:00
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更新日期：2009-01-01 00:00:00
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更新日期：2012-01-01 00:00:00
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doi：
更新日期：2010-03-01 00:00:00
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更新日期：2015-11-01 00:00:00
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更新日期：2015-05-01 00:00:00
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更新日期：2017-08-01 00:00:00
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journal_title：Archives of Iranian medicine
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更新日期：2018-11-01 00:00:00
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更新日期：2016-08-01 00:00:00
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更新日期：2011-07-01 00:00:00
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更新日期：2017-01-01 00:00:00
