Circadian cycles are the dominant transcriptional rhythm in the intertidal mussel Mytilus californianus.

abstract：:PSD-95 is a scaffolding protein that regulates the synaptic localization of many receptors, channels, and signaling proteins. The NLGN gene family encodes single-pass transmembrane postsynaptic cell adhesion molecules that are important for synapse assembly and function. At excitatory synapses, NLGN1 mediates transsyn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeong J,Pandey S,Li Y,Badger JD 2nd,Lu W,Roche KW

更新日期：2019-06-11 00:00:00

abstract：:The region of the simian virus 40 genome complementary to the 5' end of the most abundant poly(A)-containing 19S and 16S mRNAs was mapped by hybridization of double-labeled RNA ([3H]methyl group and [14C]uridine) to specific DNA fragments. Chemical identification of methylated residues indicated that a common "leader"...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lavi S,Groner Y

更新日期：1977-12-01 00:00:00

abstract：:The bacterial pathogen Pseudomonas tolaasii severely damages white button mushrooms by secretion of the pore-forming toxin tolaasin, the main virulence factor of brown blotch disease. Yet, fungus-associated helper bacteria of the genus Mycetocola (Mycetocola tolaasinivorans and Mycetocola lacteus) may protect their ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hermenau R,Kugel S,Komor AJ,Hertweck C

更新日期：2020-09-22 00:00:00

abstract：:Cancer stem cells (CSCs) sustain tumor growth through their ability to self-renew and to generate differentiated progeny. These functions endow CSCs with the potential to initiate secondary tumors bearing characteristics similar to those of the parent. Recently the hair follicle stem cell marker CD34 was used to purif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schober M,Fuchs E

更新日期：2011-06-28 00:00:00

abstract：:Declining biodiversity and ecosystem functions put many of nature's contributions to people at risk. We review and synthesize the scientific literature to assess 50-y global trends across a broad range of nature's contributions. We distinguish among trends in potential and realized contributions of nature, as well as ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brauman KA,Garibaldi LA,Polasky S,Aumeeruddy-Thomas Y,Brancalion PHS,DeClerck F,Jacob U,Mastrangelo ME,Nkongolo NV,Palang H,Pérez-Méndez N,Shannon LJ,Shrestha UB,Strombom E,Verma M

更新日期：2020-12-22 00:00:00

abstract：:Absolute pitch (AP) is the rare ability to identify the pitch of a tone without the aid of a reference tone. Understanding both the nature and genesis of AP can provide insights into neuroplasticity in the auditory system. We explored factors that may influence the accuracy of pitch perception in AP subjects both duri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Athos EA,Levinson B,Kistler A,Zemansky J,Bostrom A,Freimer N,Gitschier J

更新日期：2007-09-11 00:00:00

abstract：:The chemosmotic model provides a framework for visualizing energy-coupled reactions (vectorial reaction sequences, membrane-dependent gradient formation, and charge separation of reacting species) and a mechanism for energy coupling (indirect coupling between the driving and driven reaction sequences mediated by a mem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Green DE

更新日期：1981-04-01 00:00:00

abstract：:Clostridium difficile, a causative agent of antibiotic-associated diarrhea and its potentially lethal form, pseudomembranous colitis, produces two large protein toxins that are responsible for the cellular damage associated with the disease. The level of toxin production appears to be critical for determining the seve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mani N,Dupuy B

更新日期：2001-05-08 00:00:00

abstract：:Mechanical robustness of the cell under different modes of stress and deformation is essential to its survival and function. Under tension, mechanical rigidity is provided by the cytoskeletal network; with increasing stress, this network stiffens, providing increased resistance to deformation. However, a cell must als...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou EH,Trepat X,Park CY,Lenormand G,Oliver MN,Mijailovich SM,Hardin C,Weitz DA,Butler JP,Fredberg JJ

更新日期：2009-06-30 00:00:00

abstract：:Obesity is a major public health problem and is often associated with type 2 diabetes mellitus, cardiovascular disease, and metabolic syndrome. Leptin is the crucial adipostatic hormone that controls food intake and body weight through the activation of specific leptin receptors (OB-R) in the hypothalamic arcuate nucl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Couturier C,Sarkis C,Séron K,Belouzard S,Chen P,Lenain A,Corset L,Dam J,Vauthier V,Dubart A,Mallet J,Froguel P,Rouillé Y,Jockers R

更新日期：2007-12-04 00:00:00

abstract：:Learning the properties of an image associated with human gaze placement is important both for understanding how biological systems explore the environment and for computer vision applications. There is a large literature on quantitative eye movement models that seeks to predict fixations from images (sometimes termed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kümmerer M,Wallis TS,Bethge M

更新日期：2015-12-29 00:00:00

abstract：:Ascorbic acid metabolism is associated with a number of mechanisms known to be involved in host resistance to malignant disease. Cancer patients are significantly depleted of ascorbic acid, and in our opinion this demonstrable biochemical characteristic indicates a substantially increased requirement and utilization o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cameron E,Pauling L

更新日期：1976-10-01 00:00:00

abstract：:Lipid-mediated signaling events regulate many cellular processes. Investigations of the complex underlying mechanisms are difficult because several different methods need to be used under varying conditions. Here we introduce multifunctional lipid derivatives to study lipid metabolism, lipid-protein interactions, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Höglinger D,Nadler A,Haberkant P,Kirkpatrick J,Schifferer M,Stein F,Hauke S,Porter FD,Schultz C

更新日期：2017-02-14 00:00:00

abstract：:Despite growing evidence for perceptual interactions between motion and position, no unifying framework exists to account for these two key features of our visual experience. We show that percepts of both object position and motion derive from a common object-tracking system--a system that optimally integrates sensory...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwon OS,Tadin D,Knill DC

更新日期：2015-06-30 00:00:00

abstract：:Parathyroid hormone (PTH), the major calcium-regulating hormone, and norepinephrine (NE), the principal neurotransmitter of sympathetic nerves, regulate bone remodeling by activating distinct cell-surface G protein-coupled receptors in osteoblasts: the parathyroid hormone type 1 receptor (PTHR) and the β(2)-adrenergic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hanyu R,Wehbi VL,Hayata T,Moriya S,Feinstein TN,Ezura Y,Nagao M,Saita Y,Hemmi H,Notomi T,Nakamoto T,Schipani E,Takeda S,Kaneko K,Kurosawa H,Karsenty G,Kronenberg HM,Vilardaga JP,Noda M

更新日期：2012-05-08 00:00:00

abstract：:The ASCAPE agent-based modeling environment greatly eases the task of designing and investigating agent-based models. However, effective design can still require a relatively deep knowledge of programming and agent-based modeling. This issue has almost certainly slowed the adoption of agent-based modeling approaches t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inchiosa ME,Parker MT

更新日期：2002-05-14 00:00:00

abstract：:The spread of bacteria resistant to antimicrobial agents calls for population-wide treatment strategies to delay or reverse the trend toward antibiotic resistance. Here we propose new criteria for the evaluation of the population-wide effects of treatment protocols for directly transmitted bacterial infections and dis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonhoeffer S,Lipsitch M,Levin BR

更新日期：1997-10-28 00:00:00

abstract：:Many changes have been described in the brains of Alzheimer's disease (AD) patients, including loss of neurons and formation of senile plaques and neurofibrillary tangles. The molecular mechanisms underlying these pathologies are unclear. Northern blot, dot-blot, and reverse transcription-coupled PCR analyses have dem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chow N,Cox C,Callahan LM,Weimer JM,Guo L,Coleman PD

更新日期：1998-08-04 00:00:00

abstract：:Spontaneous regression/complete resistance (SR/CR) mice resist very high doses of cancer cells that are lethal to WT mice even at low doses. In this study, we show that this resistance is mediated by rapid infiltration of leukocytes, mostly of innate immunity, in both primary and repeated challenges. Formation of rose...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hicks AM,Riedlinger G,Willingham MC,Alexander-Miller MA,Von Kap-Herr C,Pettenati MJ,Sanders AM,Weir HM,Du W,Kim J,Simpson AJ,Old LJ,Cui Z

更新日期：2006-05-16 00:00:00

abstract：:The promoter of the bean PAL2 gene (encoding phenylalanine ammonia-lyase; EC 4.3.1.5) is a model for studies of tissue-restricted gene expression in plants. Petal epidermis is one of the tissues in which this promoter is activated in tobacco. Previous work suggested that a major factor establishing the pattern of PAL2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sablowski RW,Baulcombe DC,Bevan M

更新日期：1995-07-18 00:00:00

abstract：:In eukaryotic cells, RAD52 protein plays a central role in genetic recombination and DNA repair by (i) promoting the annealing of complementary single-stranded DNA and (ii) stimulation of the RAD51 recombinase. The single-strand annealing domain resides in the N-terminal region of the protein and is highly conserved, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singleton MR,Wentzell LM,Liu Y,West SC,Wigley DB

更新日期：2002-10-15 00:00:00

abstract：:Rabbit articular chondrocytes synthesize type II collagen [3alpha(1)(II)] in vivo and type I collagen [2alpha(1)(I).alpha(2)] in monolayer cultures. In suspension culture the nature of phenotype depends on extracellular Ca(2+). The relationship of Ca(2+) and 3':5'-cyclic AMP (cAMP) in regulation of collagen synthesis ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deshmukh K,Sawyer BD

更新日期：1977-09-01 00:00:00

abstract：:Heavy (H) chain binding protein (BiP), which binds to free immunoglobulin H chain of the mu and gamma classes, can be demonstrated in pre-B-cells. It is proposed that the displacement of BiP from H chain by light (L) chain terminates the activity of the enzyme system, L-generase, which catalyzes DNA rearrangement at t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wabl M,Steinberg C

更新日期：1982-11-01 00:00:00

abstract：:The identification and targeting of key molecular drivers of melanoma and breast and lung cancer have substantially improved their therapy. However, subtypes of each of these three common, lethal solid tumors lack identified molecular drivers, and are thus not amenable to targeted therapies. Here we show that pleckstr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Semir D,Bezrookove V,Nosrati M,Dar AA,Wu C,Shen J,Rieken C,Venkatasubramanian M,Miller JR 3rd,Desprez PY,McAllister S,Soroceanu L,Debs RJ,Salomonis N,Schadendorf D,Cleaver JE,Kashani-Sabet M

更新日期：2018-06-19 00:00:00

abstract：:The functional significance of the portal vascular link between the beta cells of the pancreatic islets and the liver has not been established. Previous studies indicated that insulin does not acutely regulate glucose metabolism by a direct hepatic effect. More recent observations suggest that the role of insulin in r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Griffen SC,Russell SM,Katz LS,Nicoll CS

更新日期：1987-10-01 00:00:00

abstract：:The Ah receptor (AHR) is a basic helix-loop-helix protein that mediates the effects of 2,3,7,8-tetrachloro-dibenzo-p-dioxin. In this report, we describe a rabbit reticulocyte system that allows functional expression of both the AHR and its dimeric partner, the AHR nuclear translocator protein (ARNT). By using this in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dolwick KM,Swanson HI,Bradfield CA

更新日期：1993-09-15 00:00:00

abstract：:From a flounder pituitary cDNA library, cDNA clones encoding a 28-kDa glycoprotein produced by the pars intermedia of the pituitary were isolated and characterized. Nucleotide sequencing demonstrated a precursor of the 28-kDa protein, which consisted of 231 amino acid residues, to be cleaved into a signal peptide (24 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ono M,Takayama Y,Rand-Weaver M,Sakata S,Yasunaga T,Noso T,Kawauchi H

更新日期：1990-06-01 00:00:00

abstract：:Many cortical neurons combine the information ascending and descending the cortical hierarchy. In the classical view, this information is combined nonlinearly to give rise to a single firing-rate output, which collapses all input streams into one. We analyze the extent to which neurons can simultaneously represent mul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naud R,Sprekeler H

更新日期：2018-07-03 00:00:00

abstract：:The histidine periplasmic permease of Salmonella typhimurium has been partially purified and reconstituted into proteoliposomes. In this in vitro preparation, transport activity is completely dependent on the presence of all four permease proteins (HisJ, HisQ, HisM, and HisP) and on internal ATP. The reconstituted sys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bishop L,Agbayani R Jr,Ambudkar SV,Maloney PC,Ames GF

更新日期：1989-09-01 00:00:00

abstract：:Coherent multidimensional electronic spectroscopy is commonly used to investigate photophysical phenomena such as light harvesting in photosynthesis in which the system returns back to its ground state after energy transfer. By contrast, we introduce multidimensional spectroscopy to study ultrafast photochemical proce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruetzel S,Diekmann M,Nuernberger P,Walter C,Engels B,Brixner T

更新日期：2014-04-01 00:00:00