Abstract:
:Omalizumab is currently used in severe asthma and has been tried in other allergic disorders. The authors report two patients with multiple food allergies and eosinophilic esophagitis on a very restrictive diet who have been treated with omalizumab, in order to improve food intolerance--the major distressing factor in their lives. The patients significantly improved in the reported symptoms. However, no improvement was seen regarding esophageal endoscopy and histology. Given the poor histological and endoscopy response, eosinophilic esophagitis persistence is unlikely to be IgE dependent. Omalizumab may improve the quality of life of patients with severe food allergy by improving symptoms, but it does not appear to change endoscopic and histological features of eosinophilic esophagitis in a short follow-up.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Rocha R,Vitor AB,Trindade E,Lima R,Tavares M,Lopes J,Dias JAdoi
10.1007/s00431-011-1540-4subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1471-4issue
11eissn
0340-6199issn
1432-1076journal_volume
170pub_type
杂志文章abstract::Biochemical markers such as plasma and urinary metabolite concentrations and in vitro enzyme activity are of limited prognostic value in the most common disorders of propionate metabolism, methylmalonic acidaemia (MMA) and propionic acidaemia (PA). In vivo propionate oxidation was compared with conventional prognostic...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02009661
更新日期:1990-03-01 00:00:00
abstract::We report a 13 year-old girl with manifestations strikingly reminiscent of the tricho-rhino-phalangeal (TRP) II or Langer-Giedion syndrome. A terminal deletion of 8q must be assumed to be the cause of her condition till proven otherwise. A similar chromosome abnormality should be searched for (blindly) in other cases ...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00441586
更新日期:1980-03-01 00:00:00
abstract::A case of painful bilateral hip effusions resolving spontaneously in the diuretic phase of steroid responsive nephrotic syndrome in a 6-year-old girl is reported. ...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02072499
更新日期:1993-02-01 00:00:00
abstract::The total height gain was studied in 19 adult male subjects with non-tumorous hypopituitarism after they had been treated with human growth hormone (hGH) for more than 3 years and achieved final adult height. In patients with a history of breech delivery or severe perinatal asphyxia, a high multiple correlation was fo...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00442688
更新日期:1988-04-01 00:00:00
abstract::Serum immunoglobulin levels and naturally occurring antibody titres against Streptococcus pneumoniae were measured in seven children aged 1-1.9 years with recurrent pneumococcal acute otitis media (AOM). Three of them had low IgG2 levels. Mean antibody levels of anti-pneumococcal IgG1 and anti-pneumococcal IgG2 were s...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01958979
更新日期:1994-03-01 00:00:00
abstract:UNLABELLED:Intensive multimodality treatment has led to a remarkable improvement of prognosis in paediatric cancer patients, however, a great number of long-term survivors suffer from considerable tumour- or treatment-related late effects. Between January 1990 and December 1998, 223 consecutive survivors of childhood m...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/pl00008340
更新日期:2000-10-01 00:00:00
abstract:UNLABELLED:The aim of the study was to determine the characteristic features and outcome of carcinoid or mucoepidermoid tumours in children. A retrospective analysis of all patients treated for a carcinoid or mucoepidermoid tumour in France between 1984 and 2001 was performed. There were 11 cases of carcinoid tumour an...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-005-1740-x
更新日期:2005-12-01 00:00:00
abstract::Before promoting certain types of physical activities, the Health Promotion and Disease Prevention Department of Malta wanted to know whether children knew how to perform them in the first place, and if not, what barriers they had encountered. A cross-sectional, self-reported study involved 11-year-old students (boys ...
journal_title:European journal of pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1007/s00431-010-1185-8
更新日期:2010-09-01 00:00:00
abstract::Recombinant interleukin 2 (rIL2) was administered to a patient with Wiskott-Aldrich syndrome for the treatment of an intractable facial herpetiform lesion. This treatment appeared to be effective in suppressing the virus activity. At the same time, a transient improvement of the chronic eczematoid dermatitis was obser...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01957224
更新日期:1993-12-01 00:00:00
abstract::Soon after birth a 36-week-gestational age, appropriate for dates, newborn infant developed hyperinsulinaemic hypoglycaemia which responded to diazoxide and glucose infusion. While normoglycaemic, he became increasingly ill with high lactate, pyruvate, and alanine levels. Provocation tests suggested a defect in lactat...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00496802
更新日期:1983-12-01 00:00:00
abstract:UNLABELLED:Two patients are described with acute collapse caused by pericardial effusion following central venous catheterisation. Echocardiography during resuscitation allowed prompt identification and management. CONCLUSION:Pericardial effusion should be considered in any baby experiencing acute deterioration with a...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s004310100828
更新日期:2001-12-01 00:00:00
abstract::The unfavorable impact of prematurity on the developing cerebellum was recently recognized, but the outcome after impaired cerebellar development as a prematurity-related complication is hitherto not adequately documented. Therefore we compared 31 preterm patients with disrupted cerebellar development to a control gro...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-007-0647-0
更新日期:2008-10-01 00:00:00
abstract:UNLABELLED:Tracheal bronchus (TB) associated with VACTERL has not been reported previously. A 5-month-old girl with VACTERL association was ventilator-dependent following surgical closure of a patent ductus arteriosus (PDA). Chest radiographs showed persistent hyperinflation of the right upper lobe. Bronchoscopy showed...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-002-1109-3
更新日期:2003-03-01 00:00:00
abstract::Serial ultrasound examinations were performed through the anterior fontanelle to detect and follow subependymal pseudocysts (SP) in 19 neonates without severe malformations. A high-resolution real-time sector scanner was employed. In 8 cases the SP involved both lateral ventricles, in 11 cases they were unilateral and...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00595915
更新日期:1989-02-01 00:00:00
abstract::We have evaluated 46 patients with Turner syndrome by clinical examination, M-mode and two-dimensional echocardiography, dynamic exercise testing and 24 h Holter monitoring. Twelve patients (26.1%) had mitral valve prolapse and 7 patients (15.2%) had isolated non stenotic bicuspid aortic valve. Aortic root dilation wa...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00441551
更新日期:1989-04-01 00:00:00
abstract::Four months after termination of successful chemotherapy for epipharyngeal B-non-Hodgkin lymphoma, an enlarging anterior mediastinal mass was discovered in a 15-year-old boy. There was no other suspicion of tumour recurrence. A simple thymic rebound was likely and a conservative management was chosen. Follow up for mo...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01958950
更新日期:1992-02-01 00:00:00
abstract::In a five-year-old girl with congenital hepatic fibrosis raised erythrocyte sedimentation rate and serum gammaglobulins were noted for 3 years. Needle liver biopsy showed histological features of cholangitis and Klebsiella oxytoca was cultured from a liver biopsy specimen. Antibiotic treatment resulted in normalizatio...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01377359
更新日期:1982-11-01 00:00:00
abstract::In the serum of two infant sisters with a congenital renal salt-losing syndrome, Na was rather low and K considerably increased. Even with Na levels of 126 mval/1, sodium was excreted in the urine. Creatinine and hippurate clearances were normal. Primary disturbances of the steroid metabolism were not detectable; plas...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00443063
更新日期:1976-01-02 00:00:00
abstract:UNLABELLED:To examine the value of surfactant protein D and KL-6 as markers for the diagnosis and the severity of interstitial pneumonia caused by measles infection, surfactant protein D, KL-6 and lactic acid dehydrogenase were measured serially in three patients with measles complicated by interstitial pneumonia as co...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s004310100763
更新日期:2001-07-01 00:00:00
abstract:UNLABELLED:Methanol poisoning is not frequently observed in children; however, without treatment, serious intoxication can be complicated by visual impairment, coma, metabolic acidosis, respiratory and circulatory insufficiency and death. Treatment in a paediatric intensive care is therefore compulsory. Methanol is met...
journal_title:European journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s00431-004-1588-5
更新日期:2005-03-01 00:00:00
abstract:UNLABELLED:There are a number of respiratory diseases affecting infants in which there is surfactant dysfunction or deficiency. Surfactant is inactivated by cholesterol, free fatty acids and bilirubin in meconium aspiration syndrome, by haemoglobin and red blood cell lipids in pulmonary haemorrhage and plasma proteins ...
journal_title:European journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/pl00008398
更新日期:2000-09-01 00:00:00
abstract::A South African family with autosomal dominant split hand, split foot (SHSF) malformation has been studied. The pedigree was unusual in that three unaffected siblings with normal parents had each produced affected offspring. New mutation, germinal mosaicism and autosomal recessive inheritance are unlikely. Possible ex...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00442225
更新日期:1988-02-01 00:00:00
abstract::Two siblings became very ill after BCG inoculation in the newborn period. A generalized BCG infection was assumed from the clinical symptomatology and the histological findings. Later on the boy suffered from enteric salmonellosis and osteomyelitis caused by the same organism, and as a todler he had intestinal pseudot...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00445481
更新日期:1976-02-04 00:00:00
abstract::Infantile hepatic hemangioma is the most common benign liver tumor during infancy. Prompt diagnosis and timely institution of therapy are of utmost importance. Magnetic resonance imaging (MRI) plays a key role in the correct diagnosis and monitoring of treatment. We report on a 15-week-old girl with multifocal infanti...
journal_title:European journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s00431-011-1671-7
更新日期:2012-07-01 00:00:00
abstract::This was a retrospective study documenting all pacemaker implantations (PMIs) secondary to postoperative atrioventricular block. A total of 26 patients were included between 2011 and 2020. The incidence rate was 1.8%, with a median follow-up time of 4.5 years. At the time of the initial PMI, the median weight was 5 kg...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-020-03739-9
更新日期:2020-12-01 00:00:00
abstract:UNLABELLED:Increased plasma tumour necrosis factor alpha (TNF) concentration correlates with mortality in sepsis. We suggested that pentoxifylline (PTXF), which is known to inhibit TNF production, may improve survival and attenuate clinical symptoms of sepsis in neonates. Plasma TNF levels were evaluated in 29 newborn ...
journal_title:European journal of pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01955273
更新日期:1996-05-01 00:00:00
abstract::This was an uncontrolled, open-label follow up study of a previous 12-month, randomized, double-blind, placebo-controlled trial performed to assess the long-term efficacy and safety of Recombinant Human Interferon Gamma (rIFN-gamma) in patients with chronic granulomatous disease (CGD). In two centres, 28 patients (24 ...
journal_title:European journal of pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01957365
更新日期:1995-04-01 00:00:00
abstract::Term born infants are predisposed to human rhinovirus (HRV) lower respiratory tract infections (LRTI) by reduced neonatal lung function and genetic susceptibility. Our aim was to investigate whether prematurely born infants were similarly predisposed to HRV LRTIs or any other viral LRTIs. Infants born less than 36 wee...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-016-2780-0
更新日期:2016-12-01 00:00:00
abstract::Cough and wheezing are the predominant symptoms of acute bronchitis. Hitherto, the evaluation of respiratory symptoms was limited to subjective methods such as questionnaires. The main objective of this study was to objectively determine the time course of cough and wheezing in children with acute bronchitis. The impa...
journal_title:European journal of pediatrics
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00431-019-03426-4
更新日期:2019-09-01 00:00:00
abstract::Serum immunoreactive erythropoietin (siEPO) was determined in cord serum from neonates (n = 97, gestational age 36-43 weeks), in healthy children from birth to adolescence (n = 260) and in children with haematological (n = 30), renal (n = 10) and congenital heart diseases (n = 70). In healthy children siEPO levels dec...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01959395
更新日期:1990-04-01 00:00:00