Omalizumab in the treatment of eosinophilic esophagitis and food allergy.

Abstract:

:Omalizumab is currently used in severe asthma and has been tried in other allergic disorders. The authors report two patients with multiple food allergies and eosinophilic esophagitis on a very restrictive diet who have been treated with omalizumab, in order to improve food intolerance--the major distressing factor in their lives. The patients significantly improved in the reported symptoms. However, no improvement was seen regarding esophageal endoscopy and histology. Given the poor histological and endoscopy response, eosinophilic esophagitis persistence is unlikely to be IgE dependent. Omalizumab may improve the quality of life of patients with severe food allergy by improving symptoms, but it does not appear to change endoscopic and histological features of eosinophilic esophagitis in a short follow-up.

journal_name

Eur J Pediatr

authors

Rocha R,Vitor AB,Trindade E,Lima R,Tavares M,Lopes J,Dias JA

doi

10.1007/s00431-011-1540-4

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

1471-4

issue

11

eissn

0340-6199

issn

1432-1076

journal_volume

170

pub_type

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