Abstract:
:The unfavorable impact of prematurity on the developing cerebellum was recently recognized, but the outcome after impaired cerebellar development as a prematurity-related complication is hitherto not adequately documented. Therefore we compared 31 preterm patients with disrupted cerebellar development to a control group of 31 gender and gestational age matched premature infants with normal cerebellar development. Supratentorial brain injuries during the neonatal period were comparable between the groups. At a minimum age of 24 months motor and mental development was assessed by standardized tests. Disrupted cerebellar development was associated with significantly poorer scores both in the subtests for neuromotor (p < 0.001) and mental development (p < 0.001), respectively. Mixed CP was diagnosed in 48% of affected patients, whereas none of the patients of the control group had mixed CP. Microcephaly and epilepsy were significantly related to disrupted cerebellar development. Preterm patients with disrupted cerebellar development exhibit poorer outcome results in all investigated variables. The role of the cerebellum in neurodevelopment after prematurity seems to be underestimated so far.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Messerschmidt A,Fuiko R,Prayer D,Brugger PC,Boltshauser E,Zoder G,Sterniste W,Weber M,Birnbacher Rdoi
10.1007/s00431-007-0647-0subject
Has Abstractpub_date
2008-10-01 00:00:00pages
1141-7issue
10eissn
0340-6199issn
1432-1076journal_volume
167pub_type
杂志文章abstract::Respiratory syncytial virus (RSV) infection is one of the main causes of infant hospitalization and mortality. The single-stranded RNA virus codes for 11 proteins of which the F protein, a surface epitope responsible for RSV fusion, is the most targeted for developing antiviral medicines and vaccines. The peak of symp...
journal_title:European journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s00431-018-03310-7
更新日期:2019-02-01 00:00:00
abstract::Co-trimoxazole is an effective antibacterial agent for the prophylaxis of urinary tract infection. Because experimental evidence raises the possibility that high-dose cotrimoxazole might interfere with normal somatic growth, the longitudinal growth and growth velocities were analysed in 114 girls receiving long-term, ...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00442669
更新日期:1983-09-01 00:00:00
abstract::We describe the natural history of the RTSII phenotype in a 7-year-old boy who developed intrauterine and postnatal growth retardation, failure to thrive and persisting diarrhoea. The growth hormone stimulation test identified an isolated growth hormone deficiency. Since infancy, the patient manifested skin lesions ch...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-007-0447-6
更新日期:2008-02-01 00:00:00
abstract::Complete masculinisation of the external genitalia (type V of Prader classification) is reported in two siblings with normal internal female genitalia, normal ovaries and a 46,XX chromosome constitution in different cell lines without any detectable source of exposure to androgen during pregnancy. ...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00445596
更新日期:1984-06-01 00:00:00
abstract:UNLABELLED:Non-immune hydrops fetalis may find its origin within genetically determined lymphedema syndromes, caused by mutations in FOXC2 and SOX-18. We describe a newborn girl, diagnosed with non-immune hydrops fetalis at a gestational age of 30 weeks. Family history revealed the presence of an autosomal dominant lat...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-011-1557-8
更新日期:2012-03-01 00:00:00
abstract:UNLABELLED:Delta1-pyrroline-5-carboxylate synthase (P5CS) catalyses the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine. Recently, we reported a newly recognised inborn error due to deficiency of P5CS in two sibs, one presenting at birth w...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-004-1545-3
更新日期:2005-01-01 00:00:00
abstract:UNLABELLED:A survey among centres of the paediatric group of the GTH was performed to evaluate the prevalence and outcome of haemophiliacs with intracerebral haemorrhage. A questionnaire sent to the centres covered the following points: number of patients with severe, moderate and mild haemophilia A and B; for each pat...
journal_title:European journal of pediatrics
pub_type: 杂志文章,多中心研究
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更新日期:1999-12-01 00:00:00
abstract::Iron deficiency is frequently associated with anemia. Iron is a transition-metal ion, and it can induce free radical formation, which leads to formation of various lesions in DNA, proteins, and lipids. The aim of this study was to investigate baseline oxidative DNA damage and to clarify the role of the administration ...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-010-1147-1
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:The severity of childhood gastroenteritis is generally believed to be age-related rather than aetiology-related. Rotavirus-induced gastroenteritis is more severe than gastroenteritis caused by other enteric pathogens and is also age-related. We thus addressed the question of whether the increased severity of...
journal_title:European journal of pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1007/s00431-006-0237-6
更新日期:2007-03-01 00:00:00
abstract:UNLABELLED:Aim of our study was to evaluate Doppler renal blood flow velocity in asphyxiated neonates and to correlate renal function to Doppler findings. Doppler renal blood flow velocity was evaluated in 23 severely asphyxiated neonates born at a gestational age > 32 weeks and compared to our standard Doppler data ob...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s004310050905
更新日期:1998-08-01 00:00:00
abstract::Chylothorax is defined as an effusion of lymph in the pleural cavity. In the neonate both congenital and traumatic (iatrogenic) forms exist. Birth asphyxia and respiratory insufficiency are major symptoms of congenital chylothorax, requiring resuscitation and artificial ventilation. Antenatal diagnosis by ultrasound a...
journal_title:European journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02072505
更新日期:1993-01-01 00:00:00
abstract::Proper nutrition throughout childhood and adolescence is crucial for normal bone development. We investigated whether adherence to Christian Orthodox Church fasting is characterized by periodic avoidance of animal foods (including dairy products), since childhood affects stature or bone health in young adults. This cr...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-019-03542-1
更新日期:2020-04-01 00:00:00
abstract::Perinatal transmission remains the main cause of HIV infection in the pediatric population. Treatment of HIV-infected children has become less of a problem in resource-rich countries with a remarkable decrease of perinatal infections, resulting in an effective prevention of mother-to-child transmission and antiretrovi...
journal_title:European journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s00431-008-0914-8
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abstract::Two girls aged 6 and 10 years treated with anticonvulsants developed nystagmus and ataxia. The peak plasma concentrations of phenytoin were 42.6 and 46.6 microgram/ml, respectively, compatible with phenytoin toxicity. The decline in plasma phenytoin levels did not fit first order kinetics, but followed Michaelis-Mente...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00445896
更新日期:1980-10-01 00:00:00
abstract::We evaluated chronic kidney disease (CKD) (proteinuria or estimated glomerular filtration rate < 60 mL/min/1.73 m2) or hypertension prevalence in 110 children with juvenile idiopathic arthritis (JIA). CKD and hypertension were clustered under the umbrella term of "renal injury". Median age at the last visit was 14 yea...
journal_title:European journal of pediatrics
pub_type: 杂志文章
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journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-005-0002-2
更新日期:2006-02-01 00:00:00
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journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00441406
更新日期:1988-12-01 00:00:00
abstract::Plasma vitamin E levels were determined serially in preterm infants surviving respiratory distress syndrome (RDS) and in premature infants without RDS (control). Vitamin E intakes of the RDS and control infant group were not significantly different. The results of the study show that preterm infants surviving RDS have...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00446056
更新日期:1986-08-01 00:00:00
abstract::Within a 2-year period, from March 1974 until May 1976 10 patients with anorexia nervosa were seen at the children's university hospitals of München (2 patients) and Giessen (8 patients). The patients were 10-16 years old, with one exception all girls, and had the typical cachexia, hypothermia, bradycardia, gray, hair...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00452416
更新日期:1976-12-09 00:00:00
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journal_title:European journal of pediatrics
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journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01954125
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journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00442334
更新日期:1982-02-01 00:00:00
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journal_title:European journal of pediatrics
pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
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journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00481506
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abstract::Cerebral blood flow velocities (CBFV) were measured by the pulsed Doppler method in 41 infants of smoking mothers and in 59 apparently healthy control infants. Although gestational age, birth weight, and systolic blood pressure were lower in infants exposed to tobacco smoke prenatally, systolic (65 +/- 11 vs. 47 +/- 1...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01956151
更新日期:1993-03-01 00:00:00
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journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s004310050730
更新日期:1997-11-01 00:00:00
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journal_title:European journal of pediatrics
pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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journal_title:European journal of pediatrics
pub_type: 杂志文章
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更新日期:2010-10-01 00:00:00
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journal_title:European journal of pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01955273
更新日期:1996-05-01 00:00:00
abstract:UNLABELLED:The use of cannabis as both a therapeutic agent and recreational drug is common, and its availability is increasing as a result of legalization in many countries. Among older children, the manifestations of cannabis intoxication are numerous and include both neurological and systemic manifestations that are ...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-015-2639-9
更新日期:2016-03-01 00:00:00