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Increased cerebral blood flow velocities in newborn infants of smoking mothers.

Abstract：

:Cerebral blood flow velocities (CBFV) were measured by the pulsed Doppler method in 41 infants of smoking mothers and in 59 apparently healthy control infants. Although gestational age, birth weight, and systolic blood pressure were lower in infants exposed to tobacco smoke prenatally, systolic (65 +/- 11 vs. 47 +/- 12 cm/s, mean +/- SD; P < 0.001), mean (36 +/- 6 vs. 25 +/- 6 cm/s; P < 0.001), and diastolic (17 +/- 4 vs 13 +/- 4 cm/s; P < 0.001) CBFVs in the anterior cerebral artery were significantly higher when compared to control infants. Similar differences were seen in the internal carotid and in the basilar arteries. Multiple regression analysis did not reveal differences other than maternal smoking to explain these observations. We conclude that prenatal tobacco smoke exposure is related to increased CBFVs in newborn infants. Further studies should determine whether this relation is not only statistical but causal and whether increased CBFVs are an indicator of prolonged effects of prenatal tobacco smoke exposure.

journal_name

Eur J Pediatr

journal_title

European journal of pediatrics

authors

Abdul-Khaliq H,Segerer H,Luck W,Obladen M

doi

10.1007/BF01956151

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

232-5

issue

3

eissn

0340-6199

issn

1432-1076

journal_volume

152

pub_type

杂志文章

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