Severe anemia due to transient pure red cell aplasia in early childhood. Arrest at the level of the committed stem cells?

Abstract:

:Five patients, 11 months to 3 4/12 years old with severe normochromic, normocytis anemia and reticulocytopenia are reported. At the height of erythropoietic arrest when erythroid precursor cells were completely absent, undifferentiated stem cells (transitional cells), accumulated in the bone marrow. They disappeared again upon spontaneous resumption of erythropoiesis. We suggest that the erythropoietic arrest had occurred at the level of the hematopoietic stem cell. All patients recovered within 1 week of diagnosis. No steroid therapy was given. Failure to recognize this clinical entity leads to unnecessary diagnostic and therapeutic procedures including the transfusion of blood.

journal_name

Eur J Pediatr

authors

Tillmann W,Prindull G,Schröter W

doi

10.1007/BF00497680

subject

Has Abstract

pub_date

1976-08-16 00:00:00

pages

51-8

issue

1

eissn

0340-6199

issn

1432-1076

journal_volume

123

pub_type

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