Delayed cord clamping in Rh-alloimmunised infants: a randomised controlled trial.

Abstract:

:Despite advancement in medical care, Rh alloimmunisation remains a major cause of neonatal hyperbilirubinaemia, neuro-morbidity, and late-onset anaemia. Delayed cord clamping (DCC), a standard care now-a-days, is yet not performed in Rh-alloimmunised infants due to paucity of evidence. Hence, we randomised these infants of 28- to 41-week gestation to delayed cord clamping (N = 36) or early cord clamping (N = 34) groups. The primary outcome variable was venous packed cell volume (PCV) at 2 h of birth. The secondary outcomes were incidence of double volume exchange transfusion (DVET) and partial exchange transfusion (PET), duration of phototherapy (PT), functional echocardiography (parameters measured: superior vena cava flow, M-mode fractional shortening, left ventricular output, myocardial perfusion index, and inferior vena cava collapsibility) during hospital stay, and blood transfusion (BT) until 14 weeks of life. Neonates were managed as per unit protocol. The baseline characteristics of enrolled infants were comparable between the groups. The median (IQR) gestation and mean (SD) birth weight of enrolled infants were 35 (33-37) weeks and 2440 (542) g, respectively. The DCC group had a higher mean PCV at 2 h of life (48.4 ± 9.2 vs. 43.5 ± 8.7, mean difference 4.9% (95% CI 0.6-9.1), p = 0.03). However, incidence of DVET and PET, duration of PT, echocardiography parameters, and BT until 14 weeks of postnatal age were similar between the groups.Conclusion: DCC in Rh-alloimmunised infants improved PCV at 2 h of age without significant adverse effects.Trial registration: Clinical Trial Registry of India (CTRI), Ref/2016/11/012572 http://ctri.nic.in/Clinicaltrials, date of trial registration 19.12.2016, date of first patient enrolment 1 January 2017.What is Known:•Delayed cord clamping improves haematocrit, results in better haemodynamic stability, and decreases the need of transfusion in early infancy.•However, due to lack of evidence, potential risk of hyperbilirubinaemia, and exacerbation of anaemia (following delayed cord clamping), early cord clamping is the usual norm in Rh-alloimmunised infantsinfants.What is New:•Delayed cord clamping in Rh-alloimmunised infants improves haematocrit at 2 h of life without any increase in incidence of serious adverse effects.

journal_name

Eur J Pediatr

authors

Sahoo T,Thukral A,Sankar MJ,Gupta SK,Agarwal R,Deorari AK,Paul VK

doi

10.1007/s00431-020-03578-8

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

881-889

issue

6

eissn

0340-6199

issn

1432-1076

pii

10.1007/s00431-020-03578-8

journal_volume

179

pub_type

杂志文章
  • Meal-induced thermogenesis in obese children with or without familial history of obesity.

    abstract::Resting metabolic rate (RMR) and the thermic effect of a meal (TEM) were measured in a group of 26 prepubertal children divided into three groups: (1) children with both parents obese (n = 8, group OB2); (2) children with no obese parents and without familial history of obesity (n = 8, OB0); and (3) normal body weight...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02072489

    authors: Maffeis C,Schutz Y,Zoccante L,Pinelli L

    更新日期:1993-02-01 00:00:00

  • The value of MRI in diagnosing vascular abnormalities causing stridor.

    abstract:UNLABELLED:In a 2 year period seven patients who presented with stridor, without respiratory compromise, and three patients without obstructive symptoms were prospectively selected, and underwent MRI. In eight patients with a vascular ring and a pulmonary sling, MRI delineated the vascular abnormality and normal great ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s004310050651

    authors: Beekman RP,Beek FJ,Hazekamp MG,Meijboom EJ

    更新日期:1997-07-01 00:00:00

  • Chronic granulomatous disease of childhood: gastric manifestation and response to salazosulfapyridine therapy.

    abstract::The case history of a 10-year-old boy with chronic granulomatous disease (CGD) and gastric obstruction is presented. First abdominal symptoms occurred at 4 years of age when antral narrowing was detected. Due to unresponsiveness to antibiotic and steroid treatment, salazosulfapyridine therapy was initiated. Objective ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02024330

    authors: Stopyrowa J,Fyderek K,Sikorska B,Kowalczyk D,Zembala M

    更新日期:1989-10-01 00:00:00

  • Late-onset sepsis due to urinary tract infection in very preterm neonates is not uncommon.

    abstract::Urinary tract infection (UTI) is a common cause of sepsis in infants. Premature infants hospitalized at a neonatal intensive care unit often have risk factors for infection. In this group, the risk of UTI is not clearly known, and guidelines for urine analysis are not unanimous. We aimed to identify the risk of UTI in...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-017-3030-9

    authors: Mohseny AB,van Velze V,Steggerda SJ,Smits-Wintjens VEHJ,Bekker V,Lopriore E

    更新日期:2018-01-01 00:00:00

  • Plasma fibronectin concentrations in healthy newborns and in children.

    abstract::Plasma fibronectin (FN) concentrations were measured by an immunonephelometric method in cord blood from 76 healthy newborns (45 full term and 31 preterm), in 181 healthy children, from 1 month-15 years old, divided by age into seven groups and in 81 control adults. FN levels in newborns were 35% of those of adults. T...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00442615

    authors: Valletta EA,Bonazzi L,Zuanazzi R,Del Col G,Andreoli A,Stocchero L,Boner AL

    更新日期:1988-01-01 00:00:00

  • Studies of malformation syndromes of man XXXXIIB: mother and son affected with the ulnar-mammary syndrome type Pallister.

    abstract::We report mother and son with the ulnar-mammary syndrome type Pallister: both had postaxial polydactyly in one upper limb and absence or hypoplasia of the axillary apocrine glands bilaterally. The mother had total lack of the mammary gland tissue and absence of one kidney. Her son also had unilateral oligodactyly, an ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00444644

    authors: Gonzalez CH,Herrmann J,Opitz JM

    更新日期:1976-11-03 00:00:00

  • The 'Motorik-Modul' (MoMo): physical fitness and physical activity in German children and adolescents.

    abstract:OBJECTIVES:The aim of the 'Motorik-Modul' (MoMo Basiserhebung, www.motorik-modul.de ) was to establish prevalence measurements on physical fitness and physical activity in German children and adolescents and to identify differences between age groups and genders. A total of 4,529 children and adolescents between the ag...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-010-1391-4

    authors: Woll A,Kurth BM,Opper E,Worth A,Bös K

    更新日期:2011-09-01 00:00:00

  • Obstructive endocarditis in an immunodeficient infant.

    abstract::We report the case of 5-week-old male infant who presented as a 'near miss cot death'. He had the immunodeficient syndrome of defective neutrophil mobility and delayed umbilical cord separation. He was shown to have staphylococcal endocarditis with a large vegetation on the mitral valve, and acute obstruction of the m...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02429063

    authors: Walters MD,Deanfield JE,Robinson PJ,Matthew DJ

    更新日期:1986-12-01 00:00:00

  • Population pharmacokinetics of doxapram in low-birth-weight Japanese infants with apnea.

    abstract:UNLABELLED:This study aimed to determine the population pharmacokinetics of doxapram in low-birth-weight (LBW) infants. A total of 92 serum concentration measurements that were obtained from 34 Japanese neonates were analyzed using nonlinear mixed-effect modeling (NONMEM). Estimates generated by NONMEM indicated that c...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00431-014-2416-1

    authors: Ogawa Y,Irikura M,Kobaru Y,Tomiyasu M,Kochiyama Y,Uriu M,Ishitsuka Y,Kondo Y,Yukawa E,Kamada N,Ohno H,Yamazaki T,Irie T

    更新日期:2015-04-01 00:00:00

  • Demography of adolescent health care delivery and training in Europe.

    abstract:BACKGROUND:We aimed to determine the status of and factors associated with adolescent health care delivery and training in Europe on behalf of the European Paediatric Association-UNEPSA. MATERIALS AND METHODS:A questionnaire was mailed to the presidents of 48 national paediatric societies in Europe. For statistical an...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-008-0759-1

    authors: Ercan O,Alikasifoglu M,Erginoz E,Janda J,Kabicek P,Rubino A,Constantopoulos A,Ilter O,Vural M

    更新日期:2009-04-01 00:00:00

  • Skinfold measurements in children with cystic fibrosis: monitoring fat-free mass and exercise effects.

    abstract:UNLABELLED:Monitoring fat free mass (FFM), an indicator of nutritional status and a predictor of exercise performance in children, is particularly important in patients with cystic fibrosis (CF). We assessed validity of the skinfold method for measuring FFM, and its changes with exercise training, in children with CF. ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s004310051209

    authors: de Meer K,Gulmans VA,Westerterp KR,Houwen RH,Berger R

    更新日期:1999-10-01 00:00:00

  • Hypothalamic adipic hypernatraemia syndrome with normal osmoregulation of vasopressin.

    abstract:UNLABELLED:Adipsic hypernatraemia is an uncommon disorder in childhood caused by a defect in the osmoregulation of thirst, leading to impairment of water homeostasis and chronic hyperosmolality of body fluids. Adipsia is often associated with an abnormality in osmoregulated vasopressin secretion due to the close proxim...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-004-1495-9

    authors: López-Capapé M,Golmayo L,Lorenzo G,Gallego N,Barrio R

    更新日期:2004-10-01 00:00:00

  • Intestinal IgA deposition in Henoch-Schönlein purpura with severe gastro-intestinal manifestations.

    abstract:UNLABELLED:In patients with Henoch-Schönlein purpura (HSP) presenting with severe gastro-intestinal (GI) symptoms, IgA deposition was studied in endoscopically obtained mucosal biopsies. A total number of 11 patients (male, 7; female, 4) were enrolled in this study; 7 patients underwent upper GI endoscopy and biopsy 1 ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02075757

    authors: Kato S,Ebina K,Naganuma H,Sato S,Maisawa S,Nakagawa H

    更新日期:1996-02-01 00:00:00

  • Growth response to growth hormone therapy following craniospinal irradiation.

    abstract::Nineteen (12 male, 7 female) children, who have received craniospinal irradiation for the treatment of a brain tumour distant from the hypothalamic-pituitary axis, resulting in growth hormone (GH) deficiency (CS-PRGHD), have been treated with GH. Eight have completed growth. Comparison has been made with the growth of...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00442471

    authors: Clayton PE,Shalet SM,Price DA

    更新日期:1988-08-01 00:00:00

  • EPONYM. Sweet syndrome.

    abstract::Sweet syndrome, also referred to as acute febrile neutrophilic dermatosis, is characterized by tender, red inflammatory nodules or papules that occur in association with infection, malignancy, connective tissue disease, or following exposure to certain drugs. Although drug-induced Sweet syndrome is rare, granulocyte c...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00431-010-1201-z

    authors: Kim MJ,Choe YH

    更新日期:2010-12-01 00:00:00

  • Iodine deficiency during infancy and early childhood in Belgium: does it pose a risk to brain development?

    abstract::Iodine deficiency is well documented in Belgium in adults including pregnant women, adolescents, schoolchildren, and neonates, but no data are available in the age group 6 months-3 years. We investigated the status of iodine nutrition in 111 healthy subjects in this age group in an attempt to evaluate the risk of brai...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s004310000707

    authors: Delange F,Wolff P,Gnat D,Dramaix M,Pilchen M,Vertongen F

    更新日期:2001-04-01 00:00:00

  • Mother-to-child transmission of human immunodeficiency virus type 1: influence of parity and mode of delivery. Paediatric AIDS Group of Switzerland.

    abstract:UNLABELLED:In a national prospective study of risk factors for mother-to-child transmission of human immunodeficiency virus (HIV), 316 children of HIV-positive mothers were followed up for at least 6 months. Infection status was determined in 254 of them and 46 were found to be infected giving a transmission rate of 18...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02074831

    authors: Kind C

    更新日期:1995-07-01 00:00:00

  • Hemidystonia secondary to acquired toxoplasmosis in a non-immunodeficient patient.

    abstract::We discuss the unusual presentation of acquired toxoplasmosis in a girl with severe and transient hemidystonia as a unique symptom. Serum titres of anti-toxoplasma antibodies increased whereas no specific antibody response in the CSF was observed. While symptomatic drugs were inefficacious, specific anti-toxoplasmosis...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01954489

    authors: Micheli R,Perini A,Duse M

    更新日期:1994-10-01 00:00:00

  • The complement component C4 in sudden infant death.

    abstract:UNLABELLED:The aim of the present study was to compare partial deletions of the complement C4 gene in victims of totally unexplained sudden infant death (SID) (n = 89) and borderline SID (n = 15) with and without slight infections prior to death, in cases of infectious death (n = 19), and in living infants with and wit...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s004310051051

    authors: Opdal SH,Vege A,Stave AK,Rognum TO

    更新日期:1999-03-01 00:00:00

  • Increased serum granulocyte colony-stimulating factor correlates with coronary artery dilatation in Kawasaki disease.

    abstract:UNLABELLED:In acute-phase Kawasaki disease, neutrophils cause injury to the coronary arterial endothelium through the production of elastase. Previous research has demonstrated the modulation of neutrophil function and kinetics, such as development and maturation, by granulocyte colony-stimulating factor (G-CSF). To ex...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-002-1018-5

    authors: Samada K,Igarashi H,Shiraishi H,Hatake K,Momoi MY

    更新日期:2002-10-01 00:00:00

  • Discolored leg syndrome after vaccination--descriptive epidemiology.

    abstract::Discoloration of the leg following vaccination is a relatively unknown entity. We carried out a study of discolored leg syndrome (DLS) during a 10-year consecutive period with the objective of characterizing DLS in infants following vaccination received in the Dutch National Vaccination Program as well as its occurren...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-008-0707-0

    authors: Kemmeren JM,Vermeer-de Bondt PE,van der Maas NA

    更新日期:2009-01-01 00:00:00

  • [On the validity of W170 as a measure of physical performance capacity in the assessment of children with heart disease (author's transl)].

    abstract::W170, i.e., the work rate at a heart frequency of 170 beats per minute, and maximal oxygen uptake were determined in one performance in 20 boys and 23 girls from 6 to 16 years of age on a bicycle ergometer. The results were related to normal values according to age and height. In different age and sex groups correlati...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00463741

    authors: Mocellin R,Bastanier C

    更新日期:1976-06-08 00:00:00

  • Prolonged follow up of seven patients affected by hepatosplenic granulomata due to cat-scratch disease.

    abstract::This study is a retrospective analysis of seven patients with hypoechogenic lesions in the liver and/or spleen due to Bartonella henselae, who were followed from 1998 through to 2005 by the Department of Pediatrics, Turin University. In addition to showing constitutional symptoms, four children had skin lesions sugges...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-007-0500-5

    authors: Scolfaro C,Leunga GG,Bezzio S,Chiapello N,Riva C,Balbo L,Bertaina C,Tovo PA

    更新日期:2008-04-01 00:00:00

  • New therapies for acute RSV infections: where are we?

    abstract::Respiratory syncytial virus (RSV) infection is one of the main causes of infant hospitalization and mortality. The single-stranded RNA virus codes for 11 proteins of which the F protein, a surface epitope responsible for RSV fusion, is the most targeted for developing antiviral medicines and vaccines. The peak of symp...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00431-018-03310-7

    authors: Xing Y,Proesmans M

    更新日期:2019-02-01 00:00:00

  • Desquamative interstitial pneumonitis and alveolar lipoproteinosis: diagnostic difficulties and therapy problems with an infant.

    abstract::A desquamative, interstitial pneumonitis was diagnosed histologically in a 9-month-old boy who first became ill at the age of 5 weeks. The desquamative interstitial pneumonitis was associated with an acquired cytomegalovirus (CMV) infection. Despite treatment with corticoids, acyclovir and artificial ventilation, the ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02429072

    authors: Schneider K,Brünstler I,Vogel H,Fendel H,Remberger K

    更新日期:1986-12-01 00:00:00

  • Anti-glomerular basement membrane antibody-mediated glomerulonephritis due to glue sniffing.

    abstract::A 16-year-old girl developed rapidly progressive glomerulonephritis and renal failure. The disease was associated with high titres of antiglomerular basement membrane antibodies in serum, linear deposits of immunoglobulin G and diffuse epithelial crescents on renal biopsy. Past history revealed heavy smoking and delib...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00716479

    authors: Bonzel KE,Müller-Wiefel DE,Ruder H,Wingen AM,Waldherr R,Weber M

    更新日期:1987-05-01 00:00:00

  • Successful remission induced by plasma exchange combined with leukocytapheresis against refractory systemic juvenile idiopathic arthritis.

    abstract::Systemic juvenile idiopathic arthritis (sJIA) is an inflammatory cytokine-related disorder associated with overproduction of interleukin (IL)-6, IL-1β, and IL-18. Macrophage activation syndrome (MAS) is a critical and lethal complication of sJIA. Therefore, prompt induction of remission in the active phase of sJIA is ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-013-2093-5

    authors: Miyazono A,Abe J,Ogura M,Sato M,Fujimaru T,Kamei K,Ito S

    更新日期:2014-12-01 00:00:00

  • Epilepsy: knowledge and attitudes of physiotherapists, occupational therapists, and speech therapists.

    abstract::Physiotherapists, occupational therapists, and speech therapists play a key role in the treatment of children with epilepsy. We performed a survey of therapists' knowledge of and attitudes towards epilepsy in two regions of Germany, the city of Leipzig and the rural district of Zwickau. Therapists of 29/68 (43%) outpa...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-019-03437-1

    authors: Hackel K,Neininger MP,Kiess W,Bertsche T,Bertsche A

    更新日期:2019-10-01 00:00:00

  • The spectrum of care for pediatric refugees and asylum seekers at a tertiary health care facility in Switzerland in 2015.

    abstract::The aim of this retrospective study was to describe the epidemiology and spectrum of infections of admitted pediatric refugees and asylum seekers in a tertiary referral hospital in a high-income country in Europe. We identified recent refugees and asylum seekers < 18 years of age admitted to the University Children's ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-017-3014-9

    authors: Pohl C,Mack I,Schmitz T,Ritz N

    更新日期:2017-12-01 00:00:00

  • Oral vitamin A supplementation in very low birth weight neonates: a randomized controlled trial.

    abstract::This randomized double-blind placebo-controlled trial evaluated the effects of early postnatal oral vitamin A supplementation (VAS) in 196 inborn very-low birth weight (VLBW) infants requiring respiratory support at 24 h of age. Eligible infants were randomized to receive aqueous syrup of vitamin A (10,000 IU of retin...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00431-019-03412-w

    authors: Basu S,Khanna P,Srivastava R,Kumar A

    更新日期:2019-08-01 00:00:00