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Chlorambucil central nervous toxicity: a significant side effect of chlorambucil therapy in childhood nephrotic syndrome.

Abstract：

:Chlorambucil (CHL) was used in combination with prednisolone in the treatment of nine children with frequently relapsing nephrotic syndrome. Serial electroencephalograms were obtained to evaluate CHL central nervous toxicity, before, during and after treatment with this agent. EEG abnormalities were observed in two of the nine children during chlorambucil therapy. EEG changes were diffuse spike and wave complexes and disappeared after discontinuation of therapy. There were no other neurological abnormalities and more particularly, no seizures or myocloni were observed. According to the literature, chlorambucil central nervous toxicity is found almost exclusively in childhood nephrotic syndrome. Strict neurological supervision of patients treated with chlorambucil is recommended.

journal_name

Eur J Pediatr

journal_title

European journal of pediatrics

authors

Ichida F,Konishi T,Asada R,Yamatani M,Konda M,Tani M,Tanizawa T,Suzuki Y,Okada T,Kyotani S

doi

10.1007/BF00451963

subject

Has Abstract,Author List Incomplete

pub_date

1985-09-01 00:00:00

pages

283-6

issue

3

eissn

0340-6199

issn

1432-1076

journal_volume

144

pub_type

杂志文章

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