On the influence of age on immunity in Down's syndrome.

Abstract:

:In 23 subjects of different ages with Down's syndrome a number of parameters of non-specific defense of humoral and cellular immunity were investigated. While in all age groups complement factors C3, C4 and C5 as well as phagocytosis and NBT indices were in the normal range, a dysgammaglobulinaemia increasing with age with a hyperglobulinaemia of the IgG, IgA and IgD types was found, sparing immunoglobulins IgM and IgE. In addition the transformation capacity of peripheral blood lymphocytes decreased with age. This is understood as the consequence of premature aging of the thymus-dependent immune system.

journal_name

Eur J Pediatr

authors

Seger R,Buchinger G,Ströder J

doi

10.1007/BF00477543

keywords:

subject

Has Abstract

pub_date

1977-01-26 00:00:00

pages

77-87

issue

2

eissn

0340-6199

issn

1432-1076

journal_volume

124

pub_type

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