Effectiveness of pandemic influenza A/H1N1 vaccine for prevention of otitis media in children.

Abstract:

UNLABELLED:Our aim was to evaluate effectiveness of pandemic influenza A/H1N1 vaccine in preventing acute otitis media (AOM) and/or otitis media with effusion (OME), in a randomized, prospective and single-blind study conducted in the children aged of 6-60 months. This study was done between December 1, 2009 and April 30, 2010 during the pandemia between June 2009 and May 2010. On the healthy children, vaccinated against pandemic influenza A/H1N1 and age-matched unvaccinated controls, the rate of AOM, OME, and any otitis media (OM) attack (sum of AOM and OME attacks) confirmed by otoscopic and tympanometric examination, and their associations with risk factors were looked for. Otoscopic and tympanometric evaluation was done twice within the follow-up period of 4-8 weeks. Totally 46 vaccinated and 46 unvaccinated healthy children were enrolled. No difference in rates of AOM, OME, or OM was found between vaccinated and unvaccinated children. But logistic regression analysis revealed that unvaccinated children had 2.9-folds more risk for OME and OM, but not for AOM. Further, male gender and bottle feeding and/or using pacifier revealed significant relationships with AOM. CONCLUSION:We conclude that pandemic influenza A/H1N1 vaccine prevented OME rather than AOM attacks in children with 6-60 months of age.

journal_name

Eur J Pediatr

authors

Cuhaci Çakir B,Beyazova U,Kemaloğlu YK,Özkan S,Gündüz B,Özdek A

doi

10.1007/s00431-012-1797-2

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

1667-71

issue

11

eissn

0340-6199

issn

1432-1076

journal_volume

171

pub_type

杂志文章,随机对照试验
  • Educational Paper: Aspects of clinical pharmacology in children--pharmacovigilance and safety.

    abstract::Adverse drug reactions (ADRs) are a significant problem in children, affecting one in ten children in hospital. Within the community, one in 500 children will experience an adverse drug reaction each year. Pharmacovigilance has been useful in detecting suspected ADRs. However, most ADRs are unreported and often not su...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00431-012-1871-9

    authors: Choonara I

    更新日期:2013-05-01 00:00:00

  • Postnatal course of plasma levels of adrenocortical steroids in premature infants with and without NaCl supplementation.

    abstract::To assess the adrenocortical response of premature infants to alterations in sodium balance, the postnatal course of plasma progesterone, 11-deoxycorticosterone, corticosteronoe, aldosterone, 17-hydroxyprogesterone, 11-deoxycortisol, cortisol and cortisone was compared in healthy premature infants kept on low (1-2 mEq...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00441415

    authors: Sulyok E,Dörr HG,Ertl T,Gyódi G

    更新日期:1988-12-01 00:00:00

  • Central precocious puberty and growth hormone deficiency in a boy with Prader-Willi syndrome.

    abstract::In Prader-Willi syndrome (PWS) hypothalamic dysfunction is the cause of hormonal disturbances, such as growth hormone deficiency (GHD), hypogonadism, and delayed or incomplete puberty. Only a few cases of central precocious puberty (CPP) have been reported. We describe an 8.8-year-old PWS boy, with microdeletion of ch...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-008-0679-0

    authors: Crinò A,Di Giorgio G,Schiaffini R,Fierabracci A,Spera S,Maggioni A,Gattinara GC

    更新日期:2008-12-01 00:00:00

  • The effect of L-asparaginase on lipid metabolism during induction chemotherapy of childhood lymphoblastic leukaemia.

    abstract::L-asparaginase is an effective antileukaemic drug and a potent inhibitor of hepatic protein synthesis. Its effect on lipid metabolism was studied in two cohorts of children with ALL, one of whom received L-asparaginase concomitantly with three other drugs (protocol BFM 79). In the second protocol (BFM 83) administrati...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00442614

    authors: Cremer P,Lakomek M,Beck W,Prindull G

    更新日期:1988-01-01 00:00:00

  • Syphilis returns to the suburbs.

    abstract::Congenital syphilis is now rare in Australia, particularly in suburban areas. The disease is both preventable and treatable, however, missed or late diagnosis can lead to catastrophic effects. We report an infant who developed congenital syphilis after multiple opportunities for preventing this condition were missed. ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-005-0050-7

    authors: Hargrove A,Curtis N

    更新日期:2006-05-01 00:00:00

  • Paraneoplastic manifestations in children.

    abstract::Paraneoplastic manifestations are signs and symptoms observed in patients with cancer, distant from the tumour or its metastases and not caused by invasion, obstruction or bulk mass. In children with cancer, paraneoplastic manifestations are rare and distinct from those observed in adults. Knowledge about paraneoplast...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/BF01972883

    authors: de Graaf JH,Tamminga RY,Kamps WA

    更新日期:1994-11-01 00:00:00

  • Vaccination coverage and sociodemographic determinants of measles-mumps-rubella vaccination in three different age groups.

    abstract::WHO-Europe's goal is to eliminate measles and rubella by 2010 which will require a coverage rate of 95% for both MMR-vaccine doses. Belgian recommendations include a first MMR vaccine at 12 months and a second at 10-12 years of age. To survey MMR vaccination coverage, EPI two-stage random cluster samples of 1,500 todd...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-007-0652-3

    authors: Vandermeulen C,Roelants M,Theeten H,Van Damme P,Hoppenbrouwers K

    更新日期:2008-10-01 00:00:00

  • Pseudohyperkalaemia in Kawasaki disease.

    abstract::Pseudohyperkalaemia was observed in 3 of 16 patients with Kawasaki disease showing remarkably increased platelet counts. Their plasma potassium concentration, which is not affected by in vitro coagulation, was in the normal range despite the increased serum level. A significant correlation was observed between the pla...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01957752

    authors: Shimizu T,Yamashiro Y,Yabuta K

    更新日期:1992-07-01 00:00:00

  • Estimation of postoperative fat absorption using the 13C mixed-triglyceride breath test in children with choledochal cyst.

    abstract::No previous studies have focused on postoperative fat malabsorption in children with choledochal cyst (CC) who undergo cyst excision and Roux-en-Y (RY) hepatico-jejunostomy (HJ), a combination of procedures that can lead to the non-physiological mixture of food and bile juice. To examine the effect of RYHJ with cholec...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-008-0703-4

    authors: Suzuki M,Tanaka K,Ohtani K,Kitamura K,Kudo T,Shoji H,Suzuki R,Shimizu T

    更新日期:2009-01-01 00:00:00

  • Lymphocytic hypophysitis presenting with diabetes insipidus in a 14-year-old girl: case report and review of the literature.

    abstract:UNLABELLED:Lymphocytic hypophysitis is a rare disorder predominantly affecting females during the antepartum or postpartum period. It is characterized by destruction and lymphocytic infiltration of the pituitary gland, probably by an autoimmune process, leading to a pituitary mass lesion and/or various degrees of hypop...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s004310050690

    authors: Cemeroglu AP,Blaivas M,Muraszko KM,Robertson PL,Vázquez DM

    更新日期:1997-09-01 00:00:00

  • Beneficial effects of creatine phosphate sodium for the treatment of Henoch-Schönlein purpura in patients with early renal damage detected using urinary kidney injury molecule-1 levels.

    abstract:UNLABELLED:Henoch-Schönlein purpura (HSP) is a small-vessel disease in children that is often accompanied by kidney damage. Despite many efforts to improve the early assessment of renal injury in HSP patients, effective markers are still lacking. In recent years, the relationship between kidney injury molecule-1 (KIM-1...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-015-2601-x

    authors: Zhang J,Zeng H,Wang N,Tian X,Dou W,Shi P

    更新日期:2016-01-01 00:00:00

  • Inpatient treatment of obese children: a multicomponent programme without stringent calorie restriction.

    abstract:UNLABELLED:This prospective clinical case-control study describes the effect of an inpatient multicomponent treatment programme for obese children and adolescents on their weight and psychological well being. We studied 38 patients and 38 controls on the waiting list, matched for age and gender, referred because of obe...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-003-1155-5

    authors: Braet C,Tanghe A,Bode PD,Franckx H,Winckel MV

    更新日期:2003-06-01 00:00:00

  • Lamivudine and high-dose interferon alpha 2a combination treatment in naïve HBeAg-positive immunoactive chronic hepatitis B in children: an East Mediterranean center's experience.

    abstract::Chronic hepatitis B virus infection is among the most common causes of chronic liver disease in children. The aim of this study was to document prospectively our experiences related to lamivudine and high-dose interferon-alpha2a combination in naïve, e antigen positive, chronic hepatitis B virus infection treatment in...

    journal_title:European journal of pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00431-006-0220-2

    authors: Yilmaz A,Akcam M,Gelen T,Artan R

    更新日期:2007-03-01 00:00:00

  • Intestinal IgA deposition in Henoch-Schönlein purpura with severe gastro-intestinal manifestations.

    abstract:UNLABELLED:In patients with Henoch-Schönlein purpura (HSP) presenting with severe gastro-intestinal (GI) symptoms, IgA deposition was studied in endoscopically obtained mucosal biopsies. A total number of 11 patients (male, 7; female, 4) were enrolled in this study; 7 patients underwent upper GI endoscopy and biopsy 1 ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02075757

    authors: Kato S,Ebina K,Naganuma H,Sato S,Maisawa S,Nakagawa H

    更新日期:1996-02-01 00:00:00

  • Heme oxygenase-1 expression in premature and mature neonates during the first week of life.

    abstract::Newborns are exposed to mechanical and oxidative stress during labor and to relative hyperoxia thereafter during the course of adaptation to the extrauterine conditions. Part of the adaptation mechanism is the rapid degradation of fetal hemoglobin and the oxidation of its heme moiety by heme oxygenases (HOs). Heme oxy...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-006-0375-x

    authors: Maróti Z,Katona M,Orvos H,Németh I,Farkas I,Túri S

    更新日期:2007-10-01 00:00:00

  • 3-Methylglutaconic and 3-methylglutaric aciduria in a patient with suspected 3-methylglutaconyl-CoA hydratase deficiency.

    abstract::A girl suffering from marked muscular hypotonia, severe statomotor and mental retardation, bilateral optic atrophy with chorioretinal degeneration, convulsions and a moderate compensated metabolic acidosis is described. Screening for metabolic disorders revealed massive 3-methylglutaconic with 3-methylglutaric aciduri...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00442306

    authors: Lehnert W,Scharf J,Wendel U

    更新日期:1985-03-01 00:00:00

  • Neonatal anthropometrics and correlation to childhood obesity--data from the Danish Children's Obesity Clinic.

    abstract:UNLABELLED:Recent evidence has demonstrated the prenatal initiation of childhood obesity as epidemiological studies and animal studies have illustrated the effect of the intrauterine milieu for subsequent development of childhood obesity. This study investigates the relationship between severe childhood obesity and the...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-013-1949-z

    authors: Lausten-Thomsen U,Bille DS,Nässlund I,Folskov L,Larsen T,Holm JC

    更新日期:2013-06-01 00:00:00

  • Long-term clinical effectiveness of an acellular pertussis component vaccine and a whole cell pertussis component vaccine.

    abstract:UNLABELLED:The objective of this open study was to monitor the long-term effectiveness of the Lederle-Takeda diphtheria and tetanus toxoids and acellular pertussis antigen(s) (DTaP) vaccine and the Wyeth-Lederle diphtheria and tetanus toxoids and pertussis whole cell (DTP) vaccine in children who had received four dose...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-001-0893-5

    authors: Lugauer S,Heininger U,Cherry JD,Stehr K

    更新日期:2002-03-01 00:00:00

  • Persistent low plasma vitamin E levels in premature infants surviving respiratory distress syndrome.

    abstract::Plasma vitamin E levels were determined serially in preterm infants surviving respiratory distress syndrome (RDS) and in premature infants without RDS (control). Vitamin E intakes of the RDS and control infant group were not significantly different. The results of the study show that preterm infants surviving RDS have...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00446056

    authors: Huijbers WA,Schrijver J,Speek AJ,Deelstra BA,Okken A

    更新日期:1986-08-01 00:00:00

  • Latent chronic cholangitis in congenital hepatic fibrosis.

    abstract::In a five-year-old girl with congenital hepatic fibrosis raised erythrocyte sedimentation rate and serum gammaglobulins were noted for 3 years. Needle liver biopsy showed histological features of cholangitis and Klebsiella oxytoca was cultured from a liver biopsy specimen. Antibiotic treatment resulted in normalizatio...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01377359

    authors: Alvarez F,Hadchouel M,Bernard O

    更新日期:1982-11-01 00:00:00

  • Transient lactic acidosis and hyperalaninaemia associated with neonatal hyperinsulinaemic hypoglycaemia: the effects of dichloroacetate (DCA).

    abstract::Soon after birth a 36-week-gestational age, appropriate for dates, newborn infant developed hyperinsulinaemic hypoglycaemia which responded to diazoxide and glucose infusion. While normoglycaemic, he became increasingly ill with high lactate, pyruvate, and alanine levels. Provocation tests suggested a defect in lactat...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00496802

    authors: Aynsley-Green A,Weindling AM,Soltész G,Jenkins PA

    更新日期:1983-12-01 00:00:00

  • Necrotizing enterocolitis beyond the neonatal period.

    abstract::Necrotizing enterocolitis (NEC) is usually considered to be a neonatal disease, and is rarely described beyond the newborn period. During the last 15 years, 19 infants from the Negev region, Israel, with NEC were beyond the neonatal age group (range = 34-616 days, median = 90 days). Of this group only 16% were born pr...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00442592

    authors: Dagan R,Ben-Yacov O,Mares AJ,Moses SW,Bar-Ziv J

    更新日期:1984-04-01 00:00:00

  • Disaster zones-should we be clowning around?

    abstract::Medical clowns have an important role in helping patients cope with their pain and distress. This is especially true in the pediatric population. However, their activity in a disaster area is unheard of. Following the Nepal earthquake in 2015, the Israeli field hospital set up in Kathmandu, Nepal was joined by five vo...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-017-3018-5

    authors: Ilan U,Davidov A,Mendlovic J,Weiser G

    更新日期:2018-02-01 00:00:00

  • Extensive brown tumors caused by parathyroid adenoma in an adolescent patient.

    abstract::Primary hyperparathyroidism is a rare endocrine disease in children and young adults. The early detection and treatment of primary hyperparathyroidism led to a marked decrease in classical bone and renal manifestations of the disease. Osteitis fibrosa cystica and brown tumors have become extremely rare clinical entiti...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-007-0414-2

    authors: Atabek ME,Pirgon O,Sert A,Esen HH

    更新日期:2008-01-01 00:00:00

  • Absence epilepsy of early childhood--genetic aspects.

    abstract::Clinical and EEG family data of 140 cases with early childhood epilepsy with absences are presented. The aim of the study was to evaluate, whether the occurrence of generalized tonic clonic seizures (GTCS) as a presenting symptom might correlate with family data, i.e. whether there are indications of heterogeneity. On...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01956423

    authors: Doose H

    更新日期:1994-05-01 00:00:00

  • Correlation between pituitary growth hormone reserve and degree of growth failure in children with short stature.

    abstract::The correlation between a releasable pituitary growth hormone (GH) pool and degree of growth failure was examined in 30 children with GH deficiency (group I) and 19 children with normal short stature (group II). Based on the responsiveness of GH to GH-releasing hormone (GHRH), group I, with low GH responses (below 7 n...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00442468

    authors: Kajiwara S,Igarashi N,Imura E,Sato T

    更新日期:1988-08-01 00:00:00

  • Late onset subgaleal hemorrhage infection with Streptococcus pneumoniae?

    abstract::We report a case of an infected subgaleal hematoma caused by an unusual micro-organism in a previously healthy 11-month-old girl. Our patient presented at the emergency department with an increasing scalp swelling for 2 weeks, and culture of the evacuated fluid yielded Streptococcus pneumoniae. Although she was born a...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00431-009-0922-3

    authors: Slap F,Jeurissen A,Van Havenbergh T,Deckers F,Mariën P,Van Mol C

    更新日期:2009-06-01 00:00:00

  • A time for reappraisal of "atypical" hemolytic uremic syndrome: should all patients be treated the same?

    abstract:UNLABELLED:Atypical hemolytic uremic syndrome (HUS) refers to the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury in the absence of Shiga toxin-producing Escherichia coli exposure or Streptococcus pneumoniae infection. Currently, approximately 50 % of the atypical cases have demons...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-012-1763-z

    authors: Ruebner RL,Kaplan BS,Copelovitch L

    更新日期:2012-10-01 00:00:00

  • Preterm or small-for-gestational-age infants. Neurological and behavioural development at the age of 6 years.

    abstract::In 166 full term, small-for-gestational-age (FT-SGA), 53 preterm, appropriate-for-gestational-age (PT-AGA), 27 PT-SGA and 206 FT-AGA infants a neurological examination at the age of 6 years was carried out. Data were collected on behaviour and school achievement. Major and minor neurological abnormalities were more fr...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00441967

    authors: Hadders-Algra M,Huisjes HJ,Touwen BC

    更新日期:1988-06-01 00:00:00

  • A case report of sporadic hemiplegic migraine associated cerebral hypoperfusion: comparison of arterial spin labeling and dynamic susceptibility contrast perfusion MR imaging.

    abstract:UNLABELLED:The pathogenesis of sporadic hemiplegic migraine remains unclear, and perfusion-weighted magnetic resonance imaging (PWI) has been used for characterization of hemodynamic changes in migraine aura. We report a case of sporadic hemiplegic migraine in which magnetic resonance perfusion imaging showed left cere...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-015-2609-2

    authors: Kim S,Kang M,Choi S

    更新日期:2016-02-01 00:00:00