Abstract：
:Co-trimoxazole is an effective antibacterial agent for the prophylaxis of urinary tract infection. Because experimental evidence raises the possibility that high-dose cotrimoxazole might interfere with normal somatic growth, the longitudinal growth and growth velocities were analysed in 114 girls receiving long-term, low-dose prophylactic cotrimoxazole. They were aged 2-12 years at the start of prophylaxis which was given in a daily dose of approximately 10 mg sulphamethoxazole (SMX) and 2 mg trimethoprim (TMP)/kg body weight for at least 6 months and for up to 6 years. There was no significant variation from normal in height or weight attained or in growth velocity overall in 114 girls, 51 of whom had vesico-ureteric reflux (VUR). No difference was found in growth velocity when periods of 6 months on or off prophylactic therapy were compared in 53 girls. Growth did not vary between cohorts of girls receiving co-trimoxazole prophylaxis for 2, 3 or 4 years and growth proceeded normally in the 51 girls with VU reflux. We have not found evidence that long-term, low-dose cotrimoxazole prophylaxis has any adverse effect upon somatic growth in girls with a previous urinary infection with or without vesico-ureteric reflux and who are otherwise healthy.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Smellie JM,Preece MA,Paton AMdoi
10.1007/BF00442669subject
Has Abstractpub_date
1983-09-01 00:00:00pages
301-4issue
4eissn
0340-6199issn
1432-1076journal_volume
140pub_type
杂志文章abstract：UNLABELLED:In a Swiss screening programme for detection of congenital adrenal hyperplasia (CAH), 27 of over 120,000 newborns examined from 1992 to 1994 were further studied because of persistingly high 17 alpha hydroxyprogesterone (17OHP). Out of 27, 11 were later confirmed to have CAH by specific gas chromatography of...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02282880
更新日期：1996-11-01 00:00:00
abstract：UNLABELLED:We describe the case of a boy with steroid sensitive nephrotic syndrome and left pulmonary artery thrombo-embolism. clinical presentation initially suggested sepsis and respiratory signs were minor. Treatment with tissue plasminogen activator infused into the pulmonary artery was successful. CONCLUSION:Pulm...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050684
更新日期：1997-08-01 00:00:00
abstract：:The incidence of urolithiasis in children is increasing. Adequate knowledge of treatment modalities and surgical options is therefore essential for every pediatrician. Surgical approaches to urolithiasis in children continue to evolve with advancements in technology and sophistication of current equipment and techniqu...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-010-1373-6
更新日期：2011-06-01 00:00:00
abstract：:Low body mass index (BMI) z score is commonly used to define undernutrition, but faltering growth allows for a complementary dynamic assessment of nutritional status. We studied the prevalence of undernutrition and faltering growth at admission in the pediatric intensive care (PICU) setting and their impacts on outcom...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章
doi：10.1007/s00431-017-3062-1
更新日期：2018-03-01 00:00:00
abstract：:The new coronavirus disease outbreak in 2019 (COVID-19) represents a dramatic challenge for healthcare systems worldwide. As to viral tropism, lungs are not the only COVID-19 target but also the heart may be involved in a not negligible percentage of the infected patients. Myocarditis-related cardiac dysfunction and p...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03699-0
更新日期：2020-07-01 00:00:00
abstract：UNLABELLED:Extremely immature newborns develop a self-limiting normal anion gap metabolic acidosis in early life. This study examined the natural history of this acidosis in a population of infants of gestation less than 26 weeks in the first 14 days of life. The acidosis was maximal on day 4 with a mean base deficit o...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-014-2364-9
更新日期：2015-01-01 00:00:00
abstract：:An adolescent girl with severe thrombotic thrombocytopenic purpura (TTP) remained in a critical condition after 3 weeks of combined treatment with antiplatelet drugs, plasma infusions and plasma exchange. The introduction of vincristine resulted in gradual improvement and eventual complete remission which lasted for 2...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01957008
更新日期：1994-07-01 00:00:00
abstract：:A 4-month-old infant was admitted to the Pediatric Intensive Care Unit with Pneumococcal meningitis. A few hours after admission he developed intractable convulsions that could not be stopped with phenytoin, phenobarbitone and a continuous drip of diazepam. Thiopentone sodium anaesthesia was induced for 24 h terminati...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441663
更新日期：1983-04-01 00:00:00
abstract：:Piritramide is indicated for treatment of postoperative pain and analgosedation in the intensive care unit (ICU) setting. In an open prospective study the pharmacokinetics of piritramide were investigated in four groups: newborns (NB, age: 1-28 days) (n=8), infants 1 (IF1, age: 2-4 months) (n=7), infants 2 (IF2, age: ...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章
doi：10.1007/s00431-005-0021-z
更新日期：2006-04-01 00:00:00
abstract：:An 8-year-old boy with an hepatic form of Wilson disease was treated with oral zinc sulphate as the primary and sole therapy. After 4 months, liver function had dramatically improved, and the parameters characterizing copper metabolism had also normalized. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441526
更新日期：1989-06-01 00:00:00
abstract：UNLABELLED:Congenital hydrocephalus is a serious condition that can arise from multiple causes. It comprises a diverse group of conditions which result in impaired circulation and absorption of cerebrospinal fluid. Congenital malformations of the central nervous system, infections, haemorrhage, trauma, teratogens and, ...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s004310050830
更新日期：1998-05-01 00:00:00
abstract：UNLABELLED:Monitoring fat free mass (FFM), an indicator of nutritional status and a predictor of exercise performance in children, is particularly important in patients with cystic fibrosis (CF). We assessed validity of the skinfold method for measuring FFM, and its changes with exercise training, in children with CF. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310051209
更新日期：1999-10-01 00:00:00
abstract：:This is a report on two mentally retarded sibs with similar anomalies (sagittal craniosynostosis, complex cardiovascular malformations, mandibular ankylosis) and various dysmorphic features. They could represent a "new" probably monogenic syndrome. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00647293
更新日期：1987-01-01 00:00:00
abstract：:Patients with Turner syndrome (n = 33) were subjected to a sequential oestrogen/gestagen replacement therapy (21 days 2 mg oestradiol valerate plus 0.5 mg norgestrel for 10 days) for 1-4 years. In individuals aged 12-17 years, growth velocities before treatment ranged between 2.9 and 1.9 cm/year and increased to 6.8-3...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00439400
更新日期：1986-09-01 00:00:00
abstract：UNLABELLED:Utilization of complementary and alternative medicine (CAM) among children/adolescents is popular. This review summarizes the international findings for prevalence and predictors of CAM use among children/adolescents. We therefore systematically searched four electronic databases (PubMed, Embase, PsycINFO, A...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-014-2300-z
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:The tuberculin skin test (TST) is the most useful method for the diagnosis of tuberculosis (TB). There is no evidence about the effect of bacillus Calmette-Guerin (BCG) vaccine on the interpretation of TST results. OBJECTIVE:The aim of this study was to evaluate TST results in a population of immigrants and...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-012-1783-8
更新日期：2012-11-01 00:00:00
abstract：UNLABELLED:Human parechoviruses (HPeV) have been recently recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence in infants <1 month in Spain and, secondly, to analyse the clinical and epidemiological characteristics of the infected patien...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/s00431-015-2566-9
更新日期：2015-11-01 00:00:00
abstract：UNLABELLED:In order to determine the response to high-frequency oscillatory ventilation (HFOV), used as an "early rescue" therapy, in a cohort of paediatric patients with acute respiratory distress syndrome (ARDS), a prospective clinical study was performed in a tertiary care paediatric intensive care unit. Ten consecu...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-004-1544-4
更新日期：2005-01-01 00:00:00
abstract：:Before promoting certain types of physical activities, the Health Promotion and Disease Prevention Department of Malta wanted to know whether children knew how to perform them in the first place, and if not, what barriers they had encountered. A cross-sectional, self-reported study involved 11-year-old students (boys ...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/s00431-010-1185-8
更新日期：2010-09-01 00:00:00
abstract：:Autoimmune hepatitis (AIH) is a member of autoimmune diseases family which can increase risk of cardiovascular morbidity and mortality. This study aimed to assess subclinical impact of AIH on global myocardial performance in affected children using Doppler tissue imaging (DTI) and to correlate it with total serum immu...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章
doi：10.1007/s00431-013-2073-9
更新日期：2013-11-01 00:00:00
abstract：:Two unique associations of disease with Escherichia coli O157:H7 are presented. These cases broaden the spectrum of disease associated with this organism which currently includes bloody and non-bloody diarrhoea, haemolytic-uraemic syndrome, and thrombotic thrombocytopenic purpura. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02106287
更新日期：1990-01-01 00:00:00
abstract：:Congenital adrenal hyperplasia (CAH) is an inherited metabolic disease caused by the deficiency of one of the enzymes necessary for cortisol synthesis. With carefully supervised medical treatment, CAH patients have the capacity for normal puberty and fertility. We report on a 12.4-year-old female who, because of the e...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-008-0847-2
更新日期：2009-07-01 00:00:00
abstract：:Since immunological disorders have been demonstrated in patients with Diamond-Blackfan anaemia (DBA), intravenous immunoglobulins (IVIG) were administered to a 14-year-old girl with DBA and congenital malformations, previously treated with corticosteroids and blood transfusions. No therapeutic effect was observed. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01957279
更新日期：1990-08-01 00:00:00
abstract：:In five L-thyroxine-substituted hypothyroid children with partial epilepsy serum total thyroxine (T4) and free T4 (FT4) significantly (P less than 0.01) decreased following 2 months of carbamazepine (CBZ) administration (20 mg/kg per BW per day) from mean (+/- SD) values of 12.7 +/- 1.1 micrograms/dl and 15.5 +/- 1.8 ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441860
更新日期：1986-04-01 00:00:00
abstract：:A 7-year-old girl was admitted with a severe abdominal pain. Abdominal ultrasound and CT revealed a large splenic infarction, leading to the diagnosis of chronic myeloid leukemia. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-012-1675-y
更新日期：2012-07-01 00:00:00
abstract：:Recombinant human erythropoietin was given to eight children and adolescents with stable chronic renal failure in the predialysis state. The hormone was administered subcutaneously, twice weekly for 12 weeks, at a starting dose of 50 U/kg per week. The dosage was adapted every 4th week. Target haemoglobin was 10.5-11....
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01959224
更新日期：1994-02-01 00:00:00
abstract：:Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections and hospitalizations in children aged < 2 years. The aim of this retrospective, single-centre study was to examine the characteristics of patients admitted to a paediatric intensive care unit (PICU) with RSV infection followin...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-010-1376-3
更新日期：2011-07-01 00:00:00
abstract：:An 18-month-old child with partial DiGeorge syndrome developed aplastic anaemia during an acute adenovirus infection. Assessment of the child's immune system revealed T-cell subset abnormalities consistent with DiGeorge syndrome. A possible link between the underlying immune deficiency and the observed complication is...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442482
更新日期：1988-08-01 00:00:00
abstract：UNLABELLED:Coronary artery disease (CAD) is a major cause of death in patients with insulin-dependent diabetes mellitus. Qualitative changes in low density lipoprotein (LDL) and high density lipoprotein (HDL) are thought to be important for evaluating the risk for CAD. In the present study, we evaluated LDL particle si...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050810
更新日期：1998-04-01 00:00:00
abstract：UNLABELLED:A total of 22 Japanese patients with hypophosphatasia were included in a study analysing the relationship between mutations in the tissue-nonspecific alkaline phosphatase (TNSALP) gene and the severity of the phenotype in Japanese patients with hypophosphatasia. The enzymatic activity of some of the identifi...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-004-1612-9
更新日期：2005-05-01 00:00:00
