Abstract：
:Recombinant human erythropoietin was given to eight children and adolescents with stable chronic renal failure in the predialysis state. The hormone was administered subcutaneously, twice weekly for 12 weeks, at a starting dose of 50 U/kg per week. The dosage was adapted every 4th week. Target haemoglobin was 10.5-11.5 g/dl, and the target haematocrit 32%-35%. Baseline haemoglobin levels of 8.20 +/- 0.93 g/dl increased to 9.17 +/- 1.10, 10.38 +/- 1.18 and 11.19 +/- 0.84 g/dl (mean +/- SD) after 4, 8 and 12 weeks respectively. Serum ferritin levels decreased progressively despite iron supplementation. No side-effects were observed: creatinine clearances remained stable, blood pressure did not increase and none of the patients displayed either convulsions or thrombotic features. The study shows that subcutaneous recombinant human erythropoietin is both effective and safe in anaemic children and adolescents with chronic renal insufficiency.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Van Geet C,Van Dyck M,Proesmans Wdoi
10.1007/BF01959224subject
Has Abstractpub_date
1994-02-01 00:00:00pages
129-32issue
2eissn
0340-6199issn
1432-1076journal_volume
153pub_type
杂志文章abstract：UNLABELLED:We report on a 5-year-old girl with an unusually severe course of tick-borne encephalitis following passive immunization with specific hyperimmune globulin after a tick bite in an endemic area. Serial investigations of the CSF revealed intrathecal production of specific antibodies paralleled by increasing nu...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02002905
更新日期：1996-09-01 00:00:00
abstract：:Children affected with acute myocarditis may progress rapidly into profound ventricular dysfunction and ventricular arrhythmias. The objective of this study is to assess the impact of ventricular arrhythmias on in-hospital mortality and the use of mechanical circulatory support in patients with myocarditis. Pediatric ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03687-4
更新日期：2020-11-01 00:00:00
abstract：:Urinary tract infection (UTI) is a common bacterial infection among infants and children. Predicting which children with upper UTI will develop long-term sequelae remains difficult. We aimed at evaluating the predictive value of urine concentrations of interleukin-6 (UIL-6) and interleukin-8 (UIL-8) in subsequent rena...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-012-1914-2
更新日期：2013-06-01 00:00:00
abstract：:W170, i.e., the work rate at a heart frequency of 170 beats per minute, and maximal oxygen uptake were determined in one performance in 20 boys and 23 girls from 6 to 16 years of age on a bicycle ergometer. The results were related to normal values according to age and height. In different age and sex groups correlati...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00463741
更新日期：1976-06-08 00:00:00
abstract：UNLABELLED:Group A streptococcal (GAS) infection is the most common cause of bacterial pharyngitis and has an important role in the pathogenesis of post-infective phenomena including rheumatic fever and glomerulonephritis. Mortality from GAS is uncommon, particularly in the paediatric population. Toxic shock syndrome r...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-002-1032-7
更新日期：2002-09-01 00:00:00
abstract：UNLABELLED:Dent disease is an X-linked tubulopathy mainly caused by inactivating mutations of CLCN5. Features of Bartter syndrome such as hypokalemic metabolic alkalosis are rarely observed in patients with Dent disease. We report a Japanese male patient with Dent disease who also manifested features of Bartter syndrom...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-011-1578-3
更新日期：2012-02-01 00:00:00
abstract：:We aimed to assess the prevalence and outcomes of esophageal perforation in very low birth weight infants. This retrospective cohort study utilized the US National Inpatient Sample dataset for the years 2000 to 2017. A total of 1,755,418 very low birth weight infants were included; of them, 861 (0.05%) were diagnosed ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03894-z
更新日期：2021-02-01 00:00:00
abstract：UNLABELLED:This study compared the foot morphology of Spanish schoolchildren based on their body mass index and age and analyzed whether body mass index affects the child's foot development at primary school. Cross-sectional study of 1,032 schoolchildren (497 boys and 535 girls), 6-12 years old. Height and weight were ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-013-1944-4
更新日期：2013-05-01 00:00:00
abstract：UNLABELLED:To determine bilirubin-induced neurotoxicity, serial visual evoked potentials (VEPs) of 72 infants with neonatal hyperbilirubinaemia and 22 controls were evaluated and compared in four sessions for 8 weeks after birth. The levels of maximal serum bilirubin were found positively related to the wave latencies ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02079073
更新日期：1995-08-01 00:00:00
abstract：UNLABELLED:Children's right to access safe and effective medicines is recognised globally. Ethanol, used in paediatric liquid formulations as a solvent and preservative, is associated with safety concerns with respect to both acute ingestion and chronic exposure. In addition, families may have cultural or religious val...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-013-1972-0
更新日期：2013-07-01 00:00:00
abstract：:Piritramide is indicated for treatment of postoperative pain and analgosedation in the intensive care unit (ICU) setting. In an open prospective study the pharmacokinetics of piritramide were investigated in four groups: newborns (NB, age: 1-28 days) (n=8), infants 1 (IF1, age: 2-4 months) (n=7), infants 2 (IF2, age: ...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章
doi：10.1007/s00431-005-0021-z
更新日期：2006-04-01 00:00:00
abstract：UNLABELLED:The need to reappraise sedation policy is dictated by newer noninvasive imaging modalities. In this study we evaluate the safety and efficacy of rectally-administered thiopental in children undergoing MRI. Eighty-three consecutive patients with congenital heart disease (mean age 2.9 years, SD 2.5) undergoing...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：:A pure growth of Branhamella catarrhalis was obtained from a purulent bronchial exudate in a 28-month-old Rwandese girl, hospitalized for acute inspiratory dyspnoea with fever. The outcome was favourable under treatment with ampicillin, although the isolate was shown to produce a beta-lactamase in vitro. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442307
更新日期：1985-03-01 00:00:00
abstract：:A bulging fontanelle due to benign increased intracranial pressure is not generally recognized as a manifestation of nutritional rickets but should be considered in the appropriate clinical setting. Two children who we saw presented with bulging anterior fontanelles were found to have pseudotumor cerebri in associatio...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442144
更新日期：1985-01-01 00:00:00
abstract：:CD3+4-8- double negative cells in peripheral blood lymphocytes were examined in 21 severely handicapped children divided into two groups according to serum IgG level. All children were bedridden and were taking multiple anticonvulsants and there were no apparent clinical differences between these two groups. Serum lev...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01954738
更新日期：1994-12-01 00:00:00
abstract：:Recent studies revealed that fluid overload is associated with higher mortality in critically ill children and adults. This study aimed to evaluate the association between fluid overload in the first 3 days of life and mortality in extremely low birth weight infants. This single-center retrospective cohort study inclu...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03654-z
更新日期：2020-11-01 00:00:00
abstract：:We report the 9-year follow-up of a patient suffering from N-acetylglutamate synthetase deficiency, an urea cycle disorder leading to severe neonatal hyperammonaemia. Hitherto two patients from two families with this inborn error of metabolism had been observed. Our management consisted mainly of a protein-restricted ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01955939
更新日期：1991-03-01 00:00:00
abstract：:Serum bile acids and their conjugates were analysed in 20 breast-fed infants with prolonged jaundice. The mean total bile acid levels in serum were increased in the breast-fed infants with jaundice, as compared with those in either breast- or bottle-fed infants without jaundice. However, there were no significant diff...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00491922
更新日期：1985-05-01 00:00:00
abstract：:The daily excretion of C-peptide in the urine was measured in 105 healthy infants and children from birth to 14 years of age. For technical reasons no studies were performed from 1-3 years of age. The excretion of C-peptide showed a close positive correlation with age and weight. The relationship with weight was alrea...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442133
更新日期：1985-01-01 00:00:00
abstract：:Achondroplasia, the most common form of chondrodysplasia, has been associated with mutations in the gene of the fibroblast growth factor receptor-3 (FGFR-3) on chromosome 4p. All 39 achondroplasia alleles studied so far carried point mutations which caused the same amino acid exchange, a substitution of glycine by arg...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01954274
更新日期：1995-03-01 00:00:00
abstract：:Exchange transfusion using a peripheral artery and vein was carried out 18 times in 17 newborn infants. The arteries use to withdraw blood were the radial [13], the ulnar [3] an the posterior tibial [2]. Infusion of blood was carried out simultaneously through a peripheral vein. There was no mortality or morbidity dir...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00443258
更新日期：1981-11-01 00:00:00
abstract：:Failure to thrive, feeding difficulties, variable forms of infantile epilepsy or psychomotor developmental delay and hypotonia were the most frequent clinical disease presentations in eight children with combined oxidative phosphorylation enzyme complex deficiencies carrying mutations in the polymerase gamma (POLG1) g...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-006-0234-9
更新日期：2007-03-01 00:00:00
abstract：:A combination of humoral immunodeficiency and isolated growth hormone deficiency was observed in a girl with Mulibrey nanism. The humoral immunodeficiency consisted of subnormal concentration of serum IgG, in particular IgG2 and IgG4, and low concentration of serum IgM. Serum IgA and IgD were elevated, IgE was absent....
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01955061
更新日期：1993-06-01 00:00:00
abstract：:We report two children with hemolytic anemia during the course of hepatitis A infection. On admission, the patients had high blood urea nitrogen, creatinine, and uric acid levels, as well as anemia, leucocytosis, and direct and indirect hyperbilirubinemia. Both patients had a glucose-6-phosphate dehydrogenase deficien...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-008-0694-1
更新日期：2008-12-01 00:00:00
abstract：:Premature newborns are particularly vulnerable to iatrogenic hypothyroidism due to iodine exposure, usually through skin absorption of iodine-containing disinfectants or intravenous administration of iodinated contrast agents. We report here a case of severe iatrogenic hypothyroidism with goiter and cholestasis, disco...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-008-0782-2
更新日期：2009-04-01 00:00:00
abstract：:We describe the natural history of the RTSII phenotype in a 7-year-old boy who developed intrauterine and postnatal growth retardation, failure to thrive and persisting diarrhoea. The growth hormone stimulation test identified an isolated growth hormone deficiency. Since infancy, the patient manifested skin lesions ch...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-007-0447-6
更新日期：2008-02-01 00:00:00
abstract：:Abnormalities of chromosome 14 are encountered infrequently in clinical cytogenetics and only few studies of paracentric inversion have been published. This paper reports the first case of hypospadias associated with paracentric inversion of chromosome 14. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441748
更新日期：1986-02-01 00:00:00
abstract：:Effective management of pain remains an important indicator of the quality of care provided to neonates. Since the review of McIntosh in this journal over a decade ago, an extensive number of papers on assessment, prevention, and treatment of pain have been reported. In addition, preclinical insights into neurodevelop...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-009-0932-1
更新日期：2009-07-01 00:00:00
abstract：UNLABELLED:Cleidocranial dysplasia (CCD; MIM 119600) is an autosomal dominant skeletal dysplasia characterised by hypoplastic clavicles, patent fontanelles, short stature, tooth anomalies and other variable skeletal changes. Different mutations of the RUNX2/CBFA1 gene (MIM 600211) have been detected in patients with CC...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-002-0977-x
更新日期：2002-11-01 00:00:00
abstract：:A 16-year-old girl developed rapidly progressive glomerulonephritis and renal failure. The disease was associated with high titres of antiglomerular basement membrane antibodies in serum, linear deposits of immunoglobulin G and diffuse epithelial crescents on renal biopsy. Past history revealed heavy smoking and delib...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00716479
更新日期：1987-05-01 00:00:00
