The effect of age and body size on the urinary excretion of C-peptide from birth to 14 years of age.

Abstract:

:The daily excretion of C-peptide in the urine was measured in 105 healthy infants and children from birth to 14 years of age. For technical reasons no studies were performed from 1-3 years of age. The excretion of C-peptide showed a close positive correlation with age and weight. The relationship with weight was already apparent in the 1st days of life. The C-peptide/weight and the C-peptide/creatinine ratios were constant throughout most of childhood with the exception of the age range of 1 month-1 year when the C-peptide/creatinine was significantly higher. In obese children the C-peptide/weight and C-peptide/creatinine ratios were similar to those found in children with normal weight. In growth hormone deficiency these ratios were low and increased during the 1st week of growth hormone therapy. It is concluded that urinary C-peptide is a reliable indicator of integrated insulin production and gives new information about insulin secretion in various conditions.

journal_name

Eur J Pediatr

authors

Gács G,Jakabfi P,Zubovich L

doi

10.1007/BF00442133

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

183-6

issue

3

eissn

0340-6199

issn

1432-1076

journal_volume

143

pub_type

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