Abstract：
:Respiratory and arousal responses to mild hypoxia (15% oxygen in nitrogen) were recorded in 18 healthy infants and 33 infants who had sustained severe sleep related apnoeic events (ALTE). Respiratory movements and transcutaneous gas pressures (tcPO2 and tcPCO2) were continuously monitored during the 10 min test. The changes in tcPCO2 in relation to the decrease in tcPO2 were used as an index of the ventilatory and metabolic responses to hypoxia. We found that the response of apnoeic infants was within the range of the controls although the distribution of the individual response slopes was shifted towards the lower end of the range. Arousal was observed in 33% of apnoeic infants and 32% of the controls. Regular periodic breathing occurred in 42% of apnoeic infants compared to 28% of controls. In contrast to the controls, periodic breathing in apnoeic infants was not associated with a drop in tcPCO2 to below baseline levels. Apnoeic infants also alternated between regular and periodic breathing during the test. These findings are suggestive of a weak feed back control of breathing but do not support former views of a deficient hypoxic response in infants with ALTE.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Milerad J,Hertzberg T,Wennergren G,Lagercrantz Hdoi
10.1007/BF00441560subject
Has Abstractpub_date
1989-04-01 00:00:00pages
565-70issue
6eissn
0340-6199issn
1432-1076journal_volume
148pub_type
杂志文章abstract：:We report a prospective, non-blind, randomised, multicentre, parallel group, multinational investigation to compare ceftazidime to aminoglycoside based regimens as empirical treatment in 1316 cases of suspected sepsis in the newborn. In each of the 15 study centres either ceftazidime alone (CAZ) or ceftazidime + ampic...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF01954122
更新日期：1992-12-01 00:00:00
abstract：UNLABELLED:Human parechoviruses (HPeV) have been recently recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence in infants <1 month in Spain and, secondly, to analyse the clinical and epidemiological characteristics of the infected patien...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/s00431-015-2566-9
更新日期：2015-11-01 00:00:00
abstract：:We report on a 3-year-old boy presenting with left-sided eyelid myocloni due to an intracranial abscess harboring Haemophilus paraphrophilus. This is the first description of an intracranial infection with this pathogen in a child. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-007-0560-6
更新日期：2008-06-01 00:00:00
abstract：LARYNGOSCOPE BURNS IN NEONATAL INTUBATION:Following burns during neonatal intubation, we mounted an in vitro study of laryngoscopes to determine the temperatures reached during clinical use. The temperature of 10 different bulb laryngoscopes heads and two fibre optic heads were measured with a thermocouple, once opened...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-019-03381-0
更新日期：2019-07-01 00:00:00
abstract：:An apparently hitherto undescribed, severe skeletal syndrome is reported in 3 siblings (2 boys, 1 girl) in a family of Turkish-Arabian descent. Major manifestations include: hypoplasia of the pelvis, congenital dislocation of the hip, severe bowing of femora, aplasia or hypoplasia of fibulae, absence or coalescence of...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441580
更新日期：1980-03-01 00:00:00
abstract：UNLABELLED:The inherited ion channel disorders (channelopathies) are a group of disorders caused by mutations in genes encoding ion channels. Ion channel disorders can affect any tissue, but the majority affect skeletal muscle or the central nervous system. These disorders include skeletal muscle sodium channelopathies...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/pl00014403
更新日期：2000-12-01 00:00:00
abstract：UNLABELLED:Papillomas of the genital region are rare benign tumours causing sanguineous vaginal discharge in prepubertal girls. We report on a papilloma of the cervix in a 2-year-old girl. We characterize the tumour immunohistochemically and give a brief review about the current literature. CONCLUSION:Genital tract pa...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s004310050609
更新日期：1997-04-01 00:00:00
abstract：:We evaluated, both in toilet-trained and not-toilet-trained children, the impact of cleaning the genital area with plain water on the false positive rate at urine dipstick, and evaluated which factors could be associated to falsely positive findings. We prospectively enrolled 612 patients consecutively attending our n...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-018-3215-x
更新日期：2018-10-01 00:00:00
abstract：:The correlation between a releasable pituitary growth hormone (GH) pool and degree of growth failure was examined in 30 children with GH deficiency (group I) and 19 children with normal short stature (group II). Based on the responsiveness of GH to GH-releasing hormone (GHRH), group I, with low GH responses (below 7 n...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442468
更新日期：1988-08-01 00:00:00
abstract：:Allergic diseases are on the increase and can affect the child's well-being. The aim of this survey was to assess regional schools' preparedness in dealing with anaphylaxis following the publication of national and international guidelines for schools in 2014. The survey was developed in 2015 and distributed to school...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03645-0
更新日期：2020-10-01 00:00:00
abstract：:The aim of this study was to assess the influence of active and passive maternal smoking on placenta total oxidant/antioxidant status in term infants. The levels of cord blood total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) were measured in samples of fetal placental tiss...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-010-1338-9
更新日期：2011-05-01 00:00:00
abstract：:Serial ultrasound examinations were performed through the anterior fontanelle to detect and follow subependymal pseudocysts (SP) in 19 neonates without severe malformations. A high-resolution real-time sector scanner was employed. In 8 cases the SP involved both lateral ventricles, in 11 cases they were unilateral and...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00595915
更新日期：1989-02-01 00:00:00
abstract：:We evaluated polymorphonuclear leucocyte (PMN) chemotaxis and cortisol levels in cord blood from 15 healthy term infants delivered by caesarean section and from 15 healthy vaginally delivered term infants. Mean neutrophil chemotaxis was significantly higher in infants delivered by caesarean section (78.3 +/- 23.4 micr...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01958427
更新日期：1991-05-01 00:00:00
abstract：UNLABELLED:Hypotension is a commonly diagnosed and treated complication of extremely low gestational age newborns (ELGAN), but enormous variation in diagnosis, management and clinical practice has been documented. We sought to evaluate practice regarding the management of hypotension in ELGANs and developed a web-based...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/s00431-013-2251-9
更新日期：2014-06-01 00:00:00
abstract：:Since immunological disorders have been demonstrated in patients with Diamond-Blackfan anaemia (DBA), intravenous immunoglobulins (IVIG) were administered to a 14-year-old girl with DBA and congenital malformations, previously treated with corticosteroids and blood transfusions. No therapeutic effect was observed. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01957279
更新日期：1990-08-01 00:00:00
abstract：UNLABELLED:The pattern and distribution of subcutaneous fat in term and preterm newborns has been assessed by skinfold thicknesses (ST), describing gender and gestational age variations. Weight, length and ST (triceps, biceps, subscapular and suprailiac) were measured in 4634 neonates (2445 males and 2189 females) aged...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-004-1468-z
更新日期：2004-08-01 00:00:00
abstract：:Paediatric patients are more vulnerable to drug administration errors due to a lack of appropriate drug dosages and strengths for use in this group of patients. Therefore, the aim of the present study was to determine the extent and types of drug administration errors in two paediatric wards and to identify measures t...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-009-1084-z
更新日期：2010-05-01 00:00:00
abstract：UNLABELLED:To determine bilirubin-induced neurotoxicity, serial visual evoked potentials (VEPs) of 72 infants with neonatal hyperbilirubinaemia and 22 controls were evaluated and compared in four sessions for 8 weeks after birth. The levels of maximal serum bilirubin were found positively related to the wave latencies ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02079073
更新日期：1995-08-01 00:00:00
abstract：:Adolescence obesity and depression are increasingly prevalent and are associated with various health complications. The aim of this study was to examine the association between weight status (normal weight, overweight, and obese) and depressive symptoms in adolescents and to explore the probable mediators, including o...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-012-1753-1
更新日期：2012-08-01 00:00:00
abstract：UNLABELLED:Patients with glycogen storage disease type 1b (GSD1b) not only show hepatomegaly, hypoglycaemia and lactic acidosis, but also neutropenia and neutrophil dysfunction. Here, we report improvement of neutropenia and neutrophil function in a 22-year-old male GSD1b patient who had undergone living-related partia...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-004-1405-1
更新日期：2004-04-01 00:00:00
abstract：UNLABELLED:To assess the role of dexamethasone treatment as a cause of systemic hypertension and associated complications, blood pressure was registered prospectively before, during and after a 4-week dexamethasone course in 22 neonates with chronic lung disease. In all patients systolic blood pressure rose significant...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章
doi：10.1007/BF01957907
更新日期：1996-07-01 00:00:00
abstract：UNLABELLED:Transient hypothyroxinaemia with normal thyroid stimulating hormone (TSH) levels is a well-known condition in preterm neonates and is generally assumed to be a harmless epiphenomenon of prematurity. This assumption is, however, based on studies that included very few neonates with a gestational age (GA) belo...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01953940
更新日期：1996-03-01 00:00:00
abstract：:Iron deficiency is frequently associated with anemia. Iron is a transition-metal ion, and it can induce free radical formation, which leads to formation of various lesions in DNA, proteins, and lipids. The aim of this study was to investigate baseline oxidative DNA damage and to clarify the role of the administration ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-010-1147-1
更新日期：2010-08-01 00:00:00
abstract：:Recently a novel and non-invasive technique of lower leg length measurement (knemometry) was introduced. The method estimates the distance between heel and knee in the sitting child with an accuracy of 0.09 mm(SD). Two female patients with anorexia nervosa, aged 14:4 and 13:7 years, weighing minus 27 and minus 38% of ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02467353
更新日期：1987-11-01 00:00:00
abstract：:Proper nutrition throughout childhood and adolescence is crucial for normal bone development. We investigated whether adherence to Christian Orthodox Church fasting is characterized by periodic avoidance of animal foods (including dairy products), since childhood affects stature or bone health in young adults. This cr...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-019-03542-1
更新日期：2020-04-01 00:00:00
abstract：:A 9-year-old girl presented with a red scaly rash confined to sun-exposed areas which started at 2 years of age and had the appearance of pellagra. Investigation of urinary tryptophan metabolites following an oral tryptophan load, showed increased excretion of kynurenine and kynurenic acid but reduced excretion of 3-h...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01958432
更新日期：1991-05-01 00:00:00
abstract：INTRODUCTION:This randomised, observer-blind clinical trial conducted in Turkey evaluated the immunogenicity, safety and interchangeability of three paediatric inactivated hepatitis A vaccines in 424 seronegative children between 1 and 15 years of age. METHODS:Potential subjects were screened for anti-hepatitis A viru...
journal_title：European journal of pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00431-007-0432-0
更新日期：2007-06-01 00:00:00
abstract：:The varying clinical manifestations of Lyme borreliosis, transmitted by Ixodes ricinus and caused by Borrelia burgdorferi, frequently pose diagnostic problems. Diagnostic strategies vary between early and late disease manifestations and usually include serological methods. Erythema migrans is pathognomonic and does no...
journal_title：European journal of pediatrics
pub_type： 杂志文章,实务指引
doi：10.1007/s00431-012-1779-4
更新日期：2012-11-01 00:00:00
abstract：:Six patients are described with a combination of early onset of neurological symptoms, gross cerebral changes and elevated concentrations of pyruvate and lactate in cerebrospinal fluid. Although at least five of the six patients appear to have a generalised defect in pyruvate metabolism, reflected in deficient pyruvat...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442603
更新日期：1988-01-01 00:00:00
abstract：:The incidence of intussusception in infants varies around the world. The epidemiology of intussusception in France has never been prospectively studied. We performed a prospective observational study with systematic inclusion of all infants aged <1 year with suspected intussusception admitted to the emergency departme...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/s00431-016-2838-z
更新日期：2017-03-01 00:00:00
