Abstract:
UNLABELLED:Human parechoviruses (HPeV) have been recently recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence in infants <1 month in Spain and, secondly, to analyse the clinical and epidemiological characteristics of the infected patients compared with those infected by enterovirus (EV). Infants <1 month with neurological or systemic symptoms were included in a multicentre prospective study. EV and HPeV detection by RT-PCR and genotyping were performed in cerebrospinal fluids (CSF), sera or throat swabs. Out of the total of 84 infants studied during 2013, 32 were EV positive (38 %) and 9 HPeV positive (11 %). HPeV-3 was identified in eight cases and HPeV-5 in one. Mean age of HPeV-positive patients was 18 days. Diagnoses were fever without source (FWS) (67 %), clinical sepsis (22 %) and encephalitis (11 %). Leukocytes in blood and CSF were normal. Pleocytosis (p = 0.03) and meningitis (p = 0.001) were significantly more frequent in patients with EV infections than with HPeV. CONCLUSIONS:Although HPeV-3 infections were detected less frequently than EV, they still account for approximately 10 % of the cases analysed in infants younger than 1 month. HPeV-3 was mainly associated with FWS and without leukocytosis and pleocytosis in CSF. In these cases, HPeV screening is desirable to identify the aetiologic agent and prevent unnecessary treatment and prolonged hospitalization.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Cabrerizo M,Trallero G,Pena MJ,Cilla A,Megias G,Muñoz-Almagro C,Del Amo E,Roda D,Mensalvas AI,Moreno-Docón A,García-Costa J,Rabella N,Omeñaca M,Romero MP,Sanbonmatsu-Gámez S,Pérez-Ruiz M,Santos-Muñoz MJ,Calvo C,studydoi
10.1007/s00431-015-2566-9subject
Has Abstractpub_date
2015-11-01 00:00:00pages
1511-6issue
11eissn
0340-6199issn
1432-1076pii
10.1007/s00431-015-2566-9journal_volume
174pub_type
杂志文章,多中心研究abstract:UNLABELLED:An 8-year-old boy with frequently recurring pancreatitis-like abdominal pain, Fredrickson type V dyslipidaemia, and significantly decreased post-heparin plasma lipoprotein lipase (LPL) activity is described. In order to exclude familial LPL deficiency, the complete LPL coding gene sequence was analysed revea...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01957148
更新日期:1996-08-01 00:00:00
abstract:UNLABELLED:Neutrophils are an essential component of the human host defence system against infection. Recombinant human granulocyte colony-stimulating factor induces neutrophilia and enhances effector functions of mature neutrophils. Since the biological effects of granulocyte colony-stimulating factor (G-CSF) are medi...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s004310051129
更新日期:1999-06-01 00:00:00
abstract:UNLABELLED:Adolescents are becoming more independently responsible for their medication regimen; therefore, adolescence is a crucial period to address medication beliefs, as many of the beliefs may persist into adulthood and can impair adherence and willingness to continue a prescribed therapy. Within this study, we ai...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-013-2211-4
更新日期:2014-04-01 00:00:00
abstract::In order to determine the hepatotoxicity of rifampicin in children treated for tuberculosis, a survey was performed of 18 children receiving this medicine in combination with isoniazid. Fifteen of the 18 children (83%) showed a rise in ASAT values and 11 (61%) in ALAT values exceeding 29U/L. Seven children with maxima...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00441477
更新日期:1980-09-01 00:00:00
abstract:UNLABELLED:In patients with propionic acidaemia (PA), the increased intracellular concentration of propionyl-CoA leads to a relative abundance of odd-numbered long-chain fatty acids (OLCFAs) in body lipids. We investigated the relative amount of OLCFA in erythrocyte membrane lipids over a period of 1-8 years in five pa...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s004310050010
更新日期:2000-01-01 00:00:00
abstract::The aim of this study was to determine whether macrosomia related to maternal diabetes alters lipoprotein metabolism and whether these abnormalities still persist or regress after 1 month of life. Serum lipoprotein compositions and concentrations as well as serum lipid fatty acid compositions were investigated in macr...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s004310051194
更新日期:1999-09-01 00:00:00
abstract:UNLABELLED:Fifty-two cases of childhood brucellosis which occurred in north-western Greece during the 15-year period 1979-1993, are reviewed. It is believed that they represent very closely the total incidence of the disease in the region which has a population of 100,000 children aged 0-14 years old. Brucellosis-affec...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02115616
更新日期:1996-01-01 00:00:00
abstract::We report on a newborn infant with complex congenital heart disease (CHD) featuring double outlet right ventricle and hypoplastic left ventricle who had postductal oxygen saturation well above 95% and thus eluded pulse oximetry screening for CHD. ...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-006-0283-0
更新日期:2007-06-01 00:00:00
abstract::Local control of the primary tumour is a fundamental requirement for clinical cure. Towards this aim, the primary tumour must be diagnosed early and identified histologically. The size, extension, and spread within the patient must be defined precisely. In planning effective local therapy, additional questions must be...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00451896
更新日期:1985-07-01 00:00:00
abstract::Haemostasis was studied in 8 tall girls during treatment with high doses of synthetic oestrogens for a period of 1 to 28 months. The girls received 0.5 mg ethinyloestradiol daily from day 1 to day 25 and 15 mg norethisteron daily from day 21 to day 25. All were without clinical signs of thromboembolism. Factors of the...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00441480
更新日期:1980-09-01 00:00:00
abstract::By November 1994, 39 pregnancies had been completed in phenylketonuric mothers. Dietary control was post-conception in 6 and 2 of these offspring died of congenital heart disease and 1 other needed surgery for coarctation. There were no heart defects in the 34 offspring of the 33 pregnancies following preconception di...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/pl00014242
更新日期:1996-07-01 00:00:00
abstract:LARYNGOSCOPE BURNS IN NEONATAL INTUBATION:Following burns during neonatal intubation, we mounted an in vitro study of laryngoscopes to determine the temperatures reached during clinical use. The temperature of 10 different bulb laryngoscopes heads and two fibre optic heads were measured with a thermocouple, once opened...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-019-03381-0
更新日期:2019-07-01 00:00:00
abstract::In 41 preterm neonates with a gestational age (GA) varying from 27 to 36 weeks, glomerular filtration rate (GFR) was measured by means of the continuous inulin infusion technique. The reliability of the technique was confirmed. During postnatal development GFR was found to increase in two ways: firstly, an increase wi...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00441807
更新日期:1988-10-01 00:00:00
abstract:UNLABELLED:Our aim was to study the frequency and clinical correlates of two radiographic patterns of bronchopulmonary dysplasia (BPD), the cystic BPD (cBPD) and the leaky lung syndrome (LLS). Radiographic findings of BPD from sixth day of life until term in a cohort of 82 very low birth weight (VLBW) infants were eval...
journal_title:European journal of pediatrics
pub_type: 临床试验,杂志文章
doi:10.1007/s00431-011-1486-6
更新日期:2012-01-01 00:00:00
abstract:UNLABELLED:Papillomas of the genital region are rare benign tumours causing sanguineous vaginal discharge in prepubertal girls. We report on a papilloma of the cervix in a 2-year-old girl. We characterize the tumour immunohistochemically and give a brief review about the current literature. CONCLUSION:Genital tract pa...
journal_title:European journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s004310050609
更新日期:1997-04-01 00:00:00
abstract::Serum immunoreactive erythropoietin (siEPO) was determined in cord serum from neonates (n = 97, gestational age 36-43 weeks), in healthy children from birth to adolescence (n = 260) and in children with haematological (n = 30), renal (n = 10) and congenital heart diseases (n = 70). In healthy children siEPO levels dec...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01959395
更新日期:1990-04-01 00:00:00
abstract::Prolonged emergency department (ED) length of stay (LOS) is used as a proxy for ED overcrowding and is associated with adverse outcomes of patients requiring therapy and reduced patient satisfaction. Our aim was to identify and quantify variables which affect ED-LOS. Patients admitted to the pediatric ED of a large re...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-017-2879-y
更新日期:2017-05-01 00:00:00
abstract:UNLABELLED:This study aimed to determine the population pharmacokinetics of doxapram in low-birth-weight (LBW) infants. A total of 92 serum concentration measurements that were obtained from 34 Japanese neonates were analyzed using nonlinear mixed-effect modeling (NONMEM). Estimates generated by NONMEM indicated that c...
journal_title:European journal of pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00431-014-2416-1
更新日期:2015-04-01 00:00:00
abstract::Clinically visible corneal opacities were observed in a patient with an extremely severe form of mucopolysaccharidosis II. In a second patient with an unusually mild form of mucopolysaccharidosis II, discrete corneal opacities were detected by slit-lamp examination. Thus clear corneae can no longer be regarded as a ha...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00441369
更新日期:1978-08-17 00:00:00
abstract::A case of lithium intoxication in the newborn is presented. Besides displaying extreme hypotonia and a goitre, the infant developed symptoms of congenital heart disease immediately after birth. Cardiac catheterization and angiocardiography revealed an elevated pulmonary vascular resistance and indicated that the cardi...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00442508
更新日期:1982-07-01 00:00:00
abstract::The new coronavirus disease outbreak in 2019 (COVID-19) represents a dramatic challenge for healthcare systems worldwide. As to viral tropism, lungs are not the only COVID-19 target but also the heart may be involved in a not negligible percentage of the infected patients. Myocarditis-related cardiac dysfunction and p...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-020-03699-0
更新日期:2020-07-01 00:00:00
abstract::Clinical pharmacists provide beneficial services to adult patients, though their benefits for paediatric hospital patients are less defined. Five databases were searched using the MeSH terms 'clinical pharmacist', 'paediatric/paediatric', 'hospital', and 'intervention' for studies with paediatric patients conducted in...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-018-3187-x
更新日期:2018-08-01 00:00:00
abstract:UNLABELLED:Methanol poisoning is not frequently observed in children; however, without treatment, serious intoxication can be complicated by visual impairment, coma, metabolic acidosis, respiratory and circulatory insufficiency and death. Treatment in a paediatric intensive care is therefore compulsory. Methanol is met...
journal_title:European journal of pediatrics
pub_type: 杂志文章,评审
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更新日期:2005-03-01 00:00:00
abstract::Anthropometric indices (AI) have been known to be associated with age at menarche (AAM). The aim of this longitudinal study was to evaluate the changes in AI and its association with AAM in a community-based population in Iran. From among 10,192 women, we included 6818, aged ≥ 10 years, who were post-menarche at the t...
journal_title:European journal of pediatrics
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
abstract::The pre- and postnatal clinical, cytogenetic and embryological findings in a family suffering from trisomy 9p and spinal muscular atrophy are presented. The clinical picture of the "trisomy 9p" -syndrome is delineated. Concurrence of autosomal aberration and spinal muscular atrophy, probably of the Werdnig-Hoffmann ty...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00443119
更新日期:1977-08-23 00:00:00
abstract::Following a description of the genetic aspects of the human histocompatibility antigens system HLA and its principle typing methods, this paper reviews the relationship between HLA antigens, transplantation immunology and certain diseases. In particular, the role of the lymphocyte-defined antigens of the HLA-D system ...
journal_title:European journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF00441576
更新日期:1980-03-01 00:00:00
abstract:UNLABELLED:The treatment of blunt splenic injuries (BSI) has undergone a significant shift away from an operative approach to a conservative treatment regimen in the last decades. Data concerning long-term follow-up of children sustaining BSI are largely confined to telephone surveys. Children treated with BSI over a 3...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-013-2022-7
更新日期:2013-09-01 00:00:00
abstract::A 4-month-old infant was admitted to the Pediatric Intensive Care Unit with Pneumococcal meningitis. A few hours after admission he developed intractable convulsions that could not be stopped with phenytoin, phenobarbitone and a continuous drip of diazepam. Thiopentone sodium anaesthesia was induced for 24 h terminati...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00441663
更新日期:1983-04-01 00:00:00
abstract:UNLABELLED:Coagulase-negative staphylococci are the most common cause of late-onset sepsis in premature neonates. The optimal approach in persistent coagulase-negative staphylococcal bacteremia, despite adequate treatment with glycopeptides, is not well established. A retrospective study was conducted on preterm neonat...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-012-1927-x
更新日期:2013-05-01 00:00:00
abstract:UNLABELLED:A collaborative study, supported by the Biomed2 Programme of the European Community, was initiated to optimise the aetiological diagnosis in genetic or gonadal males with intersex disorders, a total of 67 patients with external sexual ambiguity, testicular tissue and/or a XY karyotype. In patients with gonad...
journal_title:European journal of pediatrics
pub_type: 杂志文章,多中心研究,评审
doi:10.1007/s00431-001-0854-z
更新日期:2002-01-01 00:00:00