Children's heart and COVID-19: Up-to-date evidence in the form of a systematic review.

Abstract:

:The new coronavirus disease outbreak in 2019 (COVID-19) represents a dramatic challenge for healthcare systems worldwide. As to viral tropism, lungs are not the only COVID-19 target but also the heart may be involved in a not negligible percentage of the infected patients. Myocarditis-related cardiac dysfunction and potentially life-threatening arrhythmias are the main aftermaths. A few studies showed that myocardial injury in adult patients is often linked with a fatal outcome. Conversely, scientific evidence in children is sparse, although several reports were published with the description of a cardiac involvement in COVID-19 paediatric patients. In these young subjects, a background of surgically treated congenital heart disease seems to be a predisposing factor.Conclusion: This systematic review is aimed at summarizing all COVID-19 cases with a cardiac involvement published in paediatric age and trying to explain the underlying mechanisms responsible for COVID-19-related myocardial damage.What is Known:• Coronaviruses proved to be able to jump from animals to humans.• The outbreak of COVID-19 started from China (Dec 2019) and became pandemic.What is New:• Even in childhood, COVID-19 is not without the risk of cardiac involvement.• Myocarditis, heart failure, and arrhythmias are among the possible manifestations.

journal_name

Eur J Pediatr

authors

Sanna G,Serrau G,Bassareo PP,Neroni P,Fanos V,Marcialis MA

doi

10.1007/s00431-020-03699-0

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

1079-1087

issue

7

eissn

0340-6199

issn

1432-1076

pii

10.1007/s00431-020-03699-0

journal_volume

179

pub_type

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