Abstract：
UNLABELLED:This study aimed to determine the population pharmacokinetics of doxapram in low-birth-weight (LBW) infants. A total of 92 serum concentration measurements that were obtained from 34 Japanese neonates were analyzed using nonlinear mixed-effect modeling (NONMEM). Estimates generated by NONMEM indicated that clearance of doxapram (CL; L/kg/h) was affected by postmenstrual age (PMA; weeks), body weight (BW; g), and aspartate aminotransferase (AST; IU/L). In addition, the volume of distribution (Vd; L/kg) was affected by gestational age (GA; weeks). The final pharmacokinetic model was as follows: CL = BW / PMA × 0.0453 × serum AST(-0.373); Vd = 2.54 (if GA >28 weeks) and Vd = 2.54 × 2.11 (if GA ≤28 weeks). The interindividual variabilities in CL and Vd were 39.9 and 83.0 %, respectively, and the residual variability was 20.9 %. To clarify the reasons for large interindividual variations, the enzymes involved in the metabolic pathway of doxapram were also determined. We found that doxapram was metabolized by CYP3A4/5. CONCLUSION:We report the population pharmacokinetics of doxapram in neonates and the involvement of CYP3A4/5 in its metabolism. The final model of population pharmacokinetics may be useful for formulating a safe and effective dosage regimen and for predicting serum doxapram concentrations in neonates.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Ogawa Y,Irikura M,Kobaru Y,Tomiyasu M,Kochiyama Y,Uriu M,Ishitsuka Y,Kondo Y,Yukawa E,Kamada N,Ohno H,Yamazaki T,Irie Tdoi
10.1007/s00431-014-2416-1subject
Has Abstractpub_date
2015-04-01 00:00:00pages
509-18issue
4eissn
0340-6199issn
1432-1076journal_volume
174pub_type
杂志文章,多中心研究,随机对照试验abstract：UNLABELLED:We report fives sporadic cases of hyperekplexia or startle disease characterized by a highly exaggerated startle reflex and tonic attacks. Affected neonates suffer from prolonged periods of stiffness and are at risk for sudden death from apnea. An early diagnosis is needed. Sudden loud sounds, unexpected tac...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-005-0015-x
更新日期：2006-02-01 00:00:00
abstract：UNLABELLED:In acute-phase Kawasaki disease, neutrophils cause injury to the coronary arterial endothelium through the production of elastase. Previous research has demonstrated the modulation of neutrophil function and kinetics, such as development and maturation, by granulocyte colony-stimulating factor (G-CSF). To ex...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-002-1018-5
更新日期：2002-10-01 00:00:00
abstract：:The light- and electron-microscopic structure of articular and costal cartilage in a case of achondrogenesis type I has been described. The most characteristic ultrastructural change in the chondrocytes was conspicuous dilatation of the rough endoplasmatic reticulum (RER) which contained amorphous electronopaque mater...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442406
更新日期：1980-06-01 00:00:00
abstract：:Haemostasis was studied in 8 tall girls during treatment with high doses of synthetic oestrogens for a period of 1 to 28 months. The girls received 0.5 mg ethinyloestradiol daily from day 1 to day 25 and 15 mg norethisteron daily from day 21 to day 25. All were without clinical signs of thromboembolism. Factors of the...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441480
更新日期：1980-09-01 00:00:00
abstract：:A 16-year-old girl is described with abetalipoproteinaemia who underwent liver transplantation for hepatic cirrhosis. After this procedure her serum lipoprotein profile was corrected; however, fat malabsorption and steatorrhea persisted because the primary defect, a mutant microsomal triglyceride-transfer protein, rem...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050882
更新日期：1998-07-01 00:00:00
abstract：UNLABELLED:We describe the clinical and immunological features of two families with chronic mucocutaneous candidiasis (CMC) and primary hypothyroidism. Family A includes three siblings with both candidiasis and hypothyroidism and four individuals with hypothyroidism only. Family B includes four members with candidiasis...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-004-1516-8
更新日期：2004-10-01 00:00:00
abstract：:Adolescents have specific healthcare needs distinct from adults or younger children secondary to anatomical, physiological and socio-behavioural differences. Healthcare providers have been slow to address this, leading the UK Department of Health (2011) to publish 'You're Welcome' quality criteria for services for you...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-016-2815-6
更新日期：2017-02-01 00:00:00
abstract：:Neonatal acute respiratory distress syndrome (NARDS) reflects pulmonary surfactant dysfunction, and the usage of bovine surfactant (Calsurf) supplement may therefore be beneficial. To determine whether bovine surfactant given in NARDS can improve oxygenation and survival rate, we conducted a multicenter, randomized tr...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03821-2
更新日期：2020-10-21 00:00:00
abstract：:Necrotizing enterocolitis (NEC) is usually considered to be a neonatal disease, and is rarely described beyond the newborn period. During the last 15 years, 19 infants from the Negev region, Israel, with NEC were beyond the neonatal age group (range = 34-616 days, median = 90 days). Of this group only 16% were born pr...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442592
更新日期：1984-04-01 00:00:00
abstract：:A 16-year-old girl developed rapidly progressive glomerulonephritis and renal failure. The disease was associated with high titres of antiglomerular basement membrane antibodies in serum, linear deposits of immunoglobulin G and diffuse epithelial crescents on renal biopsy. Past history revealed heavy smoking and delib...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00716479
更新日期：1987-05-01 00:00:00
abstract：:We describe the natural history of the RTSII phenotype in a 7-year-old boy who developed intrauterine and postnatal growth retardation, failure to thrive and persisting diarrhoea. The growth hormone stimulation test identified an isolated growth hormone deficiency. Since infancy, the patient manifested skin lesions ch...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-007-0447-6
更新日期：2008-02-01 00:00:00
abstract：:The Rubinstein-Taybi syndrome is a condition characterized by mental retardation, typical facial changes and broad thumbs and big toes. The cause is unknown; almost all cases are sporadic. We describe a mother and son with Rubinstein-Taybi syndrome. Literature search documented at least 413 cases with 558 sibs. An aff...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00595907
更新日期：1989-02-01 00:00:00
abstract：:Screening for coeliac disease (CD) with serum antigliadin antibodies (AGA) was performed in 1032 diabetic children and adolescents. In 8 children CD had been diagnosed before study entry. Of the remaining 1024 children, 33 had an elevated AGA titre in the first serum sample. On follow-up an elevated AGA titre was conf...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/BF00445915
更新日期：1988-11-01 00:00:00
abstract：:Most pediatric asthma guidelines offer evidence-based or best practice approaches to the management of asthma exacerbations but struggle with evidence-based approaches for severe acute asthma (SAA). We aimed to investigate current practices in children with SAA admitted to European pediatric intensive care units (PICU...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/s00431-019-03502-9
更新日期：2020-03-01 00:00:00
abstract：:We report a 19-year-old boy with an interstitial deletion of the long arm of chromosome 8 (46, XY, del(8)(pter----q23.3: :q24.13----qter)). He shows the typical clinical symptoms of tricho-rhino-phalangeal syndrome (TRPI) and severe mental retardation, however without multiple exostoses. This is the second report of a...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02034746
更新日期：1990-06-01 00:00:00
abstract：:The topography and morphology of the lacrimal ducts in newborn infants was demonstrated by means of post mortem dacryocystograms and microphotograms of histologic slides. Because of bends in the course of the lower tear duct, a percentage of probings will fail to effect satisfactory perforation of the Hasner membrane....
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442367
更新日期：1978-09-08 00:00:00
abstract：UNLABELLED:Smith-Lemli-Opitz syndrome (SLOS), a multiple congenital anomaly with severe mental retardation, is caused by decreased activity of 7-dehydrocholesterol reductase. Fifteen Hungarian patients were diagnosed with SLOS on the basis of clinical symptoms, serum cholesterol, 7-dehydrocholesterol, and molecular gen...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-012-1925-z
更新日期：2013-05-01 00:00:00
abstract：:Brain hypoxia after cardiac arrest leads to damage of the neuronal cell membrane. Citicoline is necessary for the synthesis of cell membrane. We planned to assess the neuroprotective effect of citicoline in children after cardiac arrest. This randomized controlled trial was carried out at pediatric intensive care unit...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03871-6
更新日期：2020-11-10 00:00:00
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journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310100828
更新日期：2001-12-01 00:00:00
abstract：:Tonsillectomy is one of the commonest ENT paediatric procedures. Recovery is best achieved at home, and cost-effectiveness of the day case pathway is significant in tonsillectomy. This project scrutinised the local practice regarding the effectiveness of day case pathway in paediatric tonsillectomy in a large regional...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-018-3220-0
更新日期：2018-11-01 00:00:00
abstract：:Adolescence is a period characterized by rapid physical maturation, involving bodily changes that often necessitate a reorganization of self-perception. The current study investigated the impact of menarche on the determinants of quality of life in healthy female adolescents. Data were collected from 361 healthy femal...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03594-8
更新日期：2020-06-01 00:00:00
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journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03817-y
更新日期：2020-10-03 00:00:00
abstract：:The board game Kaledo was proven to be effective in improving nutrition knowledge and in modifying dietary behavior in students attending middle and high school. The present pilot study aims to reproduce these results in younger students (7-11 years old) attending primary school. A total of 1313 children from ten scho...
journal_title：European journal of pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00431-018-3091-4
更新日期：2018-09-01 00:00:00
abstract：UNLABELLED:Fibronectin (a glycoprotein which modulates inflammation) may decrease mortality in systemic infection. Children with meningococcal disease (MCD) may have low fibronectin levels. We aimed to compare plasma fibronectin levels in children with MCD and controls, correlate fibronectin levels with interleukin-6 (...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/s004310050636
更新日期：1997-06-01 00:00:00
abstract：:CD3+4-8- double negative cells in peripheral blood lymphocytes were examined in 21 severely handicapped children divided into two groups according to serum IgG level. All children were bedridden and were taking multiple anticonvulsants and there were no apparent clinical differences between these two groups. Serum lev...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01954738
更新日期：1994-12-01 00:00:00
abstract：UNLABELLED:Breast milk samples from three groups of Brazilian women were evaluated for their inhibitory effect on enteropathogenic Escherichia coli (EPEC) adhesion to HEp-2 cells: G1, mothers delivering preterm babies of appropriate birth weight (n = 12); G2, mothers delivering term babies of low birth weight (n = 11);...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050646
更新日期：1997-06-01 00:00:00
abstract：UNLABELLED:Schimke immuno-osseous dysplasia is a multisystem disorder consisting of spondylo-epiphysial dysplasia, progressive renal insufficiency due to focal segmental glomerulosclerosis, and immunodeficiency. Cerebrovascular complications have only been described in five patients. Here we report a patient with promi...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050714
更新日期：1997-10-01 00:00:00
abstract：:Polyarteritis nodosa (PAN) is a non-frequent vasculitis of small- and medium-sized vessels. Psoriatic arthritis (PA) is described as a "unique inflammatory arthritis associated with psoriasis" with an inexact prevalence rate due to the lack of widely accepted classification criteria. We describe the case of an 11-year...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-011-1459-9
更新日期：2011-09-01 00:00:00
abstract：:In a five-year-old girl with congenital hepatic fibrosis raised erythrocyte sedimentation rate and serum gammaglobulins were noted for 3 years. Needle liver biopsy showed histological features of cholangitis and Klebsiella oxytoca was cultured from a liver biopsy specimen. Antibiotic treatment resulted in normalizatio...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01377359
更新日期：1982-11-01 00:00:00
abstract：:Respiratory and arousal responses to mild hypoxia (15% oxygen in nitrogen) were recorded in 18 healthy infants and 33 infants who had sustained severe sleep related apnoeic events (ALTE). Respiratory movements and transcutaneous gas pressures (tcPO2 and tcPCO2) were continuously monitored during the 10 min test. The c...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441560
更新日期：1989-04-01 00:00:00
