Abstract：
UNLABELLED:Fibronectin (a glycoprotein which modulates inflammation) may decrease mortality in systemic infection. Children with meningococcal disease (MCD) may have low fibronectin levels. We aimed to compare plasma fibronectin levels in children with MCD and controls, correlate fibronectin levels with interleukin-6 (IL-6), shock and death, and assess fibronectin as an aid to early diagnosis in MCD. Samples were taken on admission from 99 children with MCD and 49 controls. Plasma fibronectin was measured using a turbidimetric immunoassay. Plasma fibronectin was significantly lower in MCD compared to controls (57 micrograms/ml vs 105 micrograms/ml; P < 0.005). Children who died had significantly lower levels than survivors (29 micrograms/ml vs 62 micrograms/ml; P = 0.01). Fibronectin levels were negatively correlated with IL-6 levels. Fibronectin was a poor predictor of MCD. CONCLUSION:Plasma fibronectin levels are decreased in children with MCD, especially in shock and death. This decrease is associated with high IL-6 levels. Fibronectin could be a novel therapy in severe MCD.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Riordan FA,Bestwick K,Thomson AP,Sills JA,Hart CAdoi
10.1007/s004310050636subject
Has Abstractpub_date
1997-06-01 00:00:00pages
451-3issue
6eissn
0340-6199issn
1432-1076journal_volume
156pub_type
杂志文章,多中心研究abstract：INTRODUCTION:Prevention of obesity and overweight is an important target for health promotion. Early prevention requires an intervention during childhood and adolescence. At these stages, the game could be an appropriate means to teach nutrition knowledge and to influence dietary behaviour. To this end, the authors dev...
journal_title：European journal of pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00431-006-0153-9
更新日期：2006-09-01 00:00:00
abstract：UNLABELLED:Alleviation of suffering is considered to be one of the important goals of medical interventions. Understanding of what constitutes suffering in children admitted to a pediatric intensive care unit (PICU) is lacking. This study aims to assess perceptions by parents, doctors, and nurses of suffering in critic...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-014-2440-1
更新日期：2015-05-01 00:00:00
abstract：:The Dubowitz syndrome is a rare, autosomal, recessively inherited disorder of intrauterine and postnatal growth retardation leading to microcephaly, moderate mental retardation and such characteristic facial anomalies as telecanthus, epicanthic folds, blepharophimosis, ptosis, broadening of the bridge and tip of the n...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00496039
更新日期：1986-04-01 00:00:00
abstract：UNLABELLED:Fifty-two cases of childhood brucellosis which occurred in north-western Greece during the 15-year period 1979-1993, are reviewed. It is believed that they represent very closely the total incidence of the disease in the region which has a population of 100,000 children aged 0-14 years old. Brucellosis-affec...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02115616
更新日期：1996-01-01 00:00:00
abstract：:Iodine deficiency is well documented in Belgium in adults including pregnant women, adolescents, schoolchildren, and neonates, but no data are available in the age group 6 months-3 years. We investigated the status of iodine nutrition in 111 healthy subjects in this age group in an attempt to evaluate the risk of brai...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310000707
更新日期：2001-04-01 00:00:00
abstract：:Maternal morbidity is associated with cesarean deliveries. However, new evidence suggests that short- and long-term neonatal morbidity is also associated. This includes respiratory morbidity with conflicting results. To determine whether mode of delivery has an impact on the long-term risk for respiratory morbidity in...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-018-3225-8
更新日期：2018-11-01 00:00:00
abstract：:We examined the long-term outcome in 111 children who had convulsions during shigellosis and were followed for 3-18 years after the incident. No deaths or persistent motor deficits occurred as sequellae. Poor coordination of fine hand movements were noted in 3.3% of the 92 children who had no pre-existing neurological...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02106298
更新日期：1990-01-01 00:00:00
abstract：:To elucidate the basis for the recurrent infections in patients with glycogen storage disease (GSD) Ib we tested polymorphonuclear leukocyte (PMN) function in one patient. Bactericidal capacity and phagocytosis-induced O2 consumption were reduced. Also, phorbol myristate acetate-stimulated superoxide production and gl...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442674
更新日期：1983-09-01 00:00:00
abstract：UNLABELLED:An isolated eosinophilic granuloma involving the posterior elements of a lumbar vertebra is reported in a 3-year-old boy presenting with progressive limp. Radiological investigations revealed osteolysis of the L5 right pedicle. MRI showed a well-defined homogeneous mass with nonspecific signal intensity. An ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310051097
更新日期：1999-05-01 00:00:00
abstract：:Congenital adrenal hyperplasia (CAH) is an inherited metabolic disease caused by the deficiency of one of the enzymes necessary for cortisol synthesis. With carefully supervised medical treatment, CAH patients have the capacity for normal puberty and fertility. We report on a 12.4-year-old female who, because of the e...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-008-0847-2
更新日期：2009-07-01 00:00:00
abstract：UNLABELLED:Atypical hemolytic uremic syndrome (HUS) refers to the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury in the absence of Shiga toxin-producing Escherichia coli exposure or Streptococcus pneumoniae infection. Currently, approximately 50 % of the atypical cases have demons...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-012-1763-z
更新日期：2012-10-01 00:00:00
abstract：:To compare the efficacy of low dose fentanyl infusion and 24% oral sucrose in providing optimal pain relief during laser for retinopathy of prematurity (ROP), we enrolled fifty-eight spontaneously breathing preterm infants undergoing laser. The preterm infants were randomized to either fentanyl infusion (1 mcg/kg/hr) ...
journal_title：European journal of pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00431-019-03514-5
更新日期：2020-02-01 00:00:00
abstract：UNLABELLED:We report fives sporadic cases of hyperekplexia or startle disease characterized by a highly exaggerated startle reflex and tonic attacks. Affected neonates suffer from prolonged periods of stiffness and are at risk for sudden death from apnea. An early diagnosis is needed. Sudden loud sounds, unexpected tac...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-005-0015-x
更新日期：2006-02-01 00:00:00
abstract：:The Kabuki (Niikawa-Kuroki) syndrome was reported in 1981 by Niikawa et al. and Kuroki et al. in a total of ten unrelated Japanese children with a characteristic array of multiple congenital anomalies and mental retardation. The syndrome is characterized by a distinct face, mild to moderate mental retardation, postnat...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01983409
更新日期：1994-06-01 00:00:00
abstract：: ...
journal_title：European journal of pediatrics
pub_type： 信件
doi：10.1007/s00431-018-3259-y
更新日期：2019-01-01 00:00:00
abstract：:Metabolic liver diseases (MLD) are an important group of disorders presenting with neonatal cholestasis (NC). The spectrum of liver involvement is wide and the presumptive diagnosis is traditionally based on clinical and laboratory findings. Recently, next-generation sequencing (NGS) panels have emerged as an appealin...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-019-03328-5
更新日期：2019-04-01 00:00:00
abstract：:Recently a novel and non-invasive technique of lower leg length measurement (knemometry) was introduced. The method estimates the distance between heel and knee in the sitting child with an accuracy of 0.09 mm(SD). Two female patients with anorexia nervosa, aged 14:4 and 13:7 years, weighing minus 27 and minus 38% of ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02467353
更新日期：1987-11-01 00:00:00
abstract：:Retraction Note to: Eur J Pediatr (1994) 153:668-671 DOI 10.1007/BF02190689. This article, "Adenosine triphosphate treatment for supraventricular tachycardia in infants", published in the European Journal of Pediatrics (1994) 153/9: 668-671, Springer-Verlag 1994, has been retracted at the request of the Publisher as i...
journal_title：European journal of pediatrics
pub_type： 撤回出版物
doi：10.1007/s00431-015-2640-3
更新日期：2015-11-01 00:00:00
abstract：: ...
journal_title：European journal of pediatrics
pub_type： 信件
doi：10.1007/s00431-018-3217-8
更新日期：2018-11-01 00:00:00
abstract：:Three infants with severe combined immunodeficiency and adenosine deaminase (ADA) deficiency were treated by T-cell depleted bone marrow transplantation (BMT), using human leukocyte antigen (HLA)-haploidentical parents as donors. In the first patient, two initial transplants failed to engraft and no change of the immu...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01995857
更新日期：1989-11-01 00:00:00
abstract：UNLABELLED:Monitoring of therapy-related late effects after acute lymphoblastic leukaemia (ALL) therapy in childhood has become an increasingly important field in posttherapeutic patient surveillance. The usefulness of neurophysiological investigations (e.g. EEG, evoked potentials (EP)) as part of these attempts is con...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050700
更新日期：1997-09-01 00:00:00
abstract：:Familial hemophagocytic lymphohistiocytosis (FHL) is probably a genetically transmitted disease affecting infants and very young children. Cardinal symptoms are fever, hepatosplenomegaly, and pancytopenia. Frequently meningeal involvement is seen, manifested by neurologic symptoms and a lymphohistiocytic pleocytosis w...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF00443367
更新日期：1983-06-01 00:00:00
abstract：UNLABELLED:Scorpion envenomation is a health problem in children in tropical and subtropical regions. The aim of this study was to evaluate demographic and clinical characteristics as well as outcomes in referred children to Assiut University Children Hospital during the year 2012 with a history of scorpion sting. The ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-013-2244-8
更新日期：2014-06-01 00:00:00
abstract：:Adolescence obesity and depression are increasingly prevalent and are associated with various health complications. The aim of this study was to examine the association between weight status (normal weight, overweight, and obese) and depressive symptoms in adolescents and to explore the probable mediators, including o...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-012-1753-1
更新日期：2012-08-01 00:00:00
abstract：:A benign cystic nephroblastoma in a 6-month-old boy is presented. Erroneous interpretation as malignant nephroblastoma led to unnecessarily aggressive therapy. There is no evidence of recurrence or metastatic disease 12 years after the initial resection. As shown in our case and in the others previously reported in th...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00447474
更新日期：1979-05-18 00:00:00
abstract：:Chemically defined or elemental medical foods provide the majority of protein equivalent in the diets of children treated for phenylketonuria (PKU). Because of the restricted intake of high biologic value protein, children with PKU often have lower than normal plasma concentrations of ferritin and zinc. Few reported s...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/pl00014231
更新日期：1996-07-01 00:00:00
abstract：UNLABELLED:To determine bilirubin-induced neurotoxicity, serial visual evoked potentials (VEPs) of 72 infants with neonatal hyperbilirubinaemia and 22 controls were evaluated and compared in four sessions for 8 weeks after birth. The levels of maximal serum bilirubin were found positively related to the wave latencies ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02079073
更新日期：1995-08-01 00:00:00
abstract：:Two unique associations of disease with Escherichia coli O157:H7 are presented. These cases broaden the spectrum of disease associated with this organism which currently includes bloody and non-bloody diarrhoea, haemolytic-uraemic syndrome, and thrombotic thrombocytopenic purpura. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02106287
更新日期：1990-01-01 00:00:00
abstract：:Palivizumab utilization, compliance, and outcomes were examined in infants with preexisting medical diseases within the Canadian Registry Database (CARESS) to aid in developing guidelines for potential "at-risk" infants in the future. Infants who received ≥1 dose of palivizumab during the 2006-2010 respiratory syncyti...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-011-1654-8
更新日期：2012-05-01 00:00:00
abstract：:Serum immunoreactive erythropoietin (siEPO) was determined in cord serum from neonates (n = 97, gestational age 36-43 weeks), in healthy children from birth to adolescence (n = 260) and in children with haematological (n = 30), renal (n = 10) and congenital heart diseases (n = 70). In healthy children siEPO levels dec...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01959395
更新日期：1990-04-01 00:00:00
