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Glomerular filtration rate in the preterm infant: the relation to gestational and postnatal age.

Abstract：

:In 41 preterm neonates with a gestational age (GA) varying from 27 to 36 weeks, glomerular filtration rate (GFR) was measured by means of the continuous inulin infusion technique. The reliability of the technique was confirmed. During postnatal development GFR was found to increase in two ways: firstly, an increase with advancing gestational age, associated with the increase in body weight (BW) [GFR (ml/min) = 0.15 X GA-3.20, r = 0.48, P = 0.0048]; secondly, a postnatal increase, being independent from increment in BW. An increase in GFR (ml/min.kg) from 0.88 +/- 0.23 to 1.18 +/- 0.28 was observed between day 4 and day 11 postnatally (P less than 0.008). This latter increase is probably associated with changes in renal haemodynamics. No significant influence of artificial ventilation on GFR could be demonstrated in preterm neonates.

journal_name

Eur J Pediatr

journal_title

European journal of pediatrics

authors

van der Heijden AJ,Grose WF,Ambagtsheer JJ,Provoost AP,Wolff ED,Sauer PJ

doi

10.1007/BF00441807

subject

Has Abstract

pub_date

1988-10-01 00:00:00

pages

24-8

issue

1

eissn

0340-6199

issn

1432-1076

journal_volume

148

pub_type

杂志文章

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