Granulocyte colony-stimulating factor receptor expression on neutrophils of term and preterm neonates with and without signs of infection.

Abstract:

UNLABELLED:Neutrophils are an essential component of the human host defence system against infection. Recombinant human granulocyte colony-stimulating factor induces neutrophilia and enhances effector functions of mature neutrophils. Since the biological effects of granulocyte colony-stimulating factor (G-CSF) are mediated by its receptor, we investigated the expression of G-CSF receptor on the surface of neutrophils of term and preterm neonates (n = 22) with and without signs of infection and of healthy adults (n = 13) by flow cytometry. In healthy adults, the percentage of neutrophils expressing G-CSF receptor was higher compared to cord blood of term and preterm neonates (87% vs 53%, P < 0.05). Between 2 and 32 h of life, neonates with signs of infection showed lower values of G-CSF receptor expression compared to neonates without signs of infection (32% vs 54%, P < 0.05). No correlation was detectable between expression of G-CSF receptor and gestational age. CONCLUSION:Expression of granulocyte colony-stimulating factor receptor on neutrophils is lower than in adults. This may adversely affect granulopoiesis and neutrophil function during the neonatal period. Moreover, granulocyte colony-stimulating factor receptor expression seems to be down-regulated during neonatal infection.

journal_name

Eur J Pediatr

authors

Gessler P,Neu S,Nebe T,Speer CP

doi

10.1007/s004310051129

keywords:

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

497-500

issue

6

eissn

0340-6199

issn

1432-1076

journal_volume

158

pub_type

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