Fomepizole as a therapeutic strategy in paediatric methanol poisoning. A case report and review of the literature.

Abstract:

UNLABELLED:Methanol poisoning is not frequently observed in children; however, without treatment, serious intoxication can be complicated by visual impairment, coma, metabolic acidosis, respiratory and circulatory insufficiency and death. Treatment in a paediatric intensive care is therefore compulsory. Methanol is metabolised in the liver by alcohol dehydrogenase to the toxic metabolites formaldehyde and formic acid. Classically, ethanol is given as a competitive inhibitor in order to avoid the formation of these compounds. We report on the use of fomepizole (4-methylpyrazole),a new and potent inhibitor of alcohol dehydrogenase, in a 3-year-old boy after the intake of a toxic amount of methanol. The course was uneventful and the use of fomepizole was not accompanied by any side-effects. An overview is given of all cases of paediatric poisoning in which fomepizole was used. CONCLUSION:Fomepizole seems to be a safe and valid alternative to ethanol in cases of paediatric methanol poisoning.

journal_name

Eur J Pediatr

authors

De Brabander N,Wojciechowski M,De Decker K,De Weerdt A,Jorens PG

doi

10.1007/s00431-004-1588-5

keywords:

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

158-61

issue

3

eissn

0340-6199

issn

1432-1076

journal_volume

164

pub_type

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