Introduction of point-of-care neonatal lung ultrasound in a developing country.


:Despite neonatal lung ultrasound (LU) being diffused worldwide, its introduction in limited-resource areas has not been formally investigated. We conceived a project to introduce it in a level 3 NICU of a developing country and verify if, after a short protocolized training, clinicians may efficaciously use LU. Inter-rater agreement between ultrasound trainees and trainers was analyzed within both the local test and the diffusion phases of the project. High inter-rater agreements were found between expert trainers and the two neonatologists who were trained in a skilled European center (Cohen's Kappa, 0.951; 95%CI, 0.882-0.999), as well as between the two and the second round of locally trained colleagues (Cohen's Kappa, 0.896; 95%CI, 0.797-0.996). Moreover, a high agreement was found between the clinical respiratory diagnosis (used as the "gold standard") and the LU diagnosis given by the first two trainees (intraclass correlation, 0.992; 95%CI, 0.987-0.996) and the locally trained physicians (intraclass correlation, 0.97; 95%CI, 0.95-0.98). A final survey demonstrated that the project was perceived as efficacious and that LU was going to be integrated into routine clinical practice.Conclusions: А short LU training provided sufficient proficiency and allowed the LU introduction in clinical practice in the neonatal intensive care unit in a developing country.What is Known:• Lung ultrasound is a promising technique for evaluating neonatal respiratory distress at least in high-income countries. Previous studies revealed high specificity and sensitivity in diagnosing specific neonatal disorders.• An important barrier to the more extensive use of lung ultrasound in neonatal critical care is a lack of efficient and suitable training solutions.What is New:• Descriptive LU performed by neonatologist in a developing country after a short formal training is feasible with good quality.• A short formal LU training program provided good proficiency and allowed a correct descriptive diagnosis in a neonatal unit in a developing country.


Eur J Pediatr


Mazmanyan P,Kerobyan V,Shankar-Aguilera S,Yousef N,De Luca D




Has Abstract


2020-07-01 00:00:00














  • Absence epilepsy of early childhood--genetic aspects.

    abstract::Clinical and EEG family data of 140 cases with early childhood epilepsy with absences are presented. The aim of the study was to evaluate, whether the occurrence of generalized tonic clonic seizures (GTCS) as a presenting symptom might correlate with family data, i.e. whether there are indications of heterogeneity. On...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Doose H

    更新日期:1994-05-01 00:00:00

  • Severe tick-borne encephalitis following passive immunization.

    abstract:UNLABELLED:We report on a 5-year-old girl with an unusually severe course of tick-borne encephalitis following passive immunization with specific hyperimmune globulin after a tick bite in an endemic area. Serial investigations of the CSF revealed intrathecal production of specific antibodies paralleled by increasing nu...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Waldvogel K,Bossart W,Huisman T,Boltshauser E,Nadal D

    更新日期:1996-09-01 00:00:00

  • Doppler evaluation of renal blood flow velocity as a predictive index of acute renal failure in perinatal asphyxia.

    abstract:UNLABELLED:Aim of our study was to evaluate Doppler renal blood flow velocity in asphyxiated neonates and to correlate renal function to Doppler findings. Doppler renal blood flow velocity was evaluated in 23 severely asphyxiated neonates born at a gestational age > 32 weeks and compared to our standard Doppler data ob...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Luciano R,Gallini F,Romagnoli C,Papacci P,Tortorolo G

    更新日期:1998-08-01 00:00:00

  • Portal vein thrombosis after splenectomy for hereditary stomatocytosis in childhood.

    abstract:UNLABELLED:Portal vein thrombosis is a rare but potentially lethal complication in children requiring splenectomy. We report on a 15-year-old boy with a dehydrated hereditary stomatocytosis, who underwent splenectomy and presented a postoperative partial portal vein thrombosis. With prompt heparin therapy, neither prop...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Perel Y,Dhermy D,Carrere A,Chateil JF,Bondonny JM,Micheau M,Barbier R

    更新日期:1999-08-01 00:00:00

  • Recombinant human interferon-gamma in patients with chronic granulomatous disease--European follow up study.

    abstract::This was an uncontrolled, open-label follow up study of a previous 12-month, randomized, double-blind, placebo-controlled trial performed to assess the long-term efficacy and safety of Recombinant Human Interferon Gamma (rIFN-gamma) in patients with chronic granulomatous disease (CGD). In two centres, 28 patients (24 ...

    journal_title:European journal of pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Weening RS,Leitz GJ,Seger RA

    更新日期:1995-04-01 00:00:00

  • What's new in metabolic and genetic hypoglycaemias: diagnosis and management.

    abstract::Hypoglycaemia in children can be a life-threatening situation that needs to be assessed rigorously in order to treat efficiently and avoid relapse that can be responsible for cerebral damage. The diagnosis of impairment in glucose homeostasis requires the knowledge of the mechanisms regulating blood glucose concentrat...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审


    authors: Valayannopoulos V,Romano S,Mention K,Vassault A,Rabier D,Polak M,Robert JJ,de Keyzer Y,de Lonlay P

    更新日期:2008-03-01 00:00:00

  • Dopamine versus epinephrine for fluid-refractory septic shock in neonates.

    abstract:: ...

    journal_title:European journal of pediatrics

    pub_type: 评论,信件


    authors: Sasidharan R,Gupta N,Chawla D

    更新日期:2019-01-01 00:00:00

  • Inconsistencies in the management of neonates born to mothers with "thyroid diseases".

    abstract::Although thyroid medications are frequently prescribed during pregnancy, paediatricians treating the respective neonates often have no information about the underlying maternal thyroid disease, and inconsistencies in postnatal diagnostics may result. We analysed a cohort of 1819 mothers admitted for delivery in 1 year...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Weissenfels PC,Woelfle J,Korsch E,Joergens M,Gohlke B

    更新日期:2018-11-01 00:00:00

  • Iodine deficiency during infancy and early childhood in Belgium: does it pose a risk to brain development?

    abstract::Iodine deficiency is well documented in Belgium in adults including pregnant women, adolescents, schoolchildren, and neonates, but no data are available in the age group 6 months-3 years. We investigated the status of iodine nutrition in 111 healthy subjects in this age group in an attempt to evaluate the risk of brai...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Delange F,Wolff P,Gnat D,Dramaix M,Pilchen M,Vertongen F

    更新日期:2001-04-01 00:00:00

  • Oesophageal pH monitoring and reflux oesophagitis in irritable infants.

    abstract:UNLABELLED:Acid reflux and/or oesophagitis may be responsible for inconsolable crying in infants. We evaluated prospectively the presence of acid reflux disease, oesophagitis and the accuracy of pH monitoring in the prediction of oesophagitis in a population of irritable infants. A 24-h oesophageal pH monitoring with a...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Vandenplas Y,Badriul H,Verghote M,Hauser B,Kaufman L

    更新日期:2004-06-01 00:00:00

  • A national educational campaign to raise awareness of child physical abuse among health care professionals.

    abstract::Education is necessary to improve child physical abuse detection and management. A few studies have described national child abuse training programs, but none has measured changes in knowledge among participants. A collaboration of child abuse experts from the USA, an academic pediatric department, and a non-governmen...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Soldatou A,Stathi A,Panos A,Paouri B,Koutsoukou E,Krepis P,Tsolia M,Oral R,Leventhal JM

    更新日期:2020-09-01 00:00:00

  • Beneficial effects of creatine phosphate sodium for the treatment of Henoch-Schönlein purpura in patients with early renal damage detected using urinary kidney injury molecule-1 levels.

    abstract:UNLABELLED:Henoch-Schönlein purpura (HSP) is a small-vessel disease in children that is often accompanied by kidney damage. Despite many efforts to improve the early assessment of renal injury in HSP patients, effective markers are still lacking. In recent years, the relationship between kidney injury molecule-1 (KIM-1...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Zhang J,Zeng H,Wang N,Tian X,Dou W,Shi P

    更新日期:2016-01-01 00:00:00

  • Utility and applicability of the "Childhood Obesity Risk Evaluation" (CORE)-index in predicting obesity in childhood and adolescence in Greece from early life: the "National Action Plan for Public Health".

    abstract::Early identification of infants being at high risk to become obese at their later childhood or adolescence can be of vital importance in any obesity prevention initiative. The aim of the present study was to examine the utility and applicability of the "Childhood Obesity Risk Evaluation (CORE)" index as a screening to...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Manios Y,Vlachopapadopoulou E,Moschonis G,Karachaliou F,Psaltopoulou T,Koutsouki D,Bogdanis G,Carayanni V,Hatzakis A,Michalacos S

    更新日期:2016-12-01 00:00:00

  • Plasma fibronectin concentrations in healthy newborns and in children.

    abstract::Plasma fibronectin (FN) concentrations were measured by an immunonephelometric method in cord blood from 76 healthy newborns (45 full term and 31 preterm), in 181 healthy children, from 1 month-15 years old, divided by age into seven groups and in 81 control adults. FN levels in newborns were 35% of those of adults. T...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Valletta EA,Bonazzi L,Zuanazzi R,Del Col G,Andreoli A,Stocchero L,Boner AL

    更新日期:1988-01-01 00:00:00

  • Nicotine and cotinine concentrations in the milk of smoking mothers: influence of cigarette consumption and diurnal variation.

    abstract::The relationship between nicotine and cotinine concentrations in mother's milk (including 24 h profiles) and the number of cigarettes consumed was studied. A total of 206 milk samples were collected from 34 nursing, smoking mothers. The mothers were distributed into three groups: Group I (1-10 cigarettes/day), group I...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Luck W,Nau H

    更新日期:1987-01-01 00:00:00

  • "Negative growth" in anorexia nervosa assessed by knemometry.

    abstract::Recently a novel and non-invasive technique of lower leg length measurement (knemometry) was introduced. The method estimates the distance between heel and knee in the sitting child with an accuracy of 0.09 mm(SD). Two female patients with anorexia nervosa, aged 14:4 and 13:7 years, weighing minus 27 and minus 38% of ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Hermanussen M,Geiger-Benoit K,Sippell WG

    更新日期:1987-11-01 00:00:00

  • Trichothiodystrophy without photosensitivity. Biochemical, ultrastructural and DNA repair studies.

    abstract::A case of trichothiodystrophy (TTD) without photosensitivity is reported in an 8-year-old girl. Electron microscopic (EM) examination of the keratinocytes showed fibrillary bundles in the cytoplasm thinner and less electron dense than those of the normal cells and large membrane-bound vacuoles filled with granular-fil...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Fois A,Balestri P,Calvieri S,Zampetti M,Giustini S,Stefanini M,Lagomarsini P

    更新日期:1988-05-01 00:00:00

  • Urinary potassium to urinary potassium plus sodium ratio can accurately identify hypovolemia in nephrotic syndrome: a provisional study.

    abstract::There is evidence pointing to a decrease of the glomerular filtration rate (GFR) in a subgroup of nephrotic children, likely secondary to hypovolemia. The aim of this study is to validate the use of urinary potassium to the sum of potassium plus sodium ratio (UK/UK+UNa) as an indicator of hypovolemia in nephrotic synd...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Keenswijk W,Ilias MI,Raes A,Donckerwolcke R,Walle JV

    更新日期:2018-01-01 00:00:00

  • Effects of red cell transfusion on pulmonary blood flow and right ventricular systolic time intervals in neonates.

    abstract:UNLABELLED:Blood transfusion increases blood volume and blood viscosity of the neonate. Since both volume expansion and increase in blood viscosity may be associated with increased pulmonary artery pressure, we studied effects of transfusion (10 ml of red blood cells per kilogramme of body weight) on right ventricular ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Nelle M,Hoecker C,Linderkamp O

    更新日期:1997-07-01 00:00:00

  • Formula feeding increases the risk of antibiotic prescriptions in children up to 2 years: results from a cohort study.

    abstract::Association between the use of infant formula and risks for infants' health is seldom studied in western countries. We set up a historical cohort based on record linkage analysis, combining the data from administrative databases providing individual data. Infants receiving the second dose of pediatric immunization bet...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Di Mario S,Gagliotti C,Donatini A,Battaglia S,Buttazzi R,Balduzzi S,Borsari S,Basevi V,Barbieri L,and the Regional breastfeeding monitoring group.

    更新日期:2019-12-01 00:00:00

  • Idiopathic male pseudohermaphroditism is associated with prenatal growth retardation.

    abstract:UNLABELLED:About 50% of intersex cases are due to male pseudohermaphroditism, and of these cases, 50% are not clarified aetiologically. The association of idiopathic male pseudohermaphroditism and prenatal growth retardation has been recently reported. The aim of this study was to verify whether there was a difference ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: de Andrade Machado Neto F,Moreno Morcillo A,Trevas Maciel-Guerra A,Guerra-Junior G

    更新日期:2005-05-01 00:00:00

  • Multifocal infantile hepatic hemangiomas--imaging strategy and response to treatment after propranolol and steroids including review of the literature.

    abstract::Infantile hepatic hemangioma is the most common benign liver tumor during infancy. Prompt diagnosis and timely institution of therapy are of utmost importance. Magnetic resonance imaging (MRI) plays a key role in the correct diagnosis and monitoring of treatment. We report on a 15-week-old girl with multifocal infanti...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审


    authors: Bosemani T,Puttgen KB,Huisman TA,Tekes A

    更新日期:2012-07-01 00:00:00

  • Evaluation of the indications for early exchange transfusion in rhesus haemolytic disease during phototherapy.

    abstract::The study material consisted of 251 newborn light-treated infants with rhesus haemolytic disease (RHD) caused by anti-D. 139 infants were treated with ordinary phototherapy (white single light) and 112 infants with intensive phototherapy (blue double light). An evaluation was made as to wheter the indications for earl...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Ebbesen F

    更新日期:1980-01-01 00:00:00

  • Untreated congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

    abstract::Congenital adrenal hyperplasia (CAH) is an inherited metabolic disease caused by the deficiency of one of the enzymes necessary for cortisol synthesis. With carefully supervised medical treatment, CAH patients have the capacity for normal puberty and fertility. We report on a 12.4-year-old female who, because of the e...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Tahirovic H,Toromanovic A,Grubic M,Grubic Z,Dumic K

    更新日期:2009-07-01 00:00:00

  • Predicting length-of-stay in preterm neonates.

    abstract:UNLABELLED:In neonatology, the early prediction of length-of-stay (LOS) may help in decision making. We retrospectively studied the accuracy of two LOS prediction models, namely a multiple linear regression model (MR) and an artificial neural network (ANN). Preterm neonates (n = 2144) were randomly assigned to a traini...

    journal_title:European journal of pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Zernikow B,Holtmannspötter K,Michel E,Hornschuh F,Groote K,Hennecke KH

    更新日期:1999-01-01 00:00:00

  • COVID-19 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents: a systematic review of critically unwell children and the association with underlying comorbidities.

    abstract::Data show that children are less severely affected with SARS-Covid-19 than adults; however, there have been a small proportion of children who have been critically unwell. In this systematic review, we aimed to identify and describe which underlying comorbidities may be associated with severe SARS-CoV-2 disease and de...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审


    authors: Williams N,Radia T,Harman K,Agrawal P,Cook J,Gupta A

    更新日期:2020-09-10 00:00:00

  • The use of ethanol in paediatric formulations in New Zealand.

    abstract:UNLABELLED:Children's right to access safe and effective medicines is recognised globally. Ethanol, used in paediatric liquid formulations as a solvent and preservative, is associated with safety concerns with respect to both acute ingestion and chronic exposure. In addition, families may have cultural or religious val...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Svirskis D,Toh M,Ram S

    更新日期:2013-07-01 00:00:00

  • Failed detection of complex congenital heart disease (including double outlet right ventricle and total anomalous pulmonary venous return) by neonatal pulse oximetry screening.

    abstract::We report on a newborn infant with complex congenital heart disease (CHD) featuring double outlet right ventricle and hypoplastic left ventricle who had postductal oxygen saturation well above 95% and thus eluded pulse oximetry screening for CHD. ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Hetzel PG,Glanzmann R,Günthard J,Bruder E,Godi E,Bührer C

    更新日期:2007-06-01 00:00:00

  • On the influence of age on immunity in Down's syndrome.

    abstract::In 23 subjects of different ages with Down's syndrome a number of parameters of non-specific defense of humoral and cellular immunity were investigated. While in all age groups complement factors C3, C4 and C5 as well as phagocytosis and NBT indices were in the normal range, a dysgammaglobulinaemia increasing with age...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Seger R,Buchinger G,Ströder J

    更新日期:1977-01-26 00:00:00

  • Management of neurogenic bladder dysfunction secondary to myelomeningocele.

    abstract::We investigated 55 children, aged from 24 months to 14 years with neurogenic bladder dysfunction secondary to myelomeningocele, by serial urodynamic. They were serially evaluation over 2-5 years. Management consisted of drug therapy together with intermittent vesical catheterization in different combinations on the ba...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Castro-Gago M,Novo I,Cimadevila A,Peña J,Rodriguez-Núñez A,Marqués'-Queimadelos A

    更新日期:1990-11-01 00:00:00