Introduction of point-of-care neonatal lung ultrasound in a developing country.

Abstract:

:Despite neonatal lung ultrasound (LU) being diffused worldwide, its introduction in limited-resource areas has not been formally investigated. We conceived a project to introduce it in a level 3 NICU of a developing country and verify if, after a short protocolized training, clinicians may efficaciously use LU. Inter-rater agreement between ultrasound trainees and trainers was analyzed within both the local test and the diffusion phases of the project. High inter-rater agreements were found between expert trainers and the two neonatologists who were trained in a skilled European center (Cohen's Kappa, 0.951; 95%CI, 0.882-0.999), as well as between the two and the second round of locally trained colleagues (Cohen's Kappa, 0.896; 95%CI, 0.797-0.996). Moreover, a high agreement was found between the clinical respiratory diagnosis (used as the "gold standard") and the LU diagnosis given by the first two trainees (intraclass correlation, 0.992; 95%CI, 0.987-0.996) and the locally trained physicians (intraclass correlation, 0.97; 95%CI, 0.95-0.98). A final survey demonstrated that the project was perceived as efficacious and that LU was going to be integrated into routine clinical practice.Conclusions: А short LU training provided sufficient proficiency and allowed the LU introduction in clinical practice in the neonatal intensive care unit in a developing country.What is Known:• Lung ultrasound is a promising technique for evaluating neonatal respiratory distress at least in high-income countries. Previous studies revealed high specificity and sensitivity in diagnosing specific neonatal disorders.• An important barrier to the more extensive use of lung ultrasound in neonatal critical care is a lack of efficient and suitable training solutions.What is New:• Descriptive LU performed by neonatologist in a developing country after a short formal training is feasible with good quality.• A short formal LU training program provided good proficiency and allowed a correct descriptive diagnosis in a neonatal unit in a developing country.

journal_name

Eur J Pediatr

authors

Mazmanyan P,Kerobyan V,Shankar-Aguilera S,Yousef N,De Luca D

doi

10.1007/s00431-020-03603-w

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

1131-1137

issue

7

eissn

0340-6199

issn

1432-1076

pii

10.1007/s00431-020-03603-w

journal_volume

179

pub_type

杂志文章
  • Metabolic liver diseases presenting with neonatal cholestasis: at the crossroad between old and new paradigms.

    abstract::Metabolic liver diseases (MLD) are an important group of disorders presenting with neonatal cholestasis (NC). The spectrum of liver involvement is wide and the presumptive diagnosis is traditionally based on clinical and laboratory findings. Recently, next-generation sequencing (NGS) panels have emerged as an appealin...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-019-03328-5

    authors: Moreira-Silva H,Maio I,Bandeira A,Gomes-Martins E,Santos-Silva E

    更新日期:2019-04-01 00:00:00

  • Periventricular leucomalacia: a review.

    abstract:UNLABELLED:Periventricular leucomalacia is a condition that causes lifelong disability and considerable economic burden. It occurs in premature infants of less than 32 weeks gestation due to their unique anatomical features. The white matter of these infants is poorly vascularised and contains oligodendrocyte progenito...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00431-004-1477-y

    authors: Blumenthal I

    更新日期:2004-08-01 00:00:00

  • Chronic granulomatous disease of childhood: gastric manifestation and response to salazosulfapyridine therapy.

    abstract::The case history of a 10-year-old boy with chronic granulomatous disease (CGD) and gastric obstruction is presented. First abdominal symptoms occurred at 4 years of age when antral narrowing was detected. Due to unresponsiveness to antibiotic and steroid treatment, salazosulfapyridine therapy was initiated. Objective ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02024330

    authors: Stopyrowa J,Fyderek K,Sikorska B,Kowalczyk D,Zembala M

    更新日期:1989-10-01 00:00:00

  • Neonatal pneumothorax drainage systems: in vitro evaluation.

    abstract::We studied, in vitro, different commercially available components for pneumothorax drainage, i.e. drainage tubes, Heimlich flutter valve and vacuum control units. The drainage of a pneumothorax by a drainage tube was, as expected, directly dependent on Poiseuille's law and was influenced more by diameter than length. ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02024337

    authors: Bakker JC,Liem M,Wijnands JB,Karsdon J,Berger HM

    更新日期:1989-10-01 00:00:00

  • Prevalence of iron deficiency and related factors in Spanish adolescents.

    abstract::Iron deficiency anaemia continues to be the world's most important cause of years lived with disability in children and adolescents. Assessment of iron deficiency traditionally depended on laboratory parameters that may be modified by inflammation states, including obesity, which is nowadays a current condition in ado...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-020-03651-2

    authors: Ibáñez-Alcalde MM,Vázquez-López MÁ,López-Ruzafa E,Lendínez-Molinos FJ,Bonillo-Perales A,Parrón-Carreño T

    更新日期:2020-10-01 00:00:00

  • Fatty acid composition of human milk during the 1st month after term and preterm delivery.

    abstract:UNLABELLED:The fatty acid composition of human breast milk was determined longitudinally after term and preterm delivery by high resolution gas liquid chromatography. Milk samples were obtained at days 5, 10, 20 and 30 after term (n = 38) or preterm (n = 19) delivery. The saturated fatty acids C10:0 and C12:0 and the p...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s004310050573

    authors: Genzel-Boroviczény O,Wahle J,Koletzko B

    更新日期:1997-02-01 00:00:00

  • Somatomedin-binding proteins: what role do they play in the growth process?

    abstract::The insulin-like growth factors (IGF-I and IGF-II) circulate bound to specific proteins. Two classes of binding proteins have been relatively well characterized differing in size, immunological activity, and physiological function. This review summarizes the more recent data on IGF-binding proteins, focusing on their ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/BF01995850

    authors: Cianfarani S,Holly JM

    更新日期:1989-11-01 00:00:00

  • Analysis of medication prescribing errors in critically ill children.

    abstract:UNLABELLED:Medication prescribing errors (MPE) can result in serious consequences for patients. In order to reduce errors, we need to know more about the frequency, the type and the severity of such errors. We therefore performed a prospective observational study to determine the number and type of medication prescribi...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-015-2542-4

    authors: Glanzmann C,Frey B,Meier CR,Vonbach P

    更新日期:2015-10-01 00:00:00

  • Maternal use of prednisolone is unlikely to be associated with neonatal adrenal suppression-a single-center study of 16 cases.

    abstract::The use of supra-physiological, exogenous corticosteroids in pregnancy may lead to neonatal adrenal suppression. We report on a single-center, case series study carried out between 2006 and 2014, which included all newborns (n = 16) of mothers using prednisolone ≥10 mg/day during pregnancy. Newborns were routinely ass...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-017-2949-1

    authors: de Vetten L,van Stuijvenberg M,Kema IP,Bocca G

    更新日期:2017-08-01 00:00:00

  • Haemorrhagic diathesis as a possible early sign of hereditary fructose intolerance.

    abstract::An infant girl three weeks of age with the leading symptom of skin haemorrhages is presented. On further investigation, the signs of severe hepatic damage with hypofibrinogenaemia and prothrombin complex impairment, and renal tubular dysfunction were disclosed. All these pathological symptoms, which were reversed on f...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00465567

    authors: Hosková A,Mrskos A

    更新日期:1977-12-30 00:00:00

  • Neurological complications of pandemic influenza A H1N1 2009 infection: European case series and review.

    abstract::Neurological manifestations and outcomes of children with the 2009 H1N1 virus infection have been reported in three American series and from smaller cohorts and case reports worldwide. Of the 83 children admitted between April 2009 and March 2010 with H1N1 virus infection to a tertiary children's hospital in a Europea...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00431-010-1392-3

    authors: Surana P,Tang S,McDougall M,Tong CY,Menson E,Lim M

    更新日期:2011-08-01 00:00:00

  • Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study.

    abstract::Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statist...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-020-03572-0

    authors: Herting E,Kribs A,Härtel C,von der Wense A,Weller U,Hoehn T,Vochem M,Möller J,Wieg C,Roth B,Göpel W,German Neonatal Network (GNN).

    更新日期:2020-08-01 00:00:00

  • Arginine-vasopressin in neonates with vasodilatory shock after cardiopulmonary bypass.

    abstract:UNLABELLED:Successful therapy of vasodilatory shock in adults and children with arginine-vasopressin (AVP) has been reported previously. Data on the use of vasopressin in neonates is limited. This retrospective study reports the effects of AVP-treatment in neonates with catecholamine-resistant systemic vasodilatation a...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-006-0400-0

    authors: Lechner E,Hofer A,Mair R,Moosbauer W,Sames-Dolzer E,Tulzer G

    更新日期:2007-12-01 00:00:00

  • Tuberculin skin test in bacille Calmette-Guérin-vaccinated children: how should we interpret the results?

    abstract:BACKGROUND:The tuberculin skin test (TST) is the most useful method for the diagnosis of tuberculosis (TB). There is no evidence about the effect of bacillus Calmette-Guerin (BCG) vaccine on the interpretation of TST results. OBJECTIVE:The aim of this study was to evaluate TST results in a population of immigrants and...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-012-1783-8

    authors: Piñeiro R,Mellado MJ,Cilleruelo MJ,García-Ascaso M,Medina-Claros A,García-Hortelano M

    更新日期:2012-11-01 00:00:00

  • A glycine 375-to-cysteine substitution in the transmembrane domain of the fibroblast growth factor receptor-3 in a newborn with achondroplasia.

    abstract::Achondroplasia, the most common form of chondrodysplasia, has been associated with mutations in the gene of the fibroblast growth factor receptor-3 (FGFR-3) on chromosome 4p. All 39 achondroplasia alleles studied so far carried point mutations which caused the same amino acid exchange, a substitution of glycine by arg...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01954274

    authors: Superti-Furga A,Eich G,Bucher HU,Wisser J,Giedion A,Gitzelmann R,Steinmann B

    更新日期:1995-03-01 00:00:00

  • Schistosomiasis in German children.

    abstract:UNLABELLED:Reports on schistosomiasis in children growing up in Europe are rare despite increased travel activity. We report on eight male and three female German children aged 50 months to 15 years with schistosomiasis. Six children were asymptomatic, whereas two presented with typical signs of Katayama fever. Persist...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s004310051326

    authors: Bialek R,Knobloch J

    更新日期:2000-07-01 00:00:00

  • Changes in red cell phosphate metabolism of preterm and fullterm infants with perinatal problems during their first month of life.

    abstract::The effects of perinatal problems on red cell phosphate metabolism were studied in two groups of infants (preterms B and fullterms D) during the first month of life. All infants started milk feeding from day three after birth. The results were compared to those of healthy preterms (A) and fullterms (C), respectively. ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-007-0464-5

    authors: Cholevas V,Challa A,Lapatsanis PD,Andronikou S

    更新日期:2008-02-01 00:00:00

  • Screening for cystic fibrosis in New York State: considerations for algorithm improvements.

    abstract:UNLABELLED:Newborn screening for cystic fibrosis (CF), a chronic progressive disease affecting mucus viscosity, has been beneficial in both improving life expectancy and the quality of life for individuals with CF. In New York State from 2007 to 2012 screening for CF involved measuring immunoreactive trypsinogen (IRT) ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-015-2616-3

    authors: Kay DM,Maloney B,Hamel R,Pearce M,DeMartino L,McMahon R,McGrath E,Krein L,Vogel B,Saavedra-Matiz CA,Caggana M,Tavakoli NP

    更新日期:2016-02-01 00:00:00

  • The painful hip: evaluation of criteria for clinical decision-making.

    abstract:UNLABELLED:Children with a painful hip present a diagnostic challenge since clinical differentiation between septic arthritis, transient synovitis and Perthes disease may be difficult. Septic arthritis, a potentially life-threatening and debilitating medical emergency, requires early recognition for successful treatmen...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s004310051243

    authors: Eich GF,Superti-Furga A,Umbricht FS,Willi UV

    更新日期:1999-11-01 00:00:00

  • Congenital hypothyroidism caused by a novel homozygous mutation in the thyroglobulin gene.

    abstract:UNLABELLED:Congenital hypothyroidism (CH) due to thyroglobulin (TG) deficit is an autosomal recessive disease (OMIM #274700) characterized by hypothyroidism, goiter, low serum TG, and a negative perchlorate discharge test. The aim of this study was to perform the genetic analysis of the TG gene in two sisters born from...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-013-1976-9

    authors: Agretti P,De Marco G,Di Cosmo C,Ferrarini E,Montanelli L,Bagattini B,Vitti P,Tonacchera M

    更新日期:2013-07-01 00:00:00

  • Hip effusion in nephrotic syndrome mimicking septic arthritis.

    abstract::A case of painful bilateral hip effusions resolving spontaneously in the diuretic phase of steroid responsive nephrotic syndrome in a 6-year-old girl is reported. ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02072499

    authors: Gupta S,Nirmal JM,Lennox CM

    更新日期:1993-02-01 00:00:00

  • Rubinstein-Taybi syndrome in a mother and son.

    abstract::The Rubinstein-Taybi syndrome is a condition characterized by mental retardation, typical facial changes and broad thumbs and big toes. The cause is unknown; almost all cases are sporadic. We describe a mother and son with Rubinstein-Taybi syndrome. Literature search documented at least 413 cases with 558 sibs. An aff...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00595907

    authors: Hennekam RC,Lommen EJ,Strengers JL,Van Spijker HG,Jansen-Kokx TM

    更新日期:1989-02-01 00:00:00

  • Tracheal bronchus associated with VACTERL.

    abstract:UNLABELLED:Tracheal bronchus (TB) associated with VACTERL has not been reported previously. A 5-month-old girl with VACTERL association was ventilator-dependent following surgical closure of a patent ductus arteriosus (PDA). Chest radiographs showed persistent hyperinflation of the right upper lobe. Bronchoscopy showed...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-002-1109-3

    authors: Kairamkonda V,Thorburn K,Sarginson R

    更新日期:2003-03-01 00:00:00

  • Concanavalin A capping in polymorphonuclear leukocytes.

    abstract::Various polymorphonuclear leukocyte (PMN) functions are dependent on an intact intracellular cytoskeleton consisting of the microtubules and the microfilaments. To investigate the microtublule system in PMNs we observed the spontaneous, Colchicine and Diamide induced cap-formation by fluorescence microscopy ion PMNs o...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00441634

    authors: Rister M,Brucke G,Wegener F,Gladtke E

    更新日期:1980-12-01 00:00:00

  • A new hereditary bone dysplasia with characteristic bowing and thickening of the distal ulna.

    abstract::An autosomal dominant hereditary bone dysplasia was observed in three members of a Sardinian family living in Germany--the father and two sons. The guiding clinical symptom is thickening of the wrist proximal to the styloid process of the ulna. The radiologically recognizable changes--non-calcified cartilaginous islan...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00441850

    authors: Rosenberg E,Löhr H

    更新日期:1986-04-01 00:00:00

  • Persistent pulmonary hypertension after lithium intoxication in the newborn.

    abstract::A case of lithium intoxication in the newborn is presented. Besides displaying extreme hypotonia and a goitre, the infant developed symptoms of congenital heart disease immediately after birth. Cardiac catheterization and angiocardiography revealed an elevated pulmonary vascular resistance and indicated that the cardi...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00442508

    authors: Filtenborg JA

    更新日期:1982-07-01 00:00:00

  • Perlman and Wiedemann-Beckwith syndromes: two distinct conditions associated with Wilms' tumour.

    abstract::Though children with Perlman and Wiedemann-Beckwith syndromes have a number of features in common, the two conditions are probably separate entities. The distinction may not always be easy, however, partly because of the extreme rarity of Perlman syndrome, only nine cases of which have been reported so far. We report ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01954125

    authors: Grundy RG,Pritchard J,Baraitser M,Risdon A,Robards M

    更新日期:1992-12-01 00:00:00

  • Epilepsy: knowledge and attitudes of physiotherapists, occupational therapists, and speech therapists.

    abstract::Physiotherapists, occupational therapists, and speech therapists play a key role in the treatment of children with epilepsy. We performed a survey of therapists' knowledge of and attitudes towards epilepsy in two regions of Germany, the city of Leipzig and the rural district of Zwickau. Therapists of 29/68 (43%) outpa...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-019-03437-1

    authors: Hackel K,Neininger MP,Kiess W,Bertsche T,Bertsche A

    更新日期:2019-10-01 00:00:00

  • Hepatotoxicity of rifampicin and isoniazid in children treated for tuberculosis.

    abstract::In order to determine the hepatotoxicity of rifampicin in children treated for tuberculosis, a survey was performed of 18 children receiving this medicine in combination with isoniazid. Fifteen of the 18 children (83%) showed a rise in ASAT values and 11 (61%) in ALAT values exceeding 29U/L. Seven children with maxima...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00441477

    authors: Linna O,Uhari M

    更新日期:1980-09-01 00:00:00

  • Severe hypothyroidism after contrast enema in premature infants.

    abstract::Premature newborns are particularly vulnerable to iatrogenic hypothyroidism due to iodine exposure, usually through skin absorption of iodine-containing disinfectants or intravenous administration of iodinated contrast agents. We report here a case of severe iatrogenic hypothyroidism with goiter and cholestasis, disco...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-008-0782-2

    authors: Lombard F,Dalla-Vale F,Veyrac C,Plan O,Cambonie G,Picaud JC

    更新日期:2009-04-01 00:00:00