Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study.

Abstract:

:Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statistically significant differences in weight, length or neurodevelopmental outcome (Bayley II scores) were found between the LISA intervention group (n = 95) and the control group (n = 84) that received standard treatment.Conclusion: No differences in outcome were observed at 2 years. LISA seems safe in that aspect. What is Known: • LISA is a method that is in increasing use for surfactant delivery to spontaneously breathing infants. LISA reduces the need for mechanical ventilation. What is New: • Outcome data at 2 years from the first randomized study with LISA raise no safety concerns in comparison to a group of infants that received standard treatment.

journal_name

Eur J Pediatr

authors

Herting E,Kribs A,Härtel C,von der Wense A,Weller U,Hoehn T,Vochem M,Möller J,Wieg C,Roth B,Göpel W,German Neonatal Network (GNN).

doi

10.1007/s00431-020-03572-0

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

1309-1313

issue

8

eissn

0340-6199

issn

1432-1076

pii

10.1007/s00431-020-03572-0

journal_volume

179

pub_type

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