Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study.


:Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statistically significant differences in weight, length or neurodevelopmental outcome (Bayley II scores) were found between the LISA intervention group (n = 95) and the control group (n = 84) that received standard treatment.Conclusion: No differences in outcome were observed at 2 years. LISA seems safe in that aspect. What is Known: • LISA is a method that is in increasing use for surfactant delivery to spontaneously breathing infants. LISA reduces the need for mechanical ventilation. What is New: • Outcome data at 2 years from the first randomized study with LISA raise no safety concerns in comparison to a group of infants that received standard treatment.


Eur J Pediatr


Herting E,Kribs A,Härtel C,von der Wense A,Weller U,Hoehn T,Vochem M,Möller J,Wieg C,Roth B,Göpel W,German Neonatal Network (GNN).




Has Abstract


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  • Gender differences in newborn subcutaneous fat distribution.

    abstract:UNLABELLED:The pattern and distribution of subcutaneous fat in term and preterm newborns has been assessed by skinfold thicknesses (ST), describing gender and gestational age variations. Weight, length and ST (triceps, biceps, subscapular and suprailiac) were measured in 4634 neonates (2445 males and 2189 females) aged...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Rodríguez G,Samper MP,Ventura P,Moreno LA,Olivares JL,Pérez-González JM

    更新日期:2004-08-01 00:00:00

  • Accuracy of blood volume estimations in critically ill children using 125I-labelled albumin and 51Cr-labelled red cells.

    abstract::Blood volume was estimated using 51chromium labelled red cells and 125iodinated human serum albumin in 5 children with sepsis, in 6 burned children and 7 children with acute lymphoblastic leukaemia. Studies of the equilibration pattern demonstrated that the mixing time of labelled red cells was prolonged to 40 minutes...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Linderkamp O,Holthausen H,Seifert J,Butenandt I,Riegel KP

    更新日期:1977-06-01 00:00:00

  • Chromosome deletion and multiple cartilaginous exostoses.

    abstract::We report a 13 year-old girl with manifestations strikingly reminiscent of the tricho-rhino-phalangeal (TRP) II or Langer-Giedion syndrome. A terminal deletion of 8q must be assumed to be the cause of her condition till proven otherwise. A similar chromosome abnormality should be searched for (blindly) in other cases ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Bühler EM,Bühler UK,Stalder GR,Jani L,Jurik LP

    更新日期:1980-03-01 00:00:00

  • Obstructive endocarditis in an immunodeficient infant.

    abstract::We report the case of 5-week-old male infant who presented as a 'near miss cot death'. He had the immunodeficient syndrome of defective neutrophil mobility and delayed umbilical cord separation. He was shown to have staphylococcal endocarditis with a large vegetation on the mitral valve, and acute obstruction of the m...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Walters MD,Deanfield JE,Robinson PJ,Matthew DJ

    更新日期:1986-12-01 00:00:00

  • Comparison of pre- and intrapartum screening of group B streptococci and adherence to screening guidelines: a cohort study.

    abstract:UNLABELLED:Implementation of guidelines for group B streptococcal (GBS) prepartum screening (PS) rarely has been prospectively evaluated. To assess PS at 35-37 weeks of gestation and compare its predictive value to that of an intrapartum screening (IS) within 7 days of delivery, a surveillance cohort study was conducte...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Kunze M,Zumstein K,Markfeld-Erol F,Elling R,Lander F,Prömpeler H,Berner R,Hufnagel M

    更新日期:2015-06-01 00:00:00

  • Clinical spectrum of steroid sulfatase deficiency: X-linked recessive ichthyosis, birth complications and cryptorchidism.

    abstract::When boys affected with steroid sulfatase deficiency are delivered, the lack of the enzyme in the placenta may cause birth complications. In postnatal life this gene defect gives rise to X-linked recessive ichthyosis. In a series of 25 patients birth complications were reported in 9 cases. Of these boys, 4 displayed b...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Traupe H,Happle R

    更新日期:1983-03-01 00:00:00

  • Long-chain polyunsaturated fatty acid status and early growth of low birth weight infants.

    abstract:UNLABELLED:We correlated arachidonic acid (AA) and docosahexaenoic acid (DHA) status with anthropometric measures and growth rates in a group of low birth weight infants (< or = 2500 g; gestational ages 30-41 weeks; n = 143). AA and DHA status were measured in erythrocytes (RBC) and plasma cholesterol esters (CE) durin...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Woltil HA,van Beusekom CM,Schaafsma A,Muskiet FA,Okken A

    更新日期:1998-02-01 00:00:00

  • Beyond pancreatic insufficiency and liver disease in cystic fibrosis.

    abstract:UNLABELLED:Cystic fibrosis is a life shortening hereditary disease, primarily leading to progressive pulmonary infection and exocrine pancreatic dysfunction. Several gastrointestinal complications other than malabsorption can arise during the disease course and with the progressively increasing life span of patients wi...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审


    authors: Demeyer S,De Boeck K,Witters P,Cosaert K

    更新日期:2016-07-01 00:00:00

  • Severe pulmonary arterial hypertension in type 1 glycogen storage disease.

    abstract::Pulmonary arterial hypertension is characterised by the presence of pulmonary hypertension (mean pulmonary artery pressure >25 mmHg at rest or >30 mmHg during exercise ) and normal pulmonary wedge pressure (<12 mmHg). Several risk factors for pulmonary arterial hypertension have been described. In the absence of any f...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Humbert M,Labrune P,Simonneau G

    更新日期:2002-10-01 00:00:00

  • Retraction Note: Adenosine triphosphate treatment for supraventricular tachycardia in infants.

    abstract::Retraction Note to: Eur J Pediatr (1994) 153:668-671 DOI 10.1007/BF02190689. This article, "Adenosine triphosphate treatment for supraventricular tachycardia in infants", published in the European Journal of Pediatrics (1994) 153/9: 668-671, Springer-Verlag 1994, has been retracted at the request of the Publisher as i...

    journal_title:European journal of pediatrics

    pub_type: 撤回出版物



    更新日期:2015-11-01 00:00:00

  • Parameters affecting length of stay in a pediatric emergency department: a retrospective observational study.

    abstract::Prolonged emergency department (ED) length of stay (LOS) is used as a proxy for ED overcrowding and is associated with adverse outcomes of patients requiring therapy and reduced patient satisfaction. Our aim was to identify and quantify variables which affect ED-LOS. Patients admitted to the pediatric ED of a large re...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Hofer KD,Saurenmann RK

    更新日期:2017-05-01 00:00:00

  • Hyponatraemia and cerebral convulsion due to short term DDAVP therapy for control of enuresis nocturna.

    abstract:UNLABELLED:Desmopressin (DDAVP) is frequently used in the treatment of primary isolated enuresis nocturna if other approaches have failed. We report a further case of hyponatraemia and cerebral convulsion due to water intoxication after intranasal DDAVP application by a 6 year-old boy with enuresis. CONCLUSION:Althoug...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Schwab M,Wenzel D,Ruder H

    更新日期:1996-01-01 00:00:00

  • Asymmetry in children with cerebral palsy and oral structure.

    abstract::Twenty-six children with cerebral palsy were examined with respect to structural asymmetry of the mouth. In 19 children there were clear cut correlations between symmetry/asymmetry of voluntary function and the oral findings. Patients with symmetrical patterns of movements had symmetrical dentition, while in those wit...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Haberfellner H,Richter M

    更新日期:1980-12-01 00:00:00

  • Central precocious puberty and growth hormone deficiency in a boy with Prader-Willi syndrome.

    abstract::In Prader-Willi syndrome (PWS) hypothalamic dysfunction is the cause of hormonal disturbances, such as growth hormone deficiency (GHD), hypogonadism, and delayed or incomplete puberty. Only a few cases of central precocious puberty (CPP) have been reported. We describe an 8.8-year-old PWS boy, with microdeletion of ch...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Crinò A,Di Giorgio G,Schiaffini R,Fierabracci A,Spera S,Maggioni A,Gattinara GC

    更新日期:2008-12-01 00:00:00

  • Sudden onset unexplained encephalopathy in infants: think of cannabis intoxication.

    abstract:UNLABELLED:The use of cannabis as both a therapeutic agent and recreational drug is common, and its availability is increasing as a result of legalization in many countries. Among older children, the manifestations of cannabis intoxication are numerous and include both neurological and systemic manifestations that are ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Lavi E,Rekhtman D,Berkun Y,Wexler I

    更新日期:2016-03-01 00:00:00

  • Genetic counselling on brittle grounds: recurring osteogenesis imperfecta due to parental mosaicism for a dominant mutation.

    abstract:UNLABELLED:Osteogenesis imperfecta (OI), a dominantly inherited connective tissue disorder, is usually caused by defects in collagen I. There is growing evidence for parental mosaicism that results in affected children born to unaffected parents. This situation poses a difficult task for the geneticist because a mosaic...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Raghunath M,Mackay K,Dalgleish R,Steinmann B

    更新日期:1995-02-01 00:00:00

  • 3-Methylglutaconic and 3-methylglutaric aciduria in a patient with suspected 3-methylglutaconyl-CoA hydratase deficiency.

    abstract::A girl suffering from marked muscular hypotonia, severe statomotor and mental retardation, bilateral optic atrophy with chorioretinal degeneration, convulsions and a moderate compensated metabolic acidosis is described. Screening for metabolic disorders revealed massive 3-methylglutaconic with 3-methylglutaric aciduri...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Lehnert W,Scharf J,Wendel U

    更新日期:1985-03-01 00:00:00

  • Inpatient treatment of obese children: a multicomponent programme without stringent calorie restriction.

    abstract:UNLABELLED:This prospective clinical case-control study describes the effect of an inpatient multicomponent treatment programme for obese children and adolescents on their weight and psychological well being. We studied 38 patients and 38 controls on the waiting list, matched for age and gender, referred because of obe...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Braet C,Tanghe A,Bode PD,Franckx H,Winckel MV

    更新日期:2003-06-01 00:00:00

  • Periventricular leucomalacia: a review.

    abstract:UNLABELLED:Periventricular leucomalacia is a condition that causes lifelong disability and considerable economic burden. It occurs in premature infants of less than 32 weeks gestation due to their unique anatomical features. The white matter of these infants is poorly vascularised and contains oligodendrocyte progenito...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审


    authors: Blumenthal I

    更新日期:2004-08-01 00:00:00

  • Adolescents' drug use and drug knowledge.

    abstract:UNLABELLED:Self-medication is a common event. To use drugs correctly, a basic knowledge about drugs is required. Poor data are available about adults' drug knowledge. Furthermore, adolescents' basic drug knowledge has not been investigated. This study was designed in order to explore adolescents' drug use and knowledge...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Stoelben S,Krappweis J,Rössler G,Kirch W

    更新日期:2000-08-01 00:00:00

  • Inconsistencies in the management of neonates born to mothers with "thyroid diseases".

    abstract::Although thyroid medications are frequently prescribed during pregnancy, paediatricians treating the respective neonates often have no information about the underlying maternal thyroid disease, and inconsistencies in postnatal diagnostics may result. We analysed a cohort of 1819 mothers admitted for delivery in 1 year...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Weissenfels PC,Woelfle J,Korsch E,Joergens M,Gohlke B

    更新日期:2018-11-01 00:00:00

  • Evolution of the proportion of patients with Down's syndrome karyotyped in Belgium since 1960.

    abstract::Estimation of the total number of infants with DS born each year in Belgium allows evaluation of changes in the proportion of children with DS in whom a karyotype has been established. This proportion steadily increased to 95% of the children with DS born in 1978. ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Evers-Kiebooms G,Vlietinck R,van den Berghe H

    更新日期:1985-03-01 00:00:00

  • Clinical characteristics of children with hypoparathyroidism due to 22q11.2 microdeletion.

    abstract:UNLABELLED:The phenotypes of chromosomal 22q11.2 microdeletion are quite variable among individuals and hypoparathyroidism (HP) constitutes a definite portion of the clinical spectrum. For the correct diagnosis and pertinent follow up of the HP children due to del22q11.2, we tried to delineate the clinical characterist...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Adachi M,Tachibana K,Masuno M,Makita Y,Maesaka H,Okada T,Hizukuri K,Imaizumi K,Kuroki Y,Kurahashi H,Suwa S

    更新日期:1998-01-01 00:00:00

  • Metabolic acidosis in the first 14 days of life in infants of gestation less than 26 weeks.

    abstract:UNLABELLED:Extremely immature newborns develop a self-limiting normal anion gap metabolic acidosis in early life. This study examined the natural history of this acidosis in a population of infants of gestation less than 26 weeks in the first 14 days of life. The acidosis was maximal on day 4 with a mean base deficit o...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Bourchier D,Weston PJ

    更新日期:2015-01-01 00:00:00

  • Total parenteral nutrition associated cholestasis: a predisposing factor for sepsis in surgical neonates?

    abstract::Of 496 neonates and infants less than 1 year of age admitted to the paediatric surgical intensive care unit (PSICU) over a 5 year period (1983-1987), 94 required total parenteral nutrition (TPN) for more than 14 consecutive days, generally due to congenital anomalies of the digestive tract. Cholestasis occurred in 15 ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Bos AP,Tibboel D,Hazebroek FW,Bergmeijer JH,van Kalsbeek EJ,Molenaar JC

    更新日期:1990-02-01 00:00:00

  • Zinc deficiency in an exclusively breast-fed preterm infant.

    abstract:UNLABELLED:A formerly premature, exclusively breast-fed infant with severe zinc deficiency syndrome is presented. He showed the characteristic erosive skin changes, including alopecia, as seen in acrodermatitis enteropathica. In addition, he manifested a failure to thrive and irritability. The diagnosis was confirmed b...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Heinen F,Matern D,Pringsheim W,Leititis JU,Brandis M

    更新日期:1995-01-01 00:00:00

  • Limp as unusual presentation of Langerhans' cell histiocytosis.

    abstract:UNLABELLED:An isolated eosinophilic granuloma involving the posterior elements of a lumbar vertebra is reported in a 3-year-old boy presenting with progressive limp. Radiological investigations revealed osteolysis of the L5 right pedicle. MRI showed a well-defined homogeneous mass with nonspecific signal intensity. An ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Bodart E,Nisolle JF,Maton P,Delos M,Trigaux JP,Gilliard C,Tuerlinckx D,Ninane J

    更新日期:1999-05-01 00:00:00

  • A 4-month-old boy with acrodermatitis enteropathica-like symptoms.

    abstract::A 4-month-old boy was admitted for having diffuse eruption in the perianal region, legs, trunk hands, and face with failure to thrive, edema, hypoalbuminemia, and anemia. The patient was thought to have acrodermatitis enteropathica-like eruption due to malabsorption. The eruption completely resolved with enzyme supple...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Pekcan S,Kose M,Dogru D,Sekerel B,Atakan N,Ozcelik U,Cobanoglu N,Yalcin E,Kiper N

    更新日期:2009-01-01 00:00:00

  • Fetomaternal haemorrhage and prenatal intracranial bleeding: two more causes of blueberry muffin baby.

    abstract:UNLABELLED:Blueberry muffin lesions are associated with prenatal infections, severe and chronic anemia and neoplastic infiltrative diseases. In the first two instances they represent postnatal re-expression of cutaneous haematopoiesis, in the latter they are cutaneous localizations of a neoplastic disease. Chronic pren...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Smets K,Van Aken S

    更新日期:1998-11-01 00:00:00

  • Nutrition studies in treated infants and children with phenylketonuria: vitamins, minerals, trace elements.

    abstract::Chemically defined or elemental medical foods provide the majority of protein equivalent in the diets of children treated for phenylketonuria (PKU). Because of the restricted intake of high biologic value protein, children with PKU often have lower than normal plasma concentrations of ferritin and zinc. Few reported s...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Acosta PB

    更新日期:1996-07-01 00:00:00