当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PEDIATRICS期刊下所有文献 > Late-onset sepsis due to urinary tract infection in very preterm neonates is not uncommon.

Late-onset sepsis due to urinary tract infection in very preterm neonates is not uncommon.

Abstract：

:Urinary tract infection (UTI) is a common cause of sepsis in infants. Premature infants hospitalized at a neonatal intensive care unit often have risk factors for infection. In this group, the risk of UTI is not clearly known, and guidelines for urine analysis are not unanimous. We aimed to identify the risk of UTI in premature infants with central lines, suspected of late-onset sepsis. We analyzed all 1402 infants admitted to our hospital between 2006 and 2014 with a gestational age less than 32 weeks. Six hundred sixty-two episodes of sepsis evaluations were found with an unknown source of infection based on clinical symptoms. In half of this group, urine analysis was performed identifying UTI in 11.3% (24/212). In 13 of these infants (54%) with a UTI, infection was due to Candida albicans. In at least four episodes, the diagnosis and treatment would have been delayed if urine analysis had not been performed. CONCLUSION:Based on these findings, we conclude that in premature infants with central lines, urine analysis should be performed routinely when signs of infection occur beyond 72 h after birth. Urine collection should not be delayed and cultures should preferably be performed before the start of the antibiotic treatment. What is known: • In preterm infants, the presence of other risk factors for infection might make clinicians reluctant to obtain urine cultures during sepsis evaluation. • An internal survey demonstrated that there is no consensus within the NICUs in The Netherlands regarding urine analysis as part of LOS work-up. What is new: • The risk of UTI in the NICU population (11.3%) is comparable to term infants; therefore, urine analysis should be performed routinely when LOS is suspected. • Candida albicans was the most frequently (54%) detected pathogen causing UTI in this population.

journal_name

Eur J Pediatr

journal_title

European journal of pediatrics

authors

Mohseny AB,van Velze V,Steggerda SJ,Smits-Wintjens VEHJ,Bekker V,Lopriore E

doi

10.1007/s00431-017-3030-9

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

33-38

issue

eissn

0340-6199

issn

1432-1076

pii

10.1007/s00431-017-3030-9

journal_volume

177

pub_type

杂志文章

在线工具

Late-onset sepsis due to urinary tract infection in very preterm neonates is not uncommon.