Total parenteral nutrition associated cholestasis: a predisposing factor for sepsis in surgical neonates?

Abstract:

:Of 496 neonates and infants less than 1 year of age admitted to the paediatric surgical intensive care unit (PSICU) over a 5 year period (1983-1987), 94 required total parenteral nutrition (TPN) for more than 14 consecutive days, generally due to congenital anomalies of the digestive tract. Cholestasis occurred in 15 of them and 12 of these patients developed sepsis. In contrast, of the 79 patients on TPN that remained free from cholestasis, only 23 developed sepsis. The mortality rate for the TPNAC-group was substantially higher than for the group without TPNAC. It is suggested that development of TPNAC might lead to impairment of non-specific cellular immunity in neonates.

journal_name

Eur J Pediatr

authors

Bos AP,Tibboel D,Hazebroek FW,Bergmeijer JH,van Kalsbeek EJ,Molenaar JC

doi

10.1007/BF02171565

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

351-3

issue

5

eissn

0340-6199

issn

1432-1076

journal_volume

149

pub_type

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