Abstract：
:Pediatric palliative care (PPC) focuses on children and adolescents with life-limiting diseases. It may be initiated at various points of the disease trajectory, if possible early enough to support living with the best possible quality of life despite a limited lifespan. From birth to adolescence, children with a broad spectrum of diseases may benefit from PPC. Since 50% of deaths in childhood occur within the first year of life, PPC is just as relevant to neonatology. Causes of death in the neonate and young infant are due to perinatal conditions such as preterm birth and congenital disorders and syndromes; in older children, external causes, such as traumatic injuries, outweigh disease-related causes of death. PPC may last from a few hours or days for neonates to many years for children with complex chronic conditions. For neonates, PPC often has the character of end-of-life (EOL) care followed by bereavement care for the family. For older children, PPC can clearly be differentiated from EOL care; its indications include progress or deterioration of disease, marked instability of the child's condition, increase in the need for technical or medical support, increase in suffering, or failure of treatment. If a child's need for palliative care is established, useless and potentially harmful treatments may be withheld and informed choices can be made about treatment, care, and the remaining life of the child. Conclusion This review aims to provide knowledge for clinicians who care for children and adolescents at risk of dying from their disease. PPC can improve the child's remaining lifetime by focusing on quality of life and goals that are defined by the child and his or her family.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Bergstraesser Edoi
10.1007/s00431-012-1710-zsubject
Has Abstractpub_date
2013-02-01 00:00:00pages
139-50issue
2eissn
0340-6199issn
1432-1076journal_volume
172pub_type
杂志文章,评审abstract：UNLABELLED:Human parechoviruses (HPeV) have been recently recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence in infants <1 month in Spain and, secondly, to analyse the clinical and epidemiological characteristics of the infected patien...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/s00431-015-2566-9
更新日期：2015-11-01 00:00:00
abstract：UNLABELLED:To study the developmental effects of prenatal exposure to opiates, a prospective follow up study of 34 drug-exposed (opiates and nicotine) and 42 reference infants (nicotine exposure only) was conducted from January 1992 to September 1995. At the time of delivery, 12 of 34 mothers used opiates without medic...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050923
更新日期：1998-09-01 00:00:00
abstract：UNLABELLED:Blueberry muffin lesions are associated with prenatal infections, severe and chronic anemia and neoplastic infiltrative diseases. In the first two instances they represent postnatal re-expression of cutaneous haematopoiesis, in the latter they are cutaneous localizations of a neoplastic disease. Chronic pren...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050970
更新日期：1998-11-01 00:00:00
abstract：:The board game Kaledo was proven to be effective in improving nutrition knowledge and in modifying dietary behavior in students attending middle and high school. The present pilot study aims to reproduce these results in younger students (7-11 years old) attending primary school. A total of 1313 children from ten scho...
journal_title：European journal of pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00431-018-3091-4
更新日期：2018-09-01 00:00:00
abstract：:The present study was done to evaluate the effect of short-term dietary therapy on 148 dyslipidaemic children (24 familial hypercholesterolaemia, 105 non-familial hypercholesterolaemia and 19 hypertriglyceridaemia), detected by mass screening in children at 18 months of age. In the model diet used for treatment, 15% o...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01957537
更新日期：1993-11-01 00:00:00
abstract：UNLABELLED:Patients with glycogen storage disease type 1b (GSD1b) not only show hepatomegaly, hypoglycaemia and lactic acidosis, but also neutropenia and neutrophil dysfunction. Here, we report improvement of neutropenia and neutrophil function in a 22-year-old male GSD1b patient who had undergone living-related partia...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-004-1405-1
更新日期：2004-04-01 00:00:00
abstract：:Antithyroid drugs, considered the treatment of choice for hyperthyroidism during pregnancy, may have an adverse effect on intellectual development of the offspring. We examined the intellectual capacity of 31 subjects aged 4-23 years, born to women with Graves disease who received antithyroid drugs throughout pregnanc...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01957719
更新日期：1992-08-01 00:00:00
abstract：:Most drugs that are currently prescribed in pediatrics have not been tested in children. Pediatric drug studies are stimulated in the USA by the pediatric exclusivity provision under the Food and Drug Administration Modernization Act (FDAMA) that grants patent extensions when pediatric labeling is provided. We investi...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-006-0381-z
更新日期：2007-08-01 00:00:00
abstract：:We evaluated, both in toilet-trained and not-toilet-trained children, the impact of cleaning the genital area with plain water on the false positive rate at urine dipstick, and evaluated which factors could be associated to falsely positive findings. We prospectively enrolled 612 patients consecutively attending our n...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-018-3215-x
更新日期：2018-10-01 00:00:00
abstract：:The involvement of minors in clinical research is inevitable to catch up with the lack of drugs labeled for pediatric use. To encourage the responsible conduct of pediatric clinical trials in the EU, an extensive legal framework has been developed over the past decade in which the practical, ethical, legal, social, an...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-008-0915-7
更新日期：2009-10-01 00:00:00
abstract：:Infiltration of the stomach wall by air, first described by Fraenkel in 1889 [3], is a very rare condition. We describe the first reported case of gastric pneumatosis occurring in a child with complex congenital heart disease after cardiac surgery. ...
journal_title：European journal of pediatrics
pub_type： 信件
doi：10.1007/s004310051338
更新日期：2000-07-01 00:00:00
abstract：UNLABELLED:Both news media and entertainment fiction may lead to short-term and enduring fright reactions. Even TV programs, movies and news made for children may trigger fear. Preoperational children (3 to 7 years of age) are most afraid of fantasy characters, transformations and interpersonal violence. Operational ch...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-011-1632-1
更新日期：2012-04-01 00:00:00
abstract：:Two newborns with congenital rubella syndrome are reported. Cranial sonography demonstrated bilateral cystic lesions in the subependymal germinal matrix. Congenital rubella and cytomegalovirus (CMV) infections are the most common proven causes of subependymal cysts of nonhaemorrhagic origin in the newborn. The sonogra...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441403
更新日期：1988-12-01 00:00:00
abstract：:Chronic lung disease of prematurity (CLD) is a common respiratory disorder of preterm infants. At autopsy, fibroblast proliferation, and components of the extracellular matrix, including collagen and fibronectin, are markedly increased in the lungs of infants who die from CLD. Examination of broncho-alveolar fluid sug...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF01958074
更新日期：1996-08-01 00:00:00
abstract：:In order to determine the hepatotoxicity of rifampicin in children treated for tuberculosis, a survey was performed of 18 children receiving this medicine in combination with isoniazid. Fifteen of the 18 children (83%) showed a rise in ASAT values and 11 (61%) in ALAT values exceeding 29U/L. Seven children with maxima...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441477
更新日期：1980-09-01 00:00:00
abstract：:The renal function of 12 patients with non vitamin B12 responsive methylmalonic acidaemia has been investigated. Eight patients had reduced glomerular filtration rates, but the plasma creatinine concentration was only raised in those with values of less than 40 ml/min per 1.73 m2 surface area. The reduction in glomeru...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00444131
更新日期：1989-01-01 00:00:00
abstract：:Before promoting certain types of physical activities, the Health Promotion and Disease Prevention Department of Malta wanted to know whether children knew how to perform them in the first place, and if not, what barriers they had encountered. A cross-sectional, self-reported study involved 11-year-old students (boys ...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/s00431-010-1185-8
更新日期：2010-09-01 00:00:00
abstract：:Neonatal diabetes, which may be transient or permanent, is rare. Most patients are full-term but small- for-date infants. Typical symptoms of diabetes mellitus occur within the first 4 weeks of life, requiring insulin therapy and very strict blood glucose monitoring. Subsequent growth and psychomotor development are u...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF01958635
更新日期：1995-12-01 00:00:00
abstract：:The varying clinical manifestations of Lyme borreliosis, transmitted by Ixodes ricinus and caused by Borrelia burgdorferi, frequently pose diagnostic problems. Diagnostic strategies vary between early and late disease manifestations and usually include serological methods. Erythema migrans is pathognomonic and does no...
journal_title：European journal of pediatrics
pub_type： 杂志文章,实务指引
doi：10.1007/s00431-012-1779-4
更新日期：2012-11-01 00:00:00
abstract：UNLABELLED:This study assessed health-related quality of life (HRQoL) reported by overweight adolescents and compared to their parent-proxy perception of HRQoL, according to adolescent gender, adolescent age, and parent gender. Patients and a total of 179 adolescents aged 10 to 18 years with excess weight were evaluate...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-013-2050-3
更新日期：2013-10-01 00:00:00
abstract：:Early identification of infants being at high risk to become obese at their later childhood or adolescence can be of vital importance in any obesity prevention initiative. The aim of the present study was to examine the utility and applicability of the "Childhood Obesity Risk Evaluation (CORE)" index as a screening to...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-016-2799-2
更新日期：2016-12-01 00:00:00
abstract：:The topography and morphology of the lacrimal ducts in newborn infants was demonstrated by means of post mortem dacryocystograms and microphotograms of histologic slides. Because of bends in the course of the lower tear duct, a percentage of probings will fail to effect satisfactory perforation of the Hasner membrane....
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442367
更新日期：1978-09-08 00:00:00
abstract：:The first Scandinavian cases of Zellweger syndrome (ZS) are described. A brother and sister, children of first cousins, had the typical clinical symptoms and pathological findings. Extensive metabolic studies in the boy were negative. Pipecolic acid in the urine was not elevated. Both children died at 14 weeks of age....
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00493539
更新日期：1978-04-20 00:00:00
abstract：INTRODUCTION:This randomised, observer-blind clinical trial conducted in Turkey evaluated the immunogenicity, safety and interchangeability of three paediatric inactivated hepatitis A vaccines in 424 seronegative children between 1 and 15 years of age. METHODS:Potential subjects were screened for anti-hepatitis A viru...
journal_title：European journal of pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00431-007-0432-0
更新日期：2007-06-01 00:00:00
abstract：:In five L-thyroxine-substituted hypothyroid children with partial epilepsy serum total thyroxine (T4) and free T4 (FT4) significantly (P less than 0.01) decreased following 2 months of carbamazepine (CBZ) administration (20 mg/kg per BW per day) from mean (+/- SD) values of 12.7 +/- 1.1 micrograms/dl and 15.5 +/- 1.8 ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441860
更新日期：1986-04-01 00:00:00
abstract：:Prolonged emergency department (ED) length of stay (LOS) is used as a proxy for ED overcrowding and is associated with adverse outcomes of patients requiring therapy and reduced patient satisfaction. Our aim was to identify and quantify variables which affect ED-LOS. Patients admitted to the pediatric ED of a large re...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-017-2879-y
更新日期：2017-05-01 00:00:00
abstract：:Bone health is extremely important in early childhood because children with low bone mineral density (BMD) are at a greater risk of bone fractures. While physical activity and intake of both calcium and vitamin D benefit BMD in older children, there is limited research on the determinants of good bone health in early ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-019-03465-x
更新日期：2020-01-01 00:00:00
abstract：:A technetium-99m pertechnetate Meckel scan is the standard diagnostic test to diagnose Meckel diverticulum. Although a negative scan does not exclude Meckel diverticulum, it should be kept in mind that the diagnosis can be missed on the basis of a single negative scan. Another important point is the typical position o...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-009-0946-8
更新日期：2009-12-01 00:00:00
abstract：:The study was planned to determine identifiable starting points of a trend towards obesity and the influence of variables in preschool children aged 0 to 6 years. In this longitudinal follow-up study, 102 children were enrolled. Anthropometric measurements such as weight-height centiles (specific for gender and age gr...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-010-1343-z
更新日期：2011-06-01 00:00:00
abstract：:We report on a 10-year-old girl who was presented to the Emergency Department with a 3-day history of "vaginal bleeding", the cause of which was determined to be urethral prolapse. Urethral prolapse occurs when the urethra mucosa evaginates beyond the urethral meatus. This uncommon condition in prepubescent girls shou...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-007-0523-y
更新日期：2008-05-01 00:00:00
