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Evaluation of long term tobramycin therapy in patients with cystic fibrosis and advanced pulmonary disease.

Abstract：

:To nine cystic fibrosis patients with chronic bronchopulmonary infection of severely damaged lungs invaded by Pseudomonas aeruginosa, eleven courses of prolonged tobramycin treatment (5 mg/kg/day) for four to 16 weeks were administered. Pulmonary symptoms improved and a better quality of life was achieved in all but one patient. Objective parameters (chest X-ray, pulmonary function tests) changed to a lesser extent. In only one patient was Pseudomonas eradicated from the sputum but reappeared after discontinuation of therapy. In the rest of the patients Pseudomonas was significantly suppressed or replaced by other pathogens. Four patients showed rises of antibody titres to Candida and two to Aspergillus fumigatus. No nephrotoxic side effects were observed, but vestibular function was reversibly impaired in one patient without corresponding clinical symptoms. No bacterial resistance to tobramycin was observed during therapy.

journal_name

Eur J Pediatr

journal_title

European journal of pediatrics

authors

Paporisz U,Posselt HG,Wönne R,Ristow W,Röser D,Knothe H,Bender SW

doi

10.1007/BF00441362

subject

Has Abstract

pub_date

1979-04-03 00:00:00

pages

259-69

issue

4

eissn

0340-6199

issn

1432-1076

journal_volume

130

pub_type

杂志文章

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