Recombinant human interferon-gamma in patients with chronic granulomatous disease--European follow up study.

Abstract:

:This was an uncontrolled, open-label follow up study of a previous 12-month, randomized, double-blind, placebo-controlled trial performed to assess the long-term efficacy and safety of Recombinant Human Interferon Gamma (rIFN-gamma) in patients with chronic granulomatous disease (CGD). In two centres, 28 patients (24 male, 4 female) with a mean age of 16 years (range 3-37) entered the open-label phase. The patients were treated for a mean of 880 days (range 97-1375 days). Visits were scheduled every 180 days and patients completed one to six visits. rIFN-gamma was administered subcutaneously three times weekly at a dose of 0.05 mg per m2. During the open-label phase of the study 12 patients experienced a serious infection requiring hospitalization within 880 days. The median infection-free time was 993 days. No obvious increase of infections over time was seen. Phagocyte superoxide anion production and phagocyte staphylococcal killing were not influenced by therapy. Seven patients were withdrawn from the study, one because of an adverse reaction, three on their own wish and the other three because they changed to another trial. No patient died during the study. Conclusion. Treatment of patients with CGD with intracellular active antibiotics and additional interferon gamma as infection prophylaxis is safe and justified.

journal_name

Eur J Pediatr

authors

Weening RS,Leitz GJ,Seger RA

doi

10.1007/BF01957365

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

295-8

issue

4

eissn

0340-6199

issn

1432-1076

journal_volume

154

pub_type

临床试验,杂志文章,随机对照试验
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    doi:10.1007/BF01972977

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    更新日期:1995-01-01 00:00:00

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    authors: Linna O,Uhari M

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  • Control of proven pulmonary and suspected CNS aspergillus infection with itraconazole in a patient with chronic granulomatous disease.

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    authors: Aycicek A,Varma M,Ahmet K,Abdurrahim K,Erel O

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  • Toxic shock syndrome and streptococcal myositis: three case reports.

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    pub_type: 杂志文章

    doi:10.1007/BF00497680

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    更新日期:1976-08-16 00:00:00

  • New insights into lipid and fatty acid metabolism via stable isotopes.

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    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/pl00014276

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    journal_title:European journal of pediatrics

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    doi:10.1007/BF00442403

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    更新日期:1980-06-01 00:00:00

  • Mitral valve prolapse in Turner syndrome.

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    pub_type: 杂志文章

    doi:10.1007/BF00441551

    authors: Bastianon V,Pasquino AM,Giglioni E,Bosco G,Tebaldi L,Cives C,Colloridi V

    更新日期:1989-04-01 00:00:00

  • Enteral feeding in infants

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    journal_title:European journal of pediatrics

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    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF00443258

    authors: Sagi E,Eyal F,Armon Y,Arad I,Robinson M

    更新日期:1981-11-01 00:00:00

  • A case of perineal hypospadias with paracentric inversion of chromosome 14.

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    更新日期:1986-02-01 00:00:00

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  • Mild closed head injury in children compared to traumatic fractured bone; neurobehavioural sequelae in daily life 2 years after the accident.

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    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s004310051061

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    更新日期:1999-03-01 00:00:00

  • Rett syndrome in a patient with medium chain acyl-CoA dehydrogenase deficiency.

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    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF01954516

    authors: Beekman RP,Hofstee N,Smeitink JA,Poll-The BT,Duran M

    更新日期:1994-04-01 00:00:00

  • Syphilis returns to the suburbs.

    abstract::Congenital syphilis is now rare in Australia, particularly in suburban areas. The disease is both preventable and treatable, however, missed or late diagnosis can lead to catastrophic effects. We report an infant who developed congenital syphilis after multiple opportunities for preventing this condition were missed. ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s00431-005-0050-7

    authors: Hargrove A,Curtis N

    更新日期:2006-05-01 00:00:00

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    pub_type: 杂志文章

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    authors: Miyazono A,Abe J,Ogura M,Sato M,Fujimaru T,Kamei K,Ito S

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  • Long term renal prognosis of Henoch-Schönlein purpura in an unselected childhood population.

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    journal_title:European journal of pediatrics

    pub_type: 杂志文章

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    更新日期:1988-02-01 00:00:00

  • Multiple oxidative phosphorylation deficiencies in severe childhood multi-system disorders due to polymerase gamma (POLG1) mutations.

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    pub_type: 杂志文章

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  • Laryngoscope burn risk in neonatal intubation.

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    更新日期:1989-12-01 00:00:00

  • Outcomes following venoarterial extracorporeal membrane oxygenation in children with refractory cardiogenic disease.

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    journal_title:European journal of pediatrics

    pub_type: 杂志文章

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    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审

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  • Increasing the dose of oral vitamin K prophylaxis and its effect on bleeding risk.

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    journal_title:European journal of pediatrics

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